A5084039025- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Immune cells in cancer
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Cancer, Stress, Anesthesia, and Immune Response
- Ferroptosis and cancer prognosis
- Estrogen and related hormone effects
- Vitamin D Research Studies
- Cardiac Valve Diseases and Treatments
- Advancements in Battery Materials
- S100 Proteins and Annexins
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Bacteriophages and microbial interactions
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Chemical Synthesis and Characterization
- Sex and Gender in Healthcare
- Occupational health in dentistry
Jackson Laboratory
2017-2023
Tulane University
2021-2022
National Cheng Kung University
2013-2021
Leiden University Medical Center
2021
Laboratoire de Chimie
2021
Immunai (United States)
2021
National University of Kaohsiung
2020
Mackay Medical College
2020
Baylor University
2017-2018
Idaho State University
2017
Differences in immune function and responses contribute to health- life-span disparities between sexes. However, the role of sex system aging is not well understood. Here, we characterize peripheral blood mononuclear cells from 172 healthy adults 22-93 years age using ATAC-seq, RNA-seq, flow cytometry. These data reveal a shared epigenomic signature including declining naïve T cell increasing monocyte cytotoxic functions. changes are greater magnitude men accompanied by male-specific decline...
Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel the regulatory programs behind these changes, we applied systems immunology approaches profiled chromatin accessibility transcriptome PBMCs purified monocytes, B cells, T cells. Analysis of samples from 77 young elderly donors revealed a novel robust aging signature PBMCs, with simultaneous systematic closing at promoters enhancers associated cell signaling potentially stochastic opening...
Diverse mouse strains have different health and life spans, mimicking the diversity among humans. To capture conserved aging signatures, we studied long-lived C57BL/6J short-lived NZO/HILtJ by profiling transcriptomes epigenomes of immune cells from peripheral blood spleen young old mice. Transcriptional activation AP-1 transcription factor complex, particularly Fos, Junb, Jun genes, was most significant signature across tissues strains. ATAC-seq data analyses showed that chromatin around...
Abstract Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease originates from tumor-infiltrating CD11c+ myeloid cells. triggered by cell membrane–derived TGFβ. Neutralizing TGFβ or IL1 receptor prevents progression humanized mouse model. Patients metastatic HER2− display a transcriptional signature inflammation the blood leukocytes, which attenuated after blockade. When...
Rice (Oryza sativa) is one of the world's most important crops. researchers make extensive use insertional mutants for study gene function. Approximately half a million flanking sequence tags from rice mutant libraries are publicly available. However, relationship between genotype and phenotype very weak. Transgenic plant assays have been used frequently complementation, overexpression or antisense analysis, but changes caused by callus growth, Agrobacterium incubation medium, virulence...
Hierarchical micro/mesoporous carbons were prepared using ZnO nanoparticles as hard templates and a petroleum industrial-residual pitch the carbon source via solvent-free process. The can be easily removed HCl(aq), thereby avoiding limitations present in conventional porous silica templating approaches that require highly corrosive HF(aq) for template removal. Notably, proposed synthetic method from low-cost to high-value is friendly process with respect our overexploited environment. With...
Antrodia cinnamomea, a well-known traditional medicine used in Taiwan, is potent anticancer drug for colorectal cancer, but the upstream molecular mechanism of its effects remains unclear. In this study, A. cinnamomea extracts showed cytotoxicity HCT116, HT29, SW480, Caco-2 and, Colo205 cancer cells. Whole-genome expression profiling HCT116 cells was performed. upregulated endoplasmic reticulum stress marker CHOP and downstream gene TRB3. Moreover, dephosphorylation Akt mTOR as well...
Using genome-wide approaches, we studied the microRNA (miRNA) expression profile during human plasma cell (PC) differentiation induced by stimulation of blood B cells with T follicular helper cell-dependent signals. Combining profiles differentially expressed genes in PC gene ontology (GO) analysis revealed that a significant group involved transcription factor (TF) activity was preferentially changed. We thus focused on studying effects miRNAs several key TFs differentiation. Cohorts...
Abstract Differences in immune function and responses contribute to health- life-span disparities between sexes. However, the role of sex system aging is not well understood. Here, we characterize peripheral blood mononuclear cells from 172 healthy adults 22-93 years age using ATAC-seq, RNA-seq, flow-cytometry. These data reveal a shared epigenomic signature including declining naïve T cell increasing monocyte/cytotoxic functions. changes were greater magnitude men accompanied by...
Most tailed bacteriophages (phages) feature linear dsDNA genomes. Characterizing novel phages requires an understanding of complete genome sequences, including the definition physical ends. We sequenced 48 Bacillus cereus phage isolates and analyzed Next-generation sequencing (NGS) data to resolve configuration these phages. assembled contigs featured reads that mapped both contig ends formed circularized contigs. Independent assemblies 31 nearly identical I48-like allowed us observe...
In this work, we present the extension of an alternative subtraction scheme for next-to-leading order QCD calculations to case arbitrary number massless final state partons. The is based on splitting kernels improved parton shower and comes with a reduced momentum mappings. While previous publication including setup has been restricted cases maximally two partons in state, here provide real emission integrated terms processes any We apply our three jet production at lepton colliders results...
Intelligent building automation systems require a large number of sensors to increase spatial resolution in order achieve fine-grained sensing and control. However, traditional are wired networks that tremendous cabling cost. In addition, cables themselves unwelcome many living environments. ZigBee has become an emerging wireless networking technology recent years, which meets easy installation flexible deployment requirements. Also, satisfies the market's need for cost-effective,...
Abstract— It is generally accepted that bacteria in or outside the root canal are reason for apical periodontitis and endodontic failures. This case report presents a 60‐year‐old woman with periapical lesion fistulous tract which did not respond to conventional treatment. During surgery, granulomatous tissue was removed calculus‐like deposit observed on surface. A radicular cyst diagnosed. Nine months after this had been enucleated, complete recovery of bone occurred. suggested presence at...
Multiporous carbons (MPCs) are prepared using ZnO as a hard template and biomass pyrolysis oil the carbon source. It is shown that surface area, pore volume, mesopore/micropore ratio of as-prepared MPCs can be easily controlled by adjusting ZnO/oil ratio. Sulfur/MPC (S/MPC) composite blending sulfur powder with followed microwave heating at three different powers (100 W/200 W/300 W) for 60 s. The unique micro/mesostructure characteristics resulting porous not only endow S/MPC sufficient...
Introduction Transcatheter aortic valve replacement (TAVR) has become a leading treatment for patients with severe stenosis (AS). Recent studies comparing TAVR outcomes balloon-expandable valves (BEVs) and self-expandable (SEVs) show generally similar results, although BEVs have lower rates of moderate-to-severe regurgitation pacemaker implantation. This study aimed to compare the clinical SEVs in Taiwan. Methods The Taiwan National Health Insurance Research Database (NHIRD) is...
ABSTRACT Diverse mouse strains have different health and life spans, mimicking the diversity among humans. To capture conserved aging signatures, we studied long-lived C57BL/6J short-lived NZO/HILtJ by profiling transcriptomes epigenomes of immune cells from peripheral blood spleen young old mice. Transcriptional activation AP-1 transcription factor complex, particularly Fos, Junb , Jun genes, was most significant signature across tissues strains. ATAC-seq data analyses showed that chromatin...
Background: The purpose of this study is to investigate the prevalence neck and low back discomfort its association with intervertebral angulations cervical lumbar during neutral flexion among aircrews. Methods: There were 283 subjects participating in survey. All participants finished one questionnaire each regarding complaints about musculoskeletal symptoms, three sagittal plane radiographs. measurements completed using Cobb method for spine Harrison posterior tangent spine. Results: In...
We present an alternative subtraction scheme for the treatment of infrared divergences in NLO QCD calculations. In this scheme, number transformations is greatly reduced with respect to standard by Catani and Seymour. discuss general setup as well first applications processes at hadron lepton colliders.
We present a model of the charge transport in thin film organic field-effect transistors with active channel made linear conjugated chains stacked on substrate end-on-orientation. The was simulated box consisting 25 polymer chains, which delocalized quantum orbital eigenstates on-chain hole distribution were calculated. inter-chain transfer solved semi-classically. full self-consistent density and electric field determined for various applied gate source-drain voltages. found that dependence...