A5031562318- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Dialysis and Renal Disease Management
- Eosinophilic Disorders and Syndromes
- Acute Lymphoblastic Leukemia research
- Renal Transplantation Outcomes and Treatments
- Hematopoietic Stem Cell Transplantation
- Telomeres, Telomerase, and Senescence
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Clostridium difficile and Clostridium perfringens research
- Blood groups and transfusion
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Reproductive System and Pregnancy
- Kruppel-like factors research
- Complement system in diseases
- Chronic Kidney Disease and Diabetes
- Neutropenia and Cancer Infections
- Genetics, Aging, and Longevity in Model Organisms
- Multiple Myeloma Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
Imperial College Healthcare NHS Trust
2011-2024
Hammersmith Hospital
2015-2024
Imperial College London
2015-2024
MRC London Institute of Medical Sciences
2018-2023
The Royal Melbourne Hospital
2020
University of Auckland
2020
National Health Service
2019
Newcastle University
2018
University Hospital Crosshouse
2008-2013
Raigmore Hospital
2012
BackgroundThe London patient (participant 36 in the IciStem cohort) underwent allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); remission was reported at 18 months after analytical treatment interruption (ATI). Here, we present longer term data for this (up to 30 ATI), including sampling from diverse HIV-1 reservoir sites.MethodsWe used ultrasensitive viral load assays of plasma, semen, and cerebrospinal fluid (CSF) samples detect RNA. In gut biopsy...
Forty-four patients who commenced renal replacement therapy between January 1983 and 1988 died within 1 year of starting treatment. To examine the factors influencing early mortality on these (group A) were compared with a group 44 ageand sex-matched subjects started dialysis over same period survived more than B). The interval first presentation was significantly shorter in A (median 36 days) B 30 months) patients. Plasma urea creatinine greater at time to nephrologist but not dialysis....
Calciphylaxis is a rare but serious complication of end-stage renal failure, which has high mortality due to widespread vascular calcification and refractory infections [1,2]. Parathyroidectomy been advocated as one the few treatments that may reverse this condition [3], although not universally accepted always successful [4]. The newly developed calcimimetic, cinacalcet (marketed Mimpara in EU, Sensipar USA by Amgen Inc., Thousand Oaks, CA, USA) produces rapid biochemical control secondary...
Background: Central venous catheters (CVC) are a potential source of bacteraemia and have been associated with increased mortality in haemodialysis patients. We aimed to investigate the relationships between vascular access, taking into account changes access type during patients' lives, cause specific risk national cohort dialysis Methods: Prospective study including all patients receiving Scotland at annual cross sectional surveys 2009, 2010 2011. Data were collected through Scottish Renal...
Abstract Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay 20 patients colonized/infected with MDRO receiving FMT (compared pre-FMT history, a matched group not FMT), despite modest rates.
Abstract Second-generation tyrosine kinase inhibitors (2GTKI) are more effective in inducing rapid molecular responses than imatinib when used first-line patients with chronic myeloid leukemia phase (CML-CP). However, failure of first line-2GTKI (1L-2GTKI) still occurs and there is no consensus regarding subsequent management. We retrospectively analyzed the outcome 106 CML-CP treated 1L-2GTKI a median follow-up 91 months. 45 (42.4%) switched to an alternative TKI, 28 for intolerance (26.4%)...
Cardiovascular disease is a leading cause of death in the UK. The flavonoids found cocoa may produce cardio-protective role for chocolate with high content. Thirty healthy volunteers were randomised to receive 100 g white, milk or dark chocolate, and assessments platelet function undertaken on venous blood samples before after consumption. White had no significant effect platelets. However inhibited collagen-induced aggregation rich plasma. In future have prevention cardiovascular...
BACKGROUND: Long, slow haemodialysis (24 h/week) has been associated with excellent patient survival and reduced cardiovascular mortality. Comparisons of have only possible registry data other published series which do not control for individual characteristics. This retrospective study compares actuarial between a unit using long, (Tassin) one employing 'conventional' (Nottingham). METHODS: All patients undergoing at each centre since 1980 were included (Tassin, 452 patients; Nottingham,...
Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and relatively common following HLA-haploidentical transplantation. Adoptive immunotransfer virus-specific T cells from the donor promising therapeutic approach, although production these challenging, particularly when dealing with low-frequency such as BKV-specific cells.Here, we present patient who, haploidentical HCT, developed severe BKV haemorrhagic cystitis,...
The gut microbiome can be adversely affected by chemotherapy and antibiotics prior to hematopoietic cell transplantation (HCT). This affects graft success increases susceptibility multidrug-resistant organism (MDRO) colonization infection. We performed an initial retrospective analysis of our use fecal microbiota (FMT) from healthy donors as therapy for MDRO-colonized patients with hematological malignancy. FMT was on eight pre-HCT (FMT-MDRO group), outcomes compared 11 MDRO colonized HCT...
BackgroundPatients receiving treatment with renal replacement therapy (RRT) have high mortality, and ensuring patient safety in this population is difficult. We aimed to estimate the incidence nature of medical adverse events contributing death patients being treated RRT.
Early and accurate treatment of infections due to carbapenem-resistant organisms is facilitated by rapid diagnostics, but rare resistance mechanisms can compromise detection. One year after a Guiana Extended-Spectrum (GES)-5 carbapenemase-positive Klebsiella oxytoca infection was identified whole-genome sequencing (WGS; later found be part cluster 3 cases), 11 patients with GES-5-positive K. over 18 weeks in the same hospital.Bacteria were matrix-assisted laser desorption/ionization-time...
Summary Targeted therapy for chronic myeloid leukaemia (CML) has allowed a near‐normal patient life‐expectancy; however, quality of life and aggravation existing co‐morbidities have posed new treatment challenges. In clinical practice, TKI dose reduction occurs frequently, often on multiple occasions, because intolerance. We conducted retrospective ‘real‐world practice’ review 246 patients receiving lower than standard (LD) after the achievement major molecular response (MR3), intolerable...
Patients with haematological malignancies have a high risk of severe infection and death from SARS-CoV-2. In this prospective observational study, we investigated the impact cancer type, disease activity, treatment in 877 unvaccinated UK patients SARS-CoV-2 active cancer. The primary end-point was all-cause mortality. multivariate analysis adjusted for age, sex comorbidities, highest mortality acute leukaemia [odds ratio (OR) = 1·73, 95% confidence interval (CI) 1·1-2·72, P 0·017] myeloma...
Advancements in the management of patients with chronic myeloid leukemia (CML) allowed them to achieve survival comparable their healthy counterparts. Consequently, care has widened growing focus on quality life, including parenting children. Although tyrosine kinase inhibitors (TKI) are contraindicated pregnancy given teratogenic effect, effect male fertility is less clear contradictory results from animal studies and case reports/series. We compared sperm analysis parameters, as...
Summary Diagnosing chronic myeloid leukaemia (CML) during pregnancy is rare. Tyrosine kinase inhibitors (TKIs) have traditionally been contraindicated owing to their teratogenicity. Management decisions should consider the risks mother and foetus of uncontrolled disease teratogenic medications. Further cases are required build upon paucity current literature. We report 22 CML diagnosed from 2002 date. Twenty‐one pregnancies resulted in healthy babies one patient miscarried. Some patients...
The therapeutic landscape of chronic myeloid leukaemia (CML) has been transformed by tyrosine kinase inhibitors (TKI). Nilotinib, showed higher rates major molecular response than imatinib, however associated with cardiovascular (CV) toxicity. We sought to describe the CV events nilotinib in a real-world population and assess predictive value HFA-ICOS risk score.