A5037337293- Pituitary Gland Disorders and Treatments
- Single-cell and spatial transcriptomics
- Congenital heart defects research
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Adrenal and Paraganglionic Tumors
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
- RNA regulation and disease
- Advanced Glycation End Products research
- Viral Infections and Immunology Research
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Mechanisms of cancer metastasis
- RNA Research and Splicing
- Telomeres, Telomerase, and Senescence
- Chromatin Remodeling and Cancer
- TGF-β signaling in diseases
Max Planck Institute of Experimental Medicine
2024
University College London
2017-2023
Great Ormond Street Hospital
2017-2021
The accumulation of senescent cells in the tumor microenvironment can drive tumorigenesis a paracrine manner through senescence-associated secretory phenotype (SASP). Using new p16-FDR mouse line, we show that macrophages and endothelial are predominant cell types murine KRAS-driven lung tumors. Through single transcriptomics, identify population tumor-associated express unique array pro-tumorigenic SASP factors surface proteins also present normal aged lungs. Genetic or senolytic ablation...
Adamantinomatous craniopharyngiomas (ACPs) are clinically challenging tumours, the majority of which have activating mutations in CTNNB1. They histologically complex, showing cystic and solid components, latter comprised different morphological cell types (e.g. β-catenin-accumulating cluster cells palisading epithelium), surrounded by a florid glial reaction with immune cells. Here, we carried out RNA sequencing on 18 ACP samples integrated these data an existing transcriptomic dataset. No...
Despite the importance of RAS-RAF-MAPK pathway in normal physiology and disease numerous organs, its role during pituitary development tumourigenesis remains largely unknown. Here we show that over-activation MAPK pathway, through conditional expression gain-of-function alleles BrafV600E KrasG12D developing mouse pituitary, results severe hyperplasia abnormal morphogenesis gland by end gestation. Cell-lineage commitment terminal differentiation are disrupted, leading to a significant...
Abstract Adamantinomatous Craniopharyngioma (ACP) is a rare pituitary tumor of the sellar region, with bimodal presentation pattern in children and middle-aged adults. ACPs are primarily driven by mutation CTNNB1 that prevents beta-catenin from degrading properly, resulting accumulation nuclei epithelial whorl-like structures sometimes referred to as cluster cells. Clinical management challenging due location tumor, such complete surgical resection often not possible so radiation therapy,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Introduction Hormone-producing pituitary cell lineages are derived from a population of embryonic precursors expressing SOX2. These cells maintain multipotency into early postnatal life, acting as the resident stem (PSCs) and contributing extensively to all endocrine lineages. In addition this direct contribution turnover, paracrine signalling PSCs has been shown be important for proliferation neighbouring progenitors (PMC7803373). It is not known if SOX2+ involved in regulation...
Abstract The pituitary gland is the master regulator of endocrine system, housing six major hormone producing cell types. This derived from Rathke’s Pouch, an invagination oral ectoderm. Hormone-producing lineages are a population embryonic cells expressing SOX2. ZFP36L1/Butyrate Response Factor 1 (BRF1) RNA binding protein that binds and targets mRNAs various cytokines chemokines for degradation prior to translation, attenuating secretion inflammatory factors (Herranz et al. 2015). Here, we...