A5009388487- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Gallbladder and Bile Duct Disorders
- Gastroesophageal reflux and treatments
- Renal function and acid-base balance
- Acute Kidney Injury Research
- Gastric Cancer Management and Outcomes
- Dermatological and COVID-19 studies
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Liver Diseases and Immunity
- Foreign Body Medical Cases
- Hepatitis B Virus Studies
- Diagnosis and treatment of tuberculosis
- Biliary and Gastrointestinal Fistulas
- COVID-19 Clinical Research Studies
Govind Ballabh Pant Hospital
2019-2024
Maulana Azad Medical College
2011-2023
Institute of Post Graduate Medical Education and Research
2019-2023
Medanta The Medicity
2023
All India Institute of Medical Sciences
2014-2021
Unité de Nutrition Humaine
2016
Abstract Background and Aims Data on the use of intravenous L‐ornithine L‐aspartate (LOLA) in treatment overt HE (OHE) is limited. We evaluated role LOLA patients cirrhosis with OHE grade III–IV. Approach Results In a double‐blind randomized placebo‐controlled trial, 140 were to combination LOLA, lactulose, rifaximin ( n = 70) or placebo, 70). was given as continuous infusion at dose 30 g over 24 h for 5 days. Ammonia levels, TNF‐α, ILs, endotoxins measured days 0 5. The primary outcome...
Objective Early risk assessment is important in acute pancreatitis (AP). The primary objective of this study was to compare various scores and biochemical markers done on the day admission predicting outcome. Methods Demographic, clinical, laboratory data patients presenting within 2 weeks onset were collected. Various calculated measured admission. Optimum cutoffs identified through receiver operating curve analysis. Multivariate analysis used identify predictors Results Of 343 included,...
Abstract Background and Aim The aim of this study was to analyze etiologies frequency hepatic extrahepatic organ failures (OFs) outcome acute‐on‐chronic liver failure (ACLF) at 10 tertiary centers in India. Methods In retrospective (2011–2014), patients satisfying Asian Pacific Association for the Study Liver definition ACLF were included. Etiology acute precipitating insult chronic disease outcomes assessed. Occurrence severity OF assessed by failure‐sequential assessment score. Results...
Intestinal permeability (IP) has been shown to be increased in acute pancreatitis (AP) and is considered responsible for development of septic complications. However, the mechanism increase IP not well studied. We studied whether alteration tight junction proteins (TJP) any role altered patients with AP.This a prospective study conducted at tertiary care referral center. Twenty consecutive moderate severe AP fulfilling criteria were included along 20 controls that underwent...
Introduction and aim. Multiple prognostic scores are available for acute liver failure (ALF). Our objective was to compare the dynamicity of model end stage disease (MELD), MELD-sodium, early dynamic (ALFED), chronic (CLIF)-consortium ACLF score King’s College Hospital Criteria (KCH) predicting outcome in ALF. Materials methods. All consecutive patients with ALF at a tertiary care centre India were included. MELD, MELD-Na, ALFED, CLIF-C KCH criteria calculated admission day 3 admission. Area...
Severe acute pancreatitis (AP) is associated with high mortality due to systemic inflammatory response syndrome in the early phase and secondary infection later phase. Concomitant intestinal ischemia often results gut injury. We studied fatty acid binding protein (IFABP) citrulline levels as markers of injury predict prognosis AP.Acute patients at admission controls were studied. Serum IFABP was measured by enzyme-linked immunosorbent assay plasma high-performance liquid chromatography...
Objective: Infections are common and associated with complications mortality in acute liver failure (ALF). The temporal relationship between ammonia infection ALF patients is unclear. We aimed to evaluate the predictors of its arterial levels.Materials methods: Consecutive hospitalized January 2004 December 2015, without signs at/within 48 h admission, were included. Occurrence after was documented levels estimated for five consecutive days. Multivariate logistic regression analysis used...
Overt hepatic encephalopathy (OHE) has high risk of recurrence and is associated with poor survival. The role nutrition therapy well documented in cirrhosis, but its efficacy preventing the OHE not been studied.In double blind RCT, we randomly assigned 150 patients liver history recent past to receive (group I) or no II) followed up for 6 months. primary end points were occurrence breakthrough episodes time episode OHE. Secondary related hospitalizations hospitalization involving Other...
Background/Aims: The severe acute respiratory syndrome coronavirus 2 pandemic has affected the gastrointestinal (GI) endoscopy units globally owing to risk of transmission. We present our data on use rapid antigen test (RAT) as a screening tool prior prevent transmission disease (COVID-19).Methods: This study was retrospective analysis patients who underwent any GI endoscopic procedure from July 2020 October at tertiary referral center in New Delhi, India. All for COVID-19 using RAT, and...
Primary mediastinal desmoplastic small round cell cancer is an uncommon tumour usually located in the abdomen and pelvis. Here authors report extremely rare case of a young male with primary anterior middle mediastinum. The patient had non-specific complaints but abnormal shadow was seen routine chest x-ray. He diagnosed as having mass few lung parenchymal deposits on CT. Mediastinoscopy guided biopsy revealed tumour. Desmoplastic aggressive which rarely involves mediastinum site. nature...
Systemic inflammation and organ dysfunction/failure can complicate acute decompensation (AD) of cirrhosis with progression to acute-on-chronic liver failure (ACLF), leading increased mortality. There are few studies on serum biomarkers predicting renal dysfunction (RD) or ACLF in AD. Serum cystatin C (CysC) interleukin-6 (IL-6) were evaluated for RD, ACLF, mortality AD patients.Consecutive patients seen from January 2018 June 2019 included. IL-6 CysC measured at the time index presentation....
Patients with small bowel strictures have varied etiologies, including malignancy. Little data are available on the demographic profiles and etiologies of in patients who undergo surgery because intestinal obstruction but do not a definitive pre-operative diagnosis.Retrospective were analyzed for all operated between January 2000 October 2014 without mass lesions definite diagnosis after imaging endoscopic examinations. Demographic parameters, imaging, endoscopic, histological extracted from...
Background and objectives Studies on the natural history of asymptomatic walled-off necrosis (WON) in acute pancreatitis (AP) are scarce. We conducted a prospective observational study to look for incidence infection WON. Material methods In this study, we included 30 consecutive AP patients with Their baseline clinical, laboratory, radiological parameters were recorded followed up three months. Mann Whitney U test unpaired t-tests used quantitative data chi-square Fisher’s exact tests...
Background The European organization Research and Treatment of Cancer Quality Life Questionnaire-Oesophagogastric 25 (EORTC QLQ-OG 25) is designed for patients with esophagogastric cancer. Its performance has never been tested benign disorders. A health-related quality-of-life questionnaire does not exist corrosive-induced esophageal strictures. Hence, we evaluated the EORTC in Indian corrosive Methods English or Hindi version was administered to 31 adult undergoing outpatient dilation at GB...
Abstract Background and Aim Minimal hepatic encephalopathy (MHE) reflects cognitive impairment in patients with liver cirrhosis is associated poor prognosis. We assessed the effects of nutritional therapy on functions, health‐related quality life (HRQOL), anthropometry, endotoxins, inflammatory markers cirrhotic MHE. Methods In a double‐blind randomized controlled trial, MHE were to (group I: 30–35 kcal/kg/day 1.0–1.5 g protein/kg/day) no II: diet as taking before) for 6 months. was...
Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, has been associated with malignancy, autoimmune disease and collagen vascular disease. The association of infective endocarditis syndrome is rare. authors report a case in patient endocarditis. Infective should be excluded patients rheumatic heart presenting syndrome. Alternatively, considered differential diagnosis when develops skin lesions.
Abstract Introduction The coronavirus disease 2019 (COVID-19) pandemic has affected the healthcare system. residents who are at frontline of this have suffered most. extent training loss due to COVID-19 on gastroenterology (GE) is not studied in India. Methods We designed a 36-question based google survey and distributed it GE all across India, via email. All responses collected were analyzed using appropriate statistical methods. Results A total 140 received. No significant decrease...
Introduction Wire-guided bougienage of the upper esophageal sphincter (UES) was performed routinely before per-oral motorized power spiral enteroscopy (MSE). In present study, we aimed to answer clinical question whether routine UES is required. Methods This a retrospective study that included 20 patients who underwent antegrade for various indications. The feasibility and safety anterograde MSE without prior bougie dilatation were assessed. technical success rate (TSR), diagnostic yield,...