A5026359229- Congenital Heart Disease Studies
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Cardiovascular Issues in Pregnancy
- Non-Invasive Vital Sign Monitoring
- Solar Radiation and Photovoltaics
- Congenital heart defects research
- Tracheal and airway disorders
- Coronary Artery Anomalies
- Advanced Neuroimaging Techniques and Applications
- Hemodynamic Monitoring and Therapy
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Aortic Disease and Treatment Approaches
- Renal and Vascular Pathologies
- Energy Load and Power Forecasting
- Hemoglobinopathies and Related Disorders
- Photovoltaic System Optimization Techniques
- Pediatric health and respiratory diseases
- Creativity in Education and Neuroscience
- Cardiac Imaging and Diagnostics
- Cystic Fibrosis Research Advances
- Family and Disability Support Research
- Cardiovascular and Diving-Related Complications
- Infant Development and Preterm Care
Children's Hospital of Los Angeles
2016-2025
University of Southern California
2018-2025
Southern California University for Professional Studies
2021
University of North Texas
2020
University of North Texas System
2020
University of North Texas Health Science Center
2020
Vietnamese-German University
2020
University of California, Los Angeles
2018
Binghamton University
2017
Boston Children's Hospital
2013
Congenital heart defects (CHD) are the leading cause of infant mortality among birth defects, and later morbidities premature remain problematic. Although genetic factors contribute significantly to CHD, specific lesions unknown for most patients. The National Heart, Lung, Blood Institute-funded Pediatric Cardiac Genomics Consortium established Heart Disease Genetic Network Study investigate relationships between factors, clinical features, outcomes in CHD. comprises 6 main 4 satellite sites...
As renewable distributed energy resources (DERs) penetrate the power grid at an accelerating speed, it is essential for operators to have accurate solar photovoltaic (PV) forecasting efficient operations and planning. Generally, observed weather data are applied in PV generation model while practice based on forecasted data. A study uncertainty most commonly used variables presented. The 6 days ahead compared with results of analysis quantified by statistical metrics. In addition,...
Objective 1st: To determine the association of cerebral oxygenation (rcSO 2 ) and concurrent neurodevelopmental outcomes between neonates with congenital heart disease (CHD) healthy controls. 2nd: examine fractional tissue oxygen extraction (FTOE) in two groups. 3rd: evaluate how type severity CHD influenced associations our primary secondary objectives. Study design Our analysis included 137 (74 63 controls). We used linear regression models to predictors (i.e., oxygenation, FTOE, CHD)...
Abstract Neonates with complex congenital heart disease (CHD) demonstrate microstructural brain dysmaturation, but the relationship structural network topology is unknown. We performed diffusion tensor imaging (DTI) in term neonates CHD preoperatively ( N = 61) and postoperatively 50) compared healthy controls 91). used (graph) analyses incorporating different weighted unweighted approaches subject‐specific white matter segmentation to investigate differences, as well a voxel‐based analysis...
Advanced brain imaging of neonatal macrostructure and microstructure, which has prognosticating importance, is more frequently being incorporated into multi-center trials neuroprotection. Multicenter neuroimaging studies, designed to overcome small sample sized clinical cohorts, are essential but lead increased technical variability. Few harmonization techniques have been developed for microstructural (diffusion tensor) analysis. The work presented here aims remedy two common problems that...
Abstract Background Tilts can induce alterations in cerebral hemodynamics healthy neonates, but prior studies have only examined systemic parameters or used small tilt angles (<90°). The neonatal population, however, are commonly subjected to large (≥90°). We sought characterize the cerebrovascular response a 90° term neonates. Methods performed secondary descriptive analysis on 44 measured oxygen saturation (rcSO 2 ), (SpO heart rate (HR), breathing (BR), and fractional tissue extraction...
Congenital heart disease (CHD) is a leading birth defect in the United States, affecting about 40 000 neonates each year. Despite efforts to prevent developmental delays, many children with CHD have neurological deficits that last into adulthood, influencing employability, self-care, and quality of life.To determine if impaired cerebral autoregulation poorer neurodevelopmental outcomes compared healthy controls.A total 44 full-term neonates, 28 16 without, were enrolled study. Inclusion...
Objective Infants with Congenital Heart Disease (CHD) are at risk for developmental delays, though the mechanisms of brain injury that impair development unknown. Potential causes could include cerebral hypoxia and cerebrovascular instability. We hypothesized we would detect significantly reduced oxygen saturation greater instability in CHD infants compared to healthy controls. Methods performed a secondary analysis on sample 43 term (28 CHD, 15 controls) assessed prospectively temporal...
Many public institutions and settings have taken action to limit exposure slow the spread of novel coronavirus (COVID-19). We sought characterize impact stay-at-home orders on our study cerebral autoregulation its association with developmental delays in infants congenital heart disease compared healthy controls.
Term congenital heart disease (CHD) neonates display abnormalities of brain structure and maturation, which are possibly related to underlying patient factors, abnormal physiology perioperative insults. Our primary goal was delineate associations between clinical factors postnatal microstructure in term CHD using diffusion tensor imaging (DTI) magnetic resonance (MR) acquisition combined with complementary data-driven connectome seed-based tractography quantitative analyses. secondary mild...
Primary ciliary dyskinesia (PCD) is an incurable, rare, inherited, chronic condition. Treatment includes the regular clearing of airway mucus, aggressive treatment infections and management hearing loss. Caregiver burden has not been explored, hence we interviewed 18 mothers 6 fathers children under years to understand impact diagnostic testing implications a positive diagnosis. Interviews were transcribed thematically analysed five key themes identified. These included parents' experiences...
Infants with congenital heart disease (CHD) may have impaired cerebral autoregulation (CA) associated fractional tissue oxygen extraction (FTOE). We conducted a pilot study in nine CHD neonates to validate noninvasive CA measure, cerebrovascular stability index (CSI), by eliciting responses postural tilts. compared CSI an invasive measure of and FTOE collected during tilts (FTOESpot). FTOESpot correlated CSI, as did the change tilts, but CSI's correlation not reach significance. Larger...
Advanced brain imaging of neonatal macrostructure and microstructure, which has prognosticating importance, is more frequently being incorporated into multi-center trials neuroprotection. Multicenter neuroimaging studies, designed to overcome small sample sized clinical cohorts, are essential but lead increased technical variability. Few harmonization techniques have been developed for microstructural (diffusion tensor) analysis. The work presented here aims remedy two common problems that...