A5070137704- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Congenital heart defects research
- Cellular transport and secretion
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Atherosclerosis and Cardiovascular Diseases
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Inflammatory Biomarkers in Disease Prognosis
- Color Science and Applications
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Neutropenia and Cancer Infections
- Pancreatic function and diabetes
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Structural Characterization
- Kruppel-like factors research
University of Science and Technology Bannu
2020-2025
The University of Texas Southwestern Medical Center
2015-2024
Quaid-i-Azam University
2024
Southwestern Medical Center
2015-2021
Bombay College of Pharmacy
2021
Beijing University of Chemical Technology
2020
Institute of Structural and Molecular Biology
2018
University College London
2018
Dr. M.G.R. Educational and Research Institute
2018
Texas A&M University
2011
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular heterogeneity, we longitudinally profiled the blood transcriptome 158 pediatric patients. Using mixed models accounting for repeated measurements, demographics, treatment, activity (DA), nephritis class, confirmed a prevalent IFN signature identified plasmablast as most robust biomarker DA. We detected gradual...
To study the effects in systemic lupus erythaematosus (SLE) of B cell directed therapy with rituximab, a chimeric monoclonal antibody at CD20+ cells, without concomitant immunosuppressive mild to moderate SLE.Patients (n=24) active SLE and failure >or=1 were recruited from three university centres into this phase I/II prospective open-label study. Patients followed for 1 year assess safety, efficacy biological effects.In total, 18 patients scheduled receive full lymphoma dose rituximab...
Up to 40% of cancer patients on immune checkpoint inhibitors develop clinically significant immune-related adverse events (irAEs). The role host status and function in predisposing the development irAEs remains unknown.Sera from 65 receiving 13 healthy controls were evaluated for 40 cytokines at pre-treatment, after 2-3 weeks 6 analysed correlation with irAEs.Of enrolled, 55% women; mean age was years 98% received anti-PD1/PDL1 therapy. occurred 35% cases. Among controls, cytokine levels...
Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls produced a comprehensive dataset the variations causing susceptibility to systemic lupus erythematosus (SLE). Two independent disease association signals in HLA-D region identified two regulatory regions containing 3562 polymorphisms that modified thirty-seven transcription factor binding sites. These extensive functional are new potent facet HLA polymorphism. Variations modifying consensus motifs IRF4 CTCF...
Abstract 3-Methylcholanthrene (3MC) is an aryl hydrocarbon receptor (AhR) agonist, and it has been reported that 3MC induces estrogenic activity through AhR-estrogen α (ERα) interactions. In this study, we used 3,3′,4,4′,5-pentachlorobiphenyl (PCB) as prototypical AhR ligands, both compounds activated estrogen-responsive reporter genes/gene products (cathepsin D) in MCF-7 breast cancer cells. The responses induced by these ligands were inhibited the antiestrogen ICI 182780 transfection of a...
Correction for ‘White light emission and superior color stability in a single-component host with exceptional eminent rendering theoretical calculations on D uv quality’ by Wasim Ullah Khan et al. , Mater. Adv. 2024, 5 9851–9861, https://doi.org/10.1039/D4MA00937A.
Researchers investigate the relationship between social media activities and civic involvement in today's digital environment by using mediation-moderation analytical approaches. Today's platforms Facebook Twitter Instagram deliver transformative communication tools that support participation empowering voting supporting volunteering advocacy endeavors. Users connect emotionally on which translates into through Online Political Efficacy as mediating factor. Digital literacy functions a...
We report on 2 patients with compound heterozygous mutations in forkhead box N1 (FOXN1), a transcription factor essential for thymic epithelial cell (TEC) differentiation. TECs are critical T development. Both had presentation consistent T–/loB+NK+ SCID, normal hair and nails, distinct from the classic nude/SCID phenotype individuals autosomal-recessive FOXN1 mutations. To understand basis of this effects FOXN1, we generated mice using CRISPR-Cas9 technology to genocopy 1 patients. The Foxn1...
Background Increased body mass index (BMI) has been associated with improved response to immune checkpoint inhibitors (ICIs) in multiple cancer types. We evaluated associations between BMI, ICI dosing strategy, and clinical outcomes. Methods abstracted data on patients treated ICI, including age, sex, type, strategy (weight-based or fixed), radiographic response, overall survival (OS), progression-free (PFS). compared outcomes low-BMI high-BMI populations using Kaplan-Meier curves, Cox...
Antibiotic administration is associated with worse clinical outcomes and changes to the gut microbiome in cancer patients receiving immune checkpoint inhibitors (ICI). However, effects of antibiotics on systemic function are unknown. We, therefore, evaluated antibiotic exposure, therapeutic responses, multiplex panels 40 serum cytokines 124 antibodies at baseline six weeks after ICI initiation, p < 0.05 false discovery rate (FDR) 0.2 considered significant. A total 251 were included, whom...
Abstract Immune checkpoint inhibitor (ICI)-induced immune-related adverse events (irAEs) may affect almost any organ system and occur at point during therapy. Autoantibody analysis provide insight into the mechanism, nature, timing of these events. We report a case ICI-induced late-onset Raynaud's-like phenomenon in patient receiving combination immunotherapy. A 53-year-old woman with advanced non-small lung cancer received anti-cytotoxic T-lymphocyte antigen 4 anti-programmed death 1 ICI...
Although significant progress has been achieved in elucidating the genetic architecture of systemic lupus erythematosus (SLE), identifying genes underlying pathogenesis challenging. The NZM2410-derived susceptibility Sle3 locus is associated with T cell hyperactivity and activated myeloid cells. However, candidate these phenotypes have not identified. Here, we narrow to a smaller genomic segment (Sle3k) show that mice carrying Sle3k Sle1 loci developed nephritis. We identify Klf13 as primary...
Eu 3+ plays a key role in enhancing the R of single-phase white-light-emitting phosphors, which exhibit excellent thermal stability (I@400 K∼93%). A WLED with an 89.9 was fabricated, featuring D uv ±0.002 to ±0.014, meeting ANSI standards.
Immune-related adverse events induced by immune checkpoint inhibitor (ICI) therapy may affect diverse organ systems, including skeletal and cardiac muscle. ICI-associated myositis result in substantial morbidity occasional mortality. We present a case of patient with advanced non-small cell lung cancer who developed grade 4 concurrent myocarditis early after initiation anti-programmed death ligand 1 (durvalumab). Autoantibody analysis revealed marked increases...
Article11 December 2015Open Access Source Data A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression Benjamin B Shields Departments of Cell Biology, University Texas Southwestern Medical Center, Dallas, TX, USA Search for more papers by this author Chad V Pecot Center RNA interference and Non-Coding RNA, MD Anderson Cancer Houston, Hua Gao Elizabeth McMillan Malia Potts Christa Nagel Obstetrics Gynecology, Scott Purinton Ying Wang Department...
Background Immune checkpoint inhibitor (ICI) therapies may cause unpredictable and potentially severe autoimmune toxicities termed immune-related adverse events (irAEs). Because T cells mediate ICI effects, cell profiling provide insight into the risk of irAEs. Here we evaluate a novel metric—the T-cell tolerant fraction—as predictor future Methods We examined receptor beta (TRB) locus sequencing from baseline pretreatment samples an institutional registry previously published studies. For...