A5009688412- Rheumatoid Arthritis Research and Therapies
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Advanced Causal Inference Techniques
- Maternal Mental Health During Pregnancy and Postpartum
- Viral gastroenteritis research and epidemiology
- Medication Adherence and Compliance
- Statistical Methods in Clinical Trials
- Biosimilars and Bioanalytical Methods
- Prenatal Substance Exposure Effects
- Viral Infections and Immunology Research
- Opioid Use Disorder Treatment
- Pharmaceutical Economics and Policy
- Autoimmune and Inflammatory Disorders Research
- Machine Learning in Healthcare
- Cardiovascular Function and Risk Factors
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Policy and Management
- Pharmacological Effects and Toxicity Studies
- Gout, Hyperuricemia, Uric Acid
- Systemic Sclerosis and Related Diseases
- Blood Pressure and Hypertension Studies
- Pregnancy and preeclampsia studies
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Sify Technologies (India)
2024
Pharmac
2015-2023
Analysis Group (United States)
2023
RELX Group (Netherlands)
2023
RELX Group (United States)
2023
Dwarkadas J. Sanghvi College of Engineering
2021-2022
Wake Research
2022
Stanford University
2018-2021
This report aims to provide methodological guidance help practitioners select the most appropriate weighting method based on propensity scores for their analysis out of many available options (eg, inverse probability treatment weights, standardised mortality ratio fine stratification overlap and matching weights), outlines recommendations transparent reporting studies using scores.
Abstract Here we identify hundreds of new drug-disease associations for over 900 FDA-approved drugs by quantifying the network proximity disease genes and drug targets in human (protein–protein) interactome. We select four network-predicted to test their causal relationship using large healthcare databases with 220 million patients state-of-the-art pharmacoepidemiologic analyses. Using propensity score matching, two network-based predictions are validated patient-level data: carbamazepine is...
In Brief OBJECTIVE: To report the prevalence of prescription opioid use and evaluate trends in a large cohort Medicaid-enrolled pregnant women. METHODS: A pregnancies was identified using data from Medicaid Analytical eXtract for period 2000–2007. Dispensing opioids, as class separately individual agents, evaluated claims filled prescriptions. Variations patterns fills were examined by demographic characteristics, geographic region, over time. Median number prescriptions dispensed cumulative...
<h3>Importance</h3> The frequency of antipsychotic (AP) use during pregnancy has approximately doubled the last decade. However, little is known about their safety for developing fetus, and concerns have been raised a potential association with congenital malformations. <h3>Objective</h3> To examine risk malformations overall cardiac associated first-trimester exposure to APs. <h3>Design, Setting, Participants</h3> This nationwide sample 1 360 101 pregnant women enrolled in Medicaid...
Regulators are evaluating the use of noninterventional real-world evidence (RWE) studies to assess effectiveness medical products. The RCT DUPLICATE initiative (Randomized, Controlled Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques Epidemiology) uses a structured process design RWE emulating randomized, controlled trials (RCTs) and compare results. We report findings first 10 trial emulations, cardiovascular outcomes antidiabetic or antiplatelet...
<h3>Importance</h3> The association between selective serotonin reuptake inhibitor (SSRI) antidepressant use during pregnancy and risk of persistent pulmonary hypertension the newborn (PPHN) has been controversial since US Food Drug Administration issued a public health advisory in 2006. <h3>Objective</h3> To examine PPHN associated with exposure to different medication classes late pregnancy. <h3>Design Setting</h3> Cohort study nested 2000-2010 Medicaid Analytic eXtract for 46 states...
There has been concern that exposure to lithium early in pregnancy may be associated with a marked increase the risk of Ebstein's anomaly (a right ventricular outflow tract obstruction defect) infants and overall congenital cardiac defects, but data are conflicting limited.
<h3>Importance</h3> Accurate risk stratification of patients with heart failure (HF) is critical to deploy targeted interventions aimed at improving patients' quality life and outcomes. <h3>Objectives</h3> To compare machine learning approaches traditional logistic regression in predicting key outcomes HF evaluate the added value augmenting claims-based predictive models electronic medical record (EMR)–derived information. <h3>Design, Setting, Participants</h3> A prognostic study a 1-year...
Importance Nonrandomized studies using insurance claims databases can be analyzed to produce real-world evidence on the effectiveness of medical products. Given lack baseline randomization and measurement issues, concerns exist about whether such unbiased treatment effect estimates. Objective To emulate design 30 completed 2 ongoing randomized clinical trials (RCTs) medications with database observational analogues RCT parameters (population, intervention, comparator, outcome, time [PICOT])...
<b>Objective</b> To examine the teratogenic potential of statins. <b>Design</b> Cohort study. <b>Setting</b> United States. <b>Participants</b> A cohort 886 996 completed pregnancies linked to liveborn infants women enrolled in Medicaid from 2000 2007. <b>Methods</b> We examined risk major congenital malformations and organ specific offspring associated with maternal use a statin first trimester. Propensity score based methods were used control for confounders, including demographic...
When exposure is infrequent, propensity-score matching results in reduced precision because it discards a large proportion of unexposed patients. To our knowledge, the relative performance stratification these circumstances has not been examined.Using an empirical example association first trimester statin (prevalence = 0.04%) with risk congenital malformations and 1,000 simulated cohorts (n 20,000) eight combinations prevalence (0.5%, 1%, 5%, 10%) outcome (3.5%, 10%), we compared four...
Objective To investigate the rate of serious bacterial, viral or opportunistic infection in patients with rheumatoid arthritis (RA) starting tocilizumab (TCZ) versus tumour necrosis factor inhibitors (TNFi) abatacept. Methods Using claims data from US Medicare 2010 to 2015, and IMS MarketScan 2011 we identified adults RA who initiated TCZ TNFi (primary comparator)/abatacept (secondary comparator) prior use ≥1 different biologic drug tofacitinib. The primary outcome was hospitalised (SI),...
Recent results from 'ORAL Surveillance' trial have raised concerns regarding the cardiovascular safety of tofacitinib in patients with rheumatoid arthritis (RA). We further examined this concern real-world setting.
This report proposes a stepwise process covering the range of considerations to systematically consider key choices for study design and data analysis non-interventional studies with central objective fostering generation reliable reproducible evidence. These steps include (1) formulating well defined causal question via specification target trial protocol; (2) describing emulation each component protocol identifying fit-for-purpose data; (3) assessing expected precision conducting...
To provide absolute and relative risk estimates of neonatal abstinence syndrome (NAS) based on duration timing prescription opioid use during pregnancy in the presence or absence additional NAS factors history misuse dependence, other substances, non-opioid psychotropic drug use, smoking.
<b>Objectives</b> To assess the impact of in utero co-exposure to psychotropic medications and opioids on incidence severity neonatal drug withdrawal. <b>Design</b> Observational cohort study. <b>Setting</b> Nationwide sample pregnancies publicly insured women US, nested Medicaid Analytic eXtract (2000-10). <b>Participants</b> 201 275 pregnant with public insurance who were exposed around time delivery their liveborn infants. <b>Interventions</b> In exposure...
Background: Hyperuricemia and gout are associated with an increased risk of cardiovascular disease. Xanthine oxidase inhibitors, allopurinol febuxostat, the mainstay urate-lowering treatment for may have different effects on in patients gout. Methods: Using US Medicare claims data (2008–2013), we conducted a cohort study comparative safety initiating febuxostat versus among ≥65 years age. The primary outcome was composite end point hospitalization myocardial infarction or stroke. Secondary...
Medical education videos can enhance learning and easily integrate into common instructional methods. YouTube permits worldwide access to high-quality medical videos; however, no studies have described the reach of on or what topics are preferred.One year analytics data (February 1, 2016, January 31, 2017) was collected for a medical-education-focused channel called Osmosis. Created December 20, 2015, had 189 disease-focused by 2017. Viewer subscriber were analyzed according World Bank's...
<h3>Importance</h3> Evidence for the fetal safety of ondansetron, a 5-HT<sub>3</sub>receptor antagonist that is commonly prescribed nausea and vomiting during pregnancy, limited conflicting. <h3>Objective</h3> To evaluate association between ondansetron exposure pregnancy risk congenital malformations. <h3>Design, Setting, Participants</h3> A retrospective cohort study nested in 2000-2013 nationwide Medicaid Analytic eXtract. The consisted 1 816 414 pregnancies contributed by 502 895 women...
BACKGROUND AND OBJECTIVES: β blockers are widely used in the treatment of hypertensive disorders during pregnancy. These medications cross placenta and may cause physiologic changes neonates exposed utero. We sought to define risks neonatal hypoglycemia bradycardia associated with maternal exposure at time delivery a large, nationwide cohort Medicaid beneficiaries. METHODS: 2 292 116 completed pregnancies linked liveborn infants Medicaid-enrolled women from 2003 2007. examined delivery....
Objective To evaluate the risk of venous thromboembolism ( VTE ) in rheumatoid arthritis RA patients receiving tofacitinib versus those tumor necrosis factor TNF inhibitors. Methods who were initiating treatment with or a inhibitor and had not previously received any biologic agent identified from Truven MarketScan database (2012–2016) Medicare claims (parts A, B, D) (2012–2015). Patients followed up until discontinuation, switch, insurance disenrollment, administrative censoring. The...