A5072874640- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Congenital Heart Disease Studies
- Adrenal and Paraganglionic Tumors
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Lymphoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Pregnancy and preeclampsia studies
- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Pancreatic and Hepatic Oncology Research
- Chromatin Remodeling and Cancer
Children's Hospital of Orange County
2018-2025
Ball State University
2022
Fielding Graduate University
2022
University of California, Irvine
2020-2022
University of Wisconsin–Madison
2022
Children's Hospital of Los Angeles
2015-2018
University of Southern California
2016-2018
RELX Group (Netherlands)
2017
Children's Center
2017
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2016
Purpose Alisertib is an oral Aurora A kinase inhibitor with preclinical activity in neuroblastoma. Irinotecan and temozolomide have patients advanced The goal of this phase I study was to determine the maximum tolerated dose (MTD) alisertib irinotecan population. Patients Methods age 1 30 years relapsed or refractory neuroblastoma were eligible. received tablets at levels 45, 60, 80 mg/m 2 per day on days 7 along 50 intravenously 100 orally 5. Dose escalation followed rolling six design....
Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB risk stratification, which may aid therapeutic decision making, family counseling, and selection patient groups suitable targeted genetic analysis. Purpose To develop machine learning strategies that identify the four clinically significant molecular subgroups. Materials Methods In this retrospective study, consecutive patients with newly diagnosed at MRI 12 international sites between July 1997 May 2020...
Background Myeloablative therapy for high-risk neuroblastoma commonly includes melphalan. Increased cellular glutathione (GSH) can mediate melphalan resistance. Buthionine sulfoximine (BSO), a GSH synthesis inhibitor, enhances activity against cell lines, providing the rationale Phase 1 trial of BSO-melphalan. Procedures Patients with recurrent/resistant received BSO (3 gram/m2 bolus, then 24 grams/m2/day infusion days −4 to −2), escalating doses intravenous (20–125 mg/m2) −3 and −2,...
In phase I testing, alisertib tablets with irinotecan and temozolomide showed significant antitumor activity in patients neuroblastoma. This study sought to confirm of this regimen; evaluate an oral solution; biomarkers clinical outcomes.
Diffuse intrinsic pontine gliomas (DIPGs) are lethal pediatric brain tumors. Presently, MRI is the mainstay of disease diagnosis and surveillance. We identify clinically significant computational features from create a prognostic machine learning model.We isolated tumor volumes T1-post-contrast (T1) T2-weighted (T2) MRIs 177 treatment-naïve DIPG patients an international cohort for model training testing. The Quantitative Image Feature Pipeline PyRadiomics was used feature extraction....
Purpose: We determined whether quantifying neuroblastoma-associated mRNAs (NB-mRNAs) in bone marrow and blood improves assessment of disease prediction progression patients with relapsed/refractory neuroblastoma.Experimental Design: mRNA for CHGA, DCX, DDC, PHOX2B, TH was quantified from 101 concurrently clinical evaluations. Correlation between NB-mRNA (delta cycle threshold, ΔCt, the geometric mean genes TaqMan Low Density Array NB5 assay) morphologically defined tumor cell percentage...
Abstract Neonates with complex congenital heart disease (CHD) demonstrate microstructural brain dysmaturation, but the relationship structural network topology is unknown. We performed diffusion tensor imaging (DTI) in term neonates CHD preoperatively ( N = 61) and postoperatively 50) compared healthy controls 91). used (graph) analyses incorporating different weighted unweighted approaches subject‐specific white matter segmentation to investigate differences, as well a voxel‐based analysis...
131 I-meta-iodobenzylguanidine (131 I-MIBG) is effective in relapsed neuroblastoma. The Children's Oncology Group (COG) conducted a pilot study (NCT01175356) to assess tolerability and feasibility of induction chemotherapy followed by I- MIBG therapy myeloablative busulfan/melphalan (Bu/Mel) patients with newly diagnosed high-risk neuroblastoma.Patients MIBG-avid neuroblastoma were eligible. After the first two receive protocol developed severe sinusoidal obstruction syndrome (SOS), trial...
Complex congenital heart disease (CHD) is associated with neurodevelopmental impairment, the mechanism of which unknown. Cerebral cortical dysmaturation in CHD linked to white matter abnormalities, including developmental vulnerability subplate, relation oxygen delivery and metabolism deficits. In this study, we report associations between subcortical morphology neonates using quantitative magnetic resonance imaging (MRI) spectroscopy (MRS). Multi-modal brain was performed three groups close...
Atypical teratoid/rhabdoid tumors and medulloblastomas have similar imaging histologic features but distinctly different outcomes. We hypothesized that they could be distinguished by MR imaging-based radiomic phenotypes. retrospectively assembled T2-weighted gadolinium-enhanced T1-weighted images of 48 posterior fossa atypical 96 match-paired from 7 institutions. Using a holdout test set, we measured the performance 6 candidate classifier models using derived sparse regression 900 T2WI T1WI...
<h3>BACKGROUND AND PURPOSE:</h3> Pediatric supratentorial tumors such as embryonal tumors, high-grade gliomas, and ependymomas are difficult to distinguish by histopathology imaging because of overlapping features. We applied machine learning uncover MR imaging–based radiomics phenotypes that can differentiate these tumor types. <h3>MATERIALS METHODS:</h3> Our retrospective cohort 231 patients from 7 participating institutions had 50 127 54 ependymomas. For each volume, we extracted 900...
Hodgkin lymphoma (HL) and non-Hodgkin (NHL) are both malignancies originating in the lymphatic system affect children, but many features differ considerably, impacting workup management. This paper provides consensus-based imaging recommendations for evaluation of patients with HL NHL at diagnosis response assessment interim end therapy (follow-up).
Clinicians and machine classifiers reliably diagnose pilocytic astrocytoma (PA) on magnetic resonance imaging (MRI) but less accurately distinguish medulloblastoma (MB) from ependymoma (EP). One strategy is to first rule out the most identifiable diagnosis.To hypothesize a sequential machine-learning classifier could improve diagnostic performance by mimicking clinician's of excluding PA before distinguishing MB EP.We extracted 1800 total Image Biomarker Standardization Initiative...
While COVID-19 is no longer the "hot-topic" it was 2 years ago, its prevalence and impact are still significant. In 2022, CDC estimated that over 90% of children from 6 months to 17 old have had infection. most limited mild symptoms, a substantial subset experiences significant neurological manifestations and/or complications which may lead long-lasting morbidity or even mortality. Such SARS-CoV-2 include acute encephalitis, seizures, central demyelinating disease, cerebrovascular events,...
While multiple factors impact disease, artificial intelligence (AI) studies in medicine often use small, non-diverse patient cohorts due to data sharing and privacy issues. Federated learning (FL) has emerged as a solution, enabling training across hospitals without direct sharing. Here, we present FL-PedBrain, an FL platform for pediatric posterior fossa brain tumors, evaluate its performance on diverse, realistic, multi-center cohort. Pediatric tumors were targeted the scarcity of such...
The New Approaches to Neuroblastoma Therapy Response Criteria (NANTRC) were developed optimize response assessment in patients with recurrent/refractory neuroblastoma. predictors and associations of the NANTRC version 1.0 (NANTRCv1.0) prognostic factors outcome analyzed.A retrospective analysis was performed neuroblastoma enrolled from 2000 2009 on 13 NANT Phase 1/2 trials. overall integrated CT/MRI (Response Evaluation Solid Tumors [RECIST]), metaiodobenzylguanidine (MIBG; Curie scoring),...
Abstract Neuroblastoma is the most common extracranial solid neoplasm in children. This manuscript provides consensus‐based imaging recommendations for pediatric neuroblastoma patients at diagnosis and during follow‐up.
<h3>Importance</h3> Neonatal and infant lumbar puncture is a commonly performed procedure in emergency departments, yet traumatic unsuccessful punctures occur 30% to 50% of the time. Dehydration may be risk factor for punctures, but our knowledge, no studies have investigated use intravenous (IV) fluid bolus prior puncture. <h3>Objective</h3> To investigate association IV administration with sonographic measure neonatal subarachnoid space. We hypothesized that fluids would increase space...
Abstract Background Radiolabeled metaiodobenzylguanidine (MIBG) is sensitive and specific for detecting neuroblastoma. The extent of MIBG‐avid disease assessed using Curie scores. Although scoring prognostic in patients with high‐risk neuroblastoma, there no standardized method to assess the response sites over time. goal this study was develop approaches facilitate calculation scores comparison on serial scans. Procedure We designed three semiautomated methods determining scores, each...
Abstract Childhood spinal tumors are rare. Tumors can involve the cord, meninges, bony spine, and paraspinal tissue. Optimized imaging should be utilized to evaluate arising from specific compartments. This paper provides consensus‐based recommendations for optimized of compartments at diagnosis, follow‐up during after therapy, response assessment.