Summary Background Clinical approaches to treating childhood obesity can be expensive and poorly reimbursed, often produce suboptimal results. It has been theorized that overeating may have addictive qualities, a sizable number of adolescents with endorse habits. Interestingly, few weight management interventions tested techniques founded in addiction medicine principles. We therefore performed pilot study an model based mHealth loss intervention adolescents. Methods Adolescents were...

Due to its simplicity, time-limited eating (TLE) may represent a more feasible approach for treating adolescents with obesity compared other caloric restriction regimens. This pilot study examines the feasibility and safety of TLE combined continuous glucose monitoring (CGM) in adolescents. Fifty BMI ≥95th percentile were recruited complete 12-week study. All received standard nutritional counseling, wore CGM daily, randomized to: (1) Prolonged window: 12 h eating/12 fasting + blinded CGM;...

Background Randomized controlled trials of time restricted eating (TRE) in adults have demonstrated improvements glucose variability as captured by continuous monitors (CGM). However, little is known about the feasibility CGM use TRE interventions adolescents, or expected changes glycemic profiles response to meal-timing. As part a pilot trial adolescents with obesity, this study aimed 1) assess use, 2) describe baseline without diabetes, and 3) compare difference between groups practicing...

Abstract Purpose The purpose of this retrospective cohort analysis was to investigate sex differences in receipt standard care sleep and constipation drug treatments among autistic children youth with disorder constipation, respectively. Methods We used the data from OneFlorida + Data Trust analyze healthcare claims for 19,877 patients 32,355 ages 1 22. logistic regression examine receiving treatments, a multivariate model further assess ever adjusting age, race, ethnicity, urbanicity....

Diagnosis of B-cell acute lymphoblastic leukemia (B-ALL) requires immunophenotypic evidence B-lineage and absence specific myeloid or T-lineage markers. Rare cases otherwise typical B-ALL express myeloperoxidase (MPO) detectable by flow cytometry with an other markers, but the clinical significance this finding is not well studied.A retrospective cohort analysis data was performed to investigate outcome group patients.Twenty-nine that expressed MPO (B-ALL-isoMPO) without expression markers...

Background Bleomycin is associated with pulmonary toxic side effects including pneumonitis and fibrosis. We evaluated the prevalence of long-term function abnormalities in children receiving bleomycin therapy context current chemotherapeutic regimens. Methods A retrospective review patients who received between January 1999 December 2011 was conducted. Abnormalities most recent test (PFT) at least 1 year after diagnosis were analyzed. Results Two-hundred seven had bleomycin. The results PFT...

Introduction Emicizumab is a humanized bispecific monoclonal antibody licensed for patients with severe haemophilia A and without inhibitors. Management of breakthrough bleeding in inhibitors on emicizumab involves episodic treatment bypassing agents (BPA), activated prothrombin complex concentrate (aPCC) or recombinant factor VII (rFVIIa). Thrombotic events thrombotic microangiopathy were reported when received concomitant aPCC at relatively high doses yet such not rFVIIa. We studied the...

Universal implementation of cystic fibrosis (CF) newborn screening (NBS) has led to the diagnostic dilemma infants with CF screen-positive, inconclusive diagnosis (CFSPID), limited guidance regarding prognosis and standardized care. Rates reclassification from CFSPID vary risk factors for are not well established. We investigated whether clinical characteristics associated a diagnosis.Children positive NBS were recruited two sites in California. Retrospective, longitudinal, cross-sectional...

Recent technological advances have led to the capability of performing high resolution imaging tympanic membrane. Smartphone technologies and applications provided opportunity capture digital images easily share them. The smartphone otoscope device was developed as a simple system that can convert into otoscope. This has prospective ability improve physician-patient communication assist with diagnosis management ear disease. Our objective evaluate feasibility physician/parental satisfaction...

High elbow varus torque during baseball pitching has been identified as a potential cause of ulnar collateral ligament injury in pitchers. In general, increases ball velocity across However, studies incorporating within-subject analyses report that not all professional pitchers have positive relationship between and (T-V relationship). It remains unknown whether collegiate show the same trend professionals their T-V relationships. The current study investigated focusing on both within...

Objective: This study examines changes in the Yale Food Addiction Scale symptom count over a 24-week, weight-loss mobile Health (mHealth) intervention incorporating elements of addiction medicine. Methods: Adolescents (n = 117) with obesity (15.5 ± 1.3 years; 66% Hispanic) were randomized to following: (1) mHealth (AppAlone), (2) intervention+coaching (AppCoach), or (3) in-person (Control). A multivariate mixed Poisson regression model was used evaluate counts across arms after adjusting for...

The Fontan procedure for univentricular heart defects creates a nonphysiologic circulation where systemic venous blood drains directly into the pulmonary arteries, leading to multiorgan dysfunction secondary chronic low-shear nonpulsatile flow and central hypertension. Although viscosity increases exponentially in this environment, role of shear-dependent (“non-Newtonian”) pathophysiology is unclear. We studied three-dimensional (3D)-printed models an vitro loop with Philips 3-T magnetic...

Objective Infants with Congenital Heart Disease (CHD) are at risk for developmental delays, though the mechanisms of brain injury that impair development unknown. Potential causes could include cerebral hypoxia and cerebrovascular instability. We hypothesized we would detect significantly reduced oxygen saturation greater instability in CHD infants compared to healthy controls. Methods performed a secondary analysis on sample 43 term (28 CHD, 15 controls) assessed prospectively temporal...

Sensitization to (meth)acrylates, the most common nail cosmetic allergens, is rising. In recent years, home acrylic kits have become easily available.

Management of obstructive sleep apnea in infants with Robin sequence (RS) includes prone positioning during sleep, which conflicts safe infant data. We examined changes polysomnography (PSG) parameters for versus nonprone body positions these infants.Pre-post interventional, nonblinded study.Infants RS referred PSG were recruited from craniofacial clinic and inpatient units at Children's Hospital Los Angeles, a tertiary pediatric center. Fourteen recruited, 12 studies completed on both...

<b><i>Introduction:</i></b> To date, there has been no study investigating how meal-timing impacts glucose and insulin resistance among Latino youth at high risk of type 2 diabetes. A proof-of-concept was conducted to assess metabolic response a test-meal consumed in the morning, afternoon, evening 15 adolescents with obesity using within-participant design. <b><i>Methods:</i></b> Youth, 13–19 years age, obesity, same after 16 h fast three...