A5010819140- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Urinary Bladder and Prostate Research
- Rheumatoid Arthritis Research and Therapies
- Urinary Tract Infections Management
- Autoimmune and Inflammatory Disorders Research
- Advanced Causal Inference Techniques
- Chronic Lymphocytic Leukemia Research
- Statistical Methods and Inference
- Biosimilars and Bioanalytical Methods
- Hernia repair and management
- Clinical practice guidelines implementation
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Body Contouring and Surgery
- Acute Myocardial Infarction Research
- Congenital Heart Disease Studies
- Dupuytren's Contracture and Treatments
- Statistical Methods in Clinical Trials
- Hip disorders and treatments
- Machine Learning in Healthcare
- Coronary Interventions and Diagnostics
- Genomics and Rare Diseases
- Diverticular Disease and Complications
- Bladder and Urothelial Cancer Treatments
Harvard Pilgrim Health Care
2024-2025
Harvard University
2024
Outcomes Research Consortium
2018
University College London
2013
Boston Children's Hospital
2013
Great Ormond Street Hospital
2013
Child Health and Development Institute
2013
New England Research Institutes
2005-2012
New England Research (United States)
2008-2011
University of California, San Diego
2008
Midurethral slings are increasingly used for the treatment of stress incontinence, but there limited data comparing types and associated complications.We performed a multicenter, randomized equivalence trial outcomes with retropubic transobturator midurethral in women incontinence. The primary outcome was success at 12 months according to both objective criteria (a negative test, pad no retreatment) subjective (self-reported absence symptoms, leakage episodes recorded, retreatment)....
Many surgical procedures are available for women with urinary stress incontinence, yet few randomized clinical trials have been conducted to provide a basis treatment recommendations.We performed multicenter, trial comparing two procedures--the pubovaginal sling, using autologous rectus fascia, and the Burch colposuspension--among incontinence. Women were eligible study if they had predominant symptoms associated condition, positive test, urethral hypermobility. The primary outcomes success...
Urodynamic studies are commonly performed in women before surgery for stress urinary incontinence, but there is no good evidence that they improve outcomes.
Objective Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We compared 5‐year adverse event (AE) incidence rates (IRs) between patients initiating tofacitinib and those new biological disease‐modifying antirheumatic drugs (bDMARDs) within United States (US) Corrona RA registry. Methods IRs (number first events/100 patient‐years) major cardiovascular events (MACE), serious infection (SIEs), herpes zoster (HZ), malignancies, death were estimated...
Congenital heart defects (CHD) are the leading cause of infant mortality among birth defects, and later morbidities premature remain problematic. Although genetic factors contribute significantly to CHD, specific lesions unknown for most patients. The National Heart, Lung, Blood Institute-funded Pediatric Cardiac Genomics Consortium established Heart Disease Genetic Network Study investigate relationships between factors, clinical features, outcomes in CHD. comprises 6 main 4 satellite sites...
Background: Women with urge urinary incontinence are commonly treated antimuscarinic medications, but many discontinue therapy. Objective: To determine whether combining drug therapy supervised behavioral training, compared alone, improves the ability of women to achieve clinically important reductions in episodes and sustain these improvements after discontinuing Design: 2-stage, multicenter, randomized clinical trial conducted from July 2004 January 2006. Setting: 9 university-affiliated...
In Brief OBJECTIVE: To identify clinical and demographic factors predictive of midurethral sling failure. METHODS: Overall treatment failure was defined by one or more the following objective outcomes: a positive stress test, 24-hour pad test retreatment for urinary incontinence (SUI); subjective self reported SUI Medical, Epidemiologic Social Aspect Aging questionnaire, incontinent episodes 3-day diary, SUI, combination these. Logistic regression models adjusting type site were used to...
We compared urinary incontinence severity measures and the impact of stress in normal, overweight obese women.
Partially observed confounder data pose a major challenge in statistical analyses aimed to inform causal inference using electronic health records (EHRs). While analytic approaches such as imputation are available, assumptions on underlying missingness patterns and mechanisms must be verified. We develop toolkit streamline missing diagnostics guide choice of based meeting necessary assumptions.
We assessed the relationships among severity measures of urinary incontinence in women with stress predominant symptoms enrolled a randomized clinical trial comparing 2 surgical techniques (Burch colposuspension vs pubovaginal sling) for incontinence.A total 655 underwent standardized preoperative assessment that included Medical, Epidemiological and Social Aspects Aging questionnaire, Urogenital Distress Inventory, Incontinence Impact Questionnaire, 3-day voiding diary, 24-hour pad test,...
No published studies exist comparing the effectiveness of tofacitinib with other advanced therapies for treatment rheumatoid arthritis (RA) in real-world clinical practice. Here, we report differences compared standard care, tumor necrosis factor inhibitors (TNFi), or without concomitant methotrexate (MTX), using US Corrona registry data.
Registry studies provide a valuable source of comparative safety data for tumor necrosis factor inhibitors (TNFi) used in rheumatoid arthritis (RA), but they are subject to channeling bias. Comparing outcomes without accounting bias can lead inaccurate comparisons between TNFi prescribed at different stages the disease. In present study, we examined incidence serious infection and other adverse events during certolizumab pegol (CZP) use vs U.S. RA cohort before after using methodological...
Abstract Multiple imputation (MI) models can be improved with auxiliary covariates (AC), but their performance in high-dimensional data remains unclear. We aimed to develop and compare MI (HDMI) methods using structured natural language processing (NLP)-derived AC studies partially observed confounders. conducted a plasmode simulation acute kidney injury as outcome simulated 100 cohorts null treatment effect, incorporating creatinine labs, atrial fibrillation (AFib), other...
In Brief OBJECTIVE: To estimate whether perioperative and postoperative outcomes after Burch colposuspension or pubovaginal sling for stress urinary incontinence (SUI) differed with age. METHODS: This study was a prospective secondary analysis of the Stress Incontinence Surgical Treatment Efficacy Trial. Baseline characteristics, adverse events, 2-year women at least 65 years old were compared those younger than using χ2 t tests. Multivariable analyses performed, including age that between...
Objective: Partially observed confounder data pose challenges to the statistical analysis of electronic health records (EHR) and systematic assessments potentially underlying missingness mechanisms are lacking. We aimed provide a principled approach empirically characterize missing processes investigate performance analytic methods. Methods: Three empirical sub-cohorts diabetic SGLT2 or DPP4-inhibitor initiators with complete information on HbA1c, BMI smoking as confounders interest (COI)...
We determined the clinicodemographic factors associated with complications of continence procedures, impact concomitant surgery on complication rate and relationship between incidence cystitis method postoperative bladder drainage.We reviewed serious adverse events in Stress Incontinence Surgical Efficacy Trial, a randomized trial comparing Burch colposuspension to autologous rectus fascial sling. Clinicodemographic variables were analyzed determine those using logistic regression analysis....
To describe perineal surface patch electromyography (EMG) activity during urodynamics (UDS) and compare between filling voiding phases to assess for a relationship preoperative EMG postoperative symptoms.655 women underwent standardized UDS that included prior undergoing surgery stress urinary incontinence. Pressure-flow studies were evaluated abdominal straining interrupted flow. Quantitative values extracted from 10 predetermined time-points compared fill void. Qualitative was assessed the...
The aim of this study was to determine whether preoperative voiding detrusor pressures were associated with postoperative outcomes after stress incontinence surgery.Opening pressure, pressure at maximum flow (p (det) Q(max)), and closing assessed from 280 valid urodynamic studies in subjects without advanced prolapse a multicenter randomized trial comparing Burch autologous fascia sling procedures. These compared between overall success, stress-specific overactivity, urge using independent...
<h3>Background:</h3> Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). Real-world data (RWD) complement clinical trial in assessing long-term safety. To our knowledge, this first comparative RWD analysis tofacitinib. <h3>Objectives:</h3> compare 5-year adverse event (AE) incidence rates (IRs) patients (pts) starting tofacitinib vs biological (b)DMARDs using cohorts from US Corrona RA registry. <h3>Methods:</h3> This prospective, observational study embedded...