A5002027441- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
- Cardiovascular Function and Risk Factors
- Liver Disease and Transplantation
- Congenital heart defects research
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Cardiovascular and Diving-Related Complications
- Cardiac pacing and defibrillation studies
- Vascular anomalies and interventions
- Heart Failure Treatment and Management
- Aortic Disease and Treatment Approaches
- Eosinophilic Disorders and Syndromes
- Vascular Anomalies and Treatments
- Neurological disorders and treatments
- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Body Composition Measurement Techniques
- Renal and Vascular Pathologies
- Advanced MRI Techniques and Applications
Tokyo Women's Medical University
2016-2025
Tokyo Women's Medical University Hospital
2015-2021
St. Luke's International Hospital
2013-2021
Seirei Hamamatsu General Hospital
2021
Family Court of Australia
2016-2018
Advisory Board Company (United States)
2017-2018
Shimizu (Japan)
2017-2018
Keiai University
2012-2016
Japan Pediatric Society
2013
Biologie des maladies cardiovasculaires
2013
Background: Mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene, activin receptor-like kinase 1 (ALK1) and SMAD8 gene have been reported heritable pulmonary arterial hypertension (HPAH) idiopathic (IPAH). However, almost 30% of HPAH cases 60-90% IPAH no mutations those genes. This suggests that there remain unidentified genes associated with IPAH. Methods Results: study screened for endoglin, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, 1A (BMPR1A) 1B (BMPR1B) 43...
Objective Fontan-associated liver disease (FALD) is widely recognised as a common complication in patients long after the Fontan operation. However, data on predictors of FALD that can guide its screening and management are lacking. The present study aimed to identify cirrhosis (LC) hepatocellular carcinoma (HCC) post-Fontan patients. Methods This was multi-institutional retrospective cohort study. Clinical all perioperative survivors operation before 2011 who underwent postoperative...
Background:Red cell distribution width (RDW) is known to be associated with anemia and mortality in cardiovascular diseases, while itself related increased mortality. RDW may also cytokine activation. We investigated the potential of predict anemia-adjusted patients adult congenital heart disease (ACHD) we evaluated relationships among RDW, anemia, interleukin-6 (IL-6).Methods Results:This was a single-center, retrospective cohort study. Blood IL-6 levels were measured 144 ACHD (median age...
Abstract Mutations of BMPR2 and other TGF ‐ β superfamily genes have been reported in pulmonary arterial hypertension ( PAH ). However, 60–90% idiopathic cases no mutations these genes. Recently, the expression NOTCH3 was shown to be increased artery smooth muscle cells patients. We sought investigate its target patients clarify role signaling. screened for , HES1 HES5 41 who had ALK1 endoglin SMAD1/4/8 BMPR1B or Caveolin‐1 . Two novel missense (c.2519 G>A p.G840E, c.2698 A>C p.T900P)...
The incidence of hepatocellular carcinoma (HCC) in patients with Fontan-associated liver disease (i.e., FALD-HCC) has increased over time. However, the risk factors for HCC development remain unclear. Here, we compared levels non-invasive markers to survival rate FALD-HCC patients.From 2003 2021, 154 (66 men, 42.9%) developed after undergoing Fontan procedures. was diagnosed 15 (9.7%) (8 53.3%) at a median age 34 years (range, 21-45 years). We and non-HCC cases; generated marker level...
α/β- and β-blockers are essential in pregnant women's perinatal congenital heart disease management. Nevertheless, data on the effects of women fetuses limited. We examined risks neonatal hypoglycemia small for gestational age (SGA) associated with maternal exposure to β-blockers.
Background: Some potential biomarkers have been reported recently in patients with pulmonary arterial hypertension (PAH), but the most clinically useful among these biomarkers, especially childhood PAH, has not identified. Therefore, this study investigated which biomarker is assessing severity of and patient prognosis idiopathic PAH (IPAH)/heritable (HPAH). Methods Results: Fifty-nine who were younger than 16 years at onset IPAH/HPAH selected. The following 10 candidates quantified:...
Although amiodarone (AMD)-induced thyroid dysfunction (AITD) is an important complication of AMD therapy, little known about AITD in adult Japanese patients with congenital heart disease (CHD).We retrospectively studied 131 CHD who were on low-dose (median, 150 mg/day). The median patient age was 28 years, and the follow-up 44 months. incidence, clinical course, risk factors AITD, including AMD-induced thyrotoxicosis (AIT) hypothyroidism (AIH), evaluated. total incidence 30% (AIT: 18%, n=24;...
Abstract Noonan syndrome (NS) is the most common non‐chromosomal seen in children and characterized by short stature, dysmorphic facial features, chest deformity, a wide range of congenital heart defects developmental delay variable degree. Mutations Ras/mitogen‐activated protein kinase (MAPK) signaling pathways cause about 70% NS cases with KRAS mutation present 2%. In cohort 65 clinically confirmed patients Japanese origin, we screened for mutations RAS genes direct sequencing. We found...
Background: Although the survival rate for repaired Tetralogy of Fallot (TOF) is dramatically improving, anatomical and functional residua sequelae followed by arrhythmias sudden death are still challenging issues to be resolved. Reoperation can reduce incidence death, but there no consensus on indications reoperation patients with TOF, especially in Japan. Methods Results: A cross-sectional questionnaire survey TOF was performed through a Japanese multicenter study. The questionnaire, which...
This study aimed to analyze long-term survival and functional outcomes after truncus arteriosus repair in a single institution with more than 40 years of follow-up.Medical records were analyzed retrospectively 52 patients who underwent the Rastelli procedure for between 1974 2002. Thirty-five survived initial repair. The median age at operation was 2.8 months (range, 0.1-123 months) body weight 3.9 kg 1.6 15.0 kg).The follow-up 23.6 12.4 44.5 years). duration 23.4 12.3 40.7 actuarial rate...