Abstract Background The severity of endoscopic gastric atrophy ( EGA ), high‐stage O perative L ink on G astritis A ssessment OLGA ) gastritis (i.e., stage III or IV and extensive intestinal metaplasia IM with incomplete subtype have been separately reported as high‐risk factors cancer (GC). aim this study was to evaluate the associations between these pathologic characteristics. Materials methods cross‐sectional conducted 280 patients functional dyspepsia at U niversity M edical C enter H o...

The grade of gastric mucosa atrophy caused by Helicobacter pylori (H. pylori) infection is closely associated with the risk cancer, especially intestinal type. Interobserver and intraobserver agreement for endoscopic in subjects H. pylori-uninfected, currently infected past was investigated.Endoscopic images 91 patients, 34 per patient, were assessed. assessors 4 endoscopist groups: Japanese Vietnamese experienced (≥7, ≤ 15 year experience endoscopy) beginner (≤ 3 experience) groups. Each...

Because of self-renewal, strong proliferation in vitro, abundant sources for isolation, and a high differentiation capacity, mesenchymal stem cells are suggested to be potentially therapeutic liver fibrosis/cirrhosis. In this study, we evaluated the treatment effects mouse bone marrow-derived (BM-MSCs) on cirrhosis induced by carbon tetrachloride. Portal tail vein transplantations were examined evaluate different injection routes model at 21 days after transplantation. BM-MSCs...

The aims of the present study were to evaluate role moderate-to-severe endoscopic gastric atrophy (EGA) on predicting Operative Link Gastritis Assessment (OLGA) gastritis stage, and assess association high-stage OLGA with neoplasia in patients non-ulcer dyspepsia.A cross-sectional was carried out 280 dyspeptic outpatients. EGA assessed according Kimura-Takemoto classification. stage established staging system Vienna pathologists who read specimens kept blind results.The mean age 46.1 years...

Background/Aims: Stratification for gastric cancer risk typically involves histologic grading of biopsies. This study aimed to compare endoscopic assessment atrophy and mapping stratification in a region with relatively high cancer.Methods: Endoscopic were compared Vietnamese patients functional dyspepsia. was graded according the Kimura-Takemoto classification. High-risk lesions defined as dysplasia, Operative Link on Gastritis Assessment (OLGA) gastritis stage III/IV, intestinal metaplasia...

Hepatic stellate cells (HSCs) activation, a critical event in liver fibrosis, has been recently shown to be related autophagy. Determine whether chloroquine (CQ) could affect (i) the activation of HSC vivo and (ii) hepatic damage mice acute injury model.The was induced BALB/c by carbon tetrachloride (CCl4 group); 24 h before after CCl4 administration animals were treated CQ + group). As control, olive oil considered. After 48 from /olive administration, blood samples, tissues, HSCs harvested...

Abstract Background and Aim The risk factors associated with the increase in prevalence of gastroesophageal reflux disease (GERD) are not consistent across countries there have been few studies Asia past 10 years. This study was conducted to assess features GERD Vietnamese patients. Methods A cross‐sectional on 1947 out‐patients ≥18 years age who were presented upper gastrointestinal symptoms underwent esophagogastroduodenoscopy. Reflux esophagitis graded according Los Angeles...

Background/Aims: Accurate neoplastic prediction can significantly decrease costs associated with pathology and unnecessary colorectal polypectomies. Narrow band imaging (NBI) dual-focus (DF) mode are promising emerging optical technologies for recognizing features of polyps digitally. This study aimed to clarify the clinical usefulness NBI without DF assistance in small (<10 mm).Methods: cross-sectional included 530 from 343 consecutive patients who underwent colonoscopy at University...

Sessile serrated lesions (SSLs) are considered precancerous colorectal that should be detected and removed to prevent cancer. Previous studies in Vietnam mainly investigated the adenoma pathway, with limited data on pathway.

Abstract The current barrier for investigation of Barrett esophagus (BE) in Asia is diagnostic standardization, which a challenge to identify its true risk factors. This study aimed investigate the prevalence, clinical characteristics and factors BE Vietnamese patients with upper gastrointestinal symptoms. A cross-sectional was conducted on consecutive outpatients who underwent endoscopy. Endoscopically suspected esophageal metaplasia (ESEM) clearly visible at least 1 cm above...

The incidence of early-onset (under 50 years age) colorectal cancer (CRC) in the Vietnamese has been reported to be quite higher than that Japanese. To clarify differences genetic alterations between and Japanese CRCs, we investigated mutations K-ras mitochondrial DNA (mtDNA) high-frequency microsatellite instability (MSI-H) CRCs patients. We enrolled 60 233 patients with invasive CRCs. was extracted from formalin-fixed, paraffin-embedded tissue sections. were examined PCR-single-strand...

Background: The application of mesenchymal stem cell (MSC) therapy in liver fibrosis treatment has been increasingly investigated recent years. MSCs obtained from a variety sources (e.g. bone marrow, umbilical cord blood and adipose tissue) have studied achieved remarkable results. In this study, we compared the effects adipose-derived cells (AD-MSC) transplantation with marrow-derived (BM-MSC) mouse model fibrosis, induced by carbon tetrachloride (CCl4).
 Methods: Eight-week old mice...

Chromoendoscopy and narrow-band imaging (NBI) have been reported to aid in the diagnosis of gastric intestinal metaplasia (GIM). This study aimed assess diagnostic validity chromoendoscopy combined with NBI GIM Vietnamese.A cross-sectional was carried out on patients dyspeptic symptoms who underwent esophagogastroduodenoscopy (EGD) at University Medical Center Ho Chi Minh City. We compared detection rates group examined white-light endoscopy (WLE) alone those WLE combination NBI.A total 374...

Abstract To investigate the time‐trend and endoscopic‐pathological characteristics of early‐onset gastric carcinoma (EOGC) in Vietnamese patients. All patients who underwent upper gastrointestinal endoscopy at a tertiary hospital during 2014–2019 period had pathologically confirmed were retrospectively recruited. The demographic data endoscopic pathological findings from all recorded analyzed to compare EOGC group (i.e., ≤40 years age) with older (>40 age). Out 1668 carcinoma, 151 (9.1%)...

Background . Current guidelines recommend that extensive gastric intestinal metaplasia (GIM) be considered as a high-risk marker for the development of cancer (GC). But there is emerging evidence incomplete GIM subtype also marker. Aims To evaluate performance biopsy sites according to updated Sydney system on detecting and assess its association with extension. Patients methods A cross-sectional study was conducted 280 Vietnamese patients nonulcer dyspepsia. Biopsy specimens were taken from...

<b><i>Introduction:</i></b> Severe and extensive gastric atrophy, or incomplete intestinal metaplasia, dysplasia are considered high-risk precancerous lesions (HGPLs). Endoscopic findings based on the endoscopic Kyoto classification (EKC) Kimura-Takemoto (KTC) have been reported to be significantly associated with HGPLs. This study aimed compare these two classifications in predicting active <i>Helicobacter pylori</i> (<i>H. pylori</i>)...

Background and objectives Achieving accurate real-time optical diagnoses of colorectal polyps with high-confidence predictions is crucial for appropriate decision-making in daily practice. The dual-focus (DF) magnification mode helps endoscopists scrutinize subtle features polyp surfaces vessel patterns. This prospective study aimed to evaluate the impact DF imaging on enhancing rate narrow-band (NBI)-based diagnosis. Methods Consecutive adult patients who underwent colonoscopy had small...

Abstract Background and Aim Small rectosigmoid colorectal polyps (<10 mm) are prevalent, with a low prevalence of advanced neoplastic lesions. The “diagnose‐and‐leave” strategy, employing narrow band imaging (NBI), is gaining popularity for its safety cost‐effectiveness by reducing polypectomy complications minimizing histopathology expenses. This study assessed the diagnostic efficacy NBI dual focus (DF) magnification real‐time prediction explored feasibility implementing this strategy...

Abstract Background/Aims Sessile‐serrated lesions (SSLs) are challenging to detect due their typically subtle appearance. The Workgroup serrAted polypS and Polyposis (WASP) classification was developed diagnose SSLs endoscopically. This study aimed evaluate the endoscopic characteristics of performance WASP in Vietnamese population. Methods cross‐sectional carried out on patients with lower gastrointestinal symptoms who underwent colonoscopy at a tertiary hospital. Univariate multivariate...

The JNET classification, combined with magnified narrowband imaging (NBI), is essential for predicting the histology of colorectal polyps and guiding personalized treatment strategies. Despite its recognized utility, diagnostic efficacy classification using NBI dual focus (DF) magnification requires exploration in Vietnamese context. This study aimed to investigate performance NBI-DF mode Vietnam. A cross-sectional was conducted at University Medical Center Ho Chi Minh City, During real-time...

Introduction: To date, there have been many studies indicating the positive effects of stem cells on treating liver cirrhosis. In this study, we used umbilical cord blood-derived mesenchymal (UCB-MSCs) for treatment in a mouse model Specifically, determined and compared effectiveness two methods MSC injection (tail vein versus portal vein).
 Methods: Liver cirrhosis male Swiss mice (of age approximately 11 weeks or under) was induced by administration carbon tetrachloride (CCl4; 1...