A5070754345- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Blood disorders and treatments
- Autophagy in Disease and Therapy
- Diabetic Foot Ulcer Assessment and Management
- Autoimmune Bullous Skin Diseases
- Bone and Joint Diseases
- Acute Lymphoblastic Leukemia research
- Otitis Media and Relapsing Polychondritis
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- T-cell and Retrovirus Studies
- NF-κB Signaling Pathways
- Chronic Myeloid Leukemia Treatments
- Cardiac tumors and thrombi
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Melanoma and MAPK Pathways
- Platelet Disorders and Treatments
University of Southern California
2015-2024
Southern California University for Professional Studies
2022
University of California, Davis
2022
LAC+USC Medical Center
2017
Children's Hospital of Los Angeles
2016
Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAFV600E-melanoma, autophagy by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated the TFEB transcription factor. phosphorylated thus inactivated BRAFV600E via downstream ERK independently mTORC1. BRAFi disrupts phosphorylation, allowing nuclear translocation, which...
Diagnosis of B-cell acute lymphoblastic leukemia (B-ALL) requires immunophenotypic evidence B-lineage and absence specific myeloid or T-lineage markers. Rare cases otherwise typical B-ALL express myeloperoxidase (MPO) detectable by flow cytometry with an other markers, but the clinical significance this finding is not well studied.A retrospective cohort analysis data was performed to investigate outcome group patients.Twenty-nine that expressed MPO (B-ALL-isoMPO) without expression markers...
Aberrant autophagy is a major risk factor for inflammatory diseases and cancer. However, the genetic basis underlying mechanisms are less established. UVRAG tumor suppressor candidate involved in autophagy, which truncated cancers by frameshift (FS) mutation expressed as shortened
Abstract Introduction Evaluation of cellularity is an essential component bone marrow trephine biopsy examination. The standard practice to report the results as visual estimates (VE). Digital image analysis (DIA) offers promise more objective measurements cellularity. Methods Adult sections were assessed for by VE. Sections scanned using Aperio AT2 Scanscope and analyzed a Cytonuclear (version 1.4) algorithm on halo software. Intraclass correlation (ICC) was used assess relatedness between...
Abstract Objectives To discuss VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, including the clinical and pathologic features, diagnostic challenges, treatment options. Methods A case-based approach pertinent literature review were used to highlight features of describe how make diagnosis, available therapies. Results syndrome is an adult-onset, progressive systemic inflammatory disorder with overlapping rheumatologic hematologic manifestations, increased risk...
Immune checkpoint inhibitors have recently emerged as important and effective advanced cancer treatment options. Programmed cell death receptor-1 (PD-1) antagonists such pembrolizumab nivolumab been approved by the US Food Drug Administration for of many cancers. As anti-PD-1 inhibitor use has increasing, previously unreported rare side effects emerge. These upregulate humoral cellular immune responses to tumor antigens. Consequently, they can be associated with immune-related adverse events...
Anti-interferon-gamma autoantibody-associated immunodeficiency syndrome is a rare and underrecognized adult onset associated with severe opportunistic infections such as disseminated nontuberculous mycobacterium. Few cases have documented relationship IgG4-related disease. Concomitant diagnoses of these diseases present diagnostic management challenge.A 61 year old man Southeast Asian descent pulmonary mycobacterium avium complex infection presented to our hospital system new skin rash...
This case report aimed to review the bone marrow features of patients with acute myeloid leukemia (AML) treated isocitrate dehydrogenase 1/2 (IDH1/2) inhibitors. Five AML an IDH1/2 inhibitor were identified and retrospectively reviewed. We described morphologic immunophenotypic findings in marrow, as well ancillary study results. Two showed a hypercellular differentiation blasts. The one patient displayed hypoplastic phase. Four five demonstrated unusual and/or populations, including...
Abstract Background Clonal cytopenia of undetermined significance (CCUS) is defined as somatic mutations myeloid malignancy‐associated genes in the blood or bone marrow with one more persistent unexplained cytopenias that do not meet diagnostic criteria for a neoplasm. CCUS isolated thrombocytopenia (CCUS‐IT) rare. Methods This retrospective case series patients prolonged thrombocytopenia, pathogenic mutation on molecular panel, and biopsy morphologic atypia below WHO‐defined threshold...
Abstract Background Anti-interferon-gamma autoantibody-associated immunodeficiency syndrome is a rare and underrecognized adult onset associated with severe opportunistic infections such as disseminated nontuberculous mycobacterium. Few cases have documented relationship IgG4-related disease. Concomitant diagnoses of these diseases present diagnostic management challenge. Case Presentation: A 61 year old man Southeast Asian descent pulmonary mycobacterium avium complex infection presented to...