A5101766959- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- RNA modifications and cancer
- TGF-β signaling in diseases
- Congenital heart defects research
- ATP Synthase and ATPases Research
- Click Chemistry and Applications
- Connective tissue disorders research
- Muscle Physiology and Disorders
- SARS-CoV-2 and COVID-19 Research
- Fibroblast Growth Factor Research
- Protein Tyrosine Phosphatases
- Virology and Viral Diseases
- Tissue Engineering and Regenerative Medicine
- Diverse Scientific Research Studies
- Teratomas and Epidermoid Cysts
- Protein Degradation and Inhibitors
- Computational Drug Discovery Methods
Nanjing Medical University
2018-2024
Nanjing University
2018-2024
Second Affiliated Hospital of Nanchang University
2020-2024
Nanchang University
2020-2023
Jining First People's Hospital
2019
Baylor College of Medicine
2017
Baylor Genetics
2016
University of Utah
2006-2012
Mitogen-activated protein kinase (MAPK) pathways are major mediators of extracellular signals that transduced to the nucleus. MAPK signaling is attenuated at several levels, and one class dual-specificity phosphatases,the phosphatases (MKPs), inhibit by dephosphorylating activated MAPKs. Several MKPs themselves induced they regulate, forming negative feedback loops attenuate signals. We show here in mouse embryos, Fibroblast growth factor receptors (FGFRs) required for transcription Dusp6,...
Glucocorticoid (GC) induced osteoporosis (GIO) is caused by the long-term use of GC for treatment autoimmune and inflammatory diseases. The related disruption bone marrow microcirculation increased adipogenesis contribute to GIO development. However, neither currently available anti-osteoporosis agent completely addressed adipogenesis. Salvianolic acid B (Sal B) a polyphenolic compound from Chinese herbal medicine, Salvia miltiorrhiza Bunge. aim this study was determine effects Sal on...
Abstract While the epidermal growth factor receptor (EGFR)–mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions development homeostasis of skeletal system poorly defined. To address vivo role, we constructed transgenic pharmacologic mouse models used peripheral quantitative computed tomography (pQCT), micro–computed (µCT) histomorphometry analyze their trabecular cortical bone phenotypes. We initially deleted EGFR...
The current study aimed to explore the role of tumor-derived extracellular vesicles (EVs) in angiogenesis during nasopharyngeal carcinoma (NPC). NPC biopsy specimens were initially collected. Human umbilical vein endothelial cells (HUVECs) co-cultured with EVs isolated from cells, after which their migration, invasion, as well vessel-like tube formation evaluated by Transwell chamber systems and Matrigel-based assays. pro-angiogenic activities candidate microRNA (miRNA or miR) examined using...
The PML (promyelocytic leukaemia) protein, also known as TRIM19, functions a major organizer of nuclear bodies (NBs) in most mammalian cells and plays important roles antiviral activities against both DNA RNA viruses. In the current study, we found that downregulation rendered HeLa more susceptible to infection by enterovirus 71, overexpression PMLIII or PMLIV isoforms inhibited viral protein expression resulted titres were 2 3 log units lower than control. Using short interfering RNAs,...
Mutations in FBXL4 have recently been recognized to cause a mitochondrial disorder, with clinical features including early onset lactic acidosis, hypotonia, and developmental delay. sequence analysis was performed 808 subjects suspected disorder. In addition, 28 samples from patients of but without identifiable mutations 192 genes known diseases, were examined for mutations. Definitive diagnosis made 10 new total 7 novel deleterious variants; 5 null 2 missense substitutions. All exhibited...
Long non-coding RNA (lncRNA) has been proposed to regulate tumorigenesis, however, the role of small nucleolar host gene 8 (SNHG8) in nasopharyngeal carcinoma (NPC) remains unclear. Levels SNHG8 NPC tissues and cells were analyzed with real‐time quantitative PCR method. Cell counting kit-8 assay, colony formation wound-healing transwell invasion assay performed detect cell viability, migration, invasion. Luciferase activity RIP explore relationships among SNHG8, microRNA-656−3p (miR-656−3p),...
Background and Objective: COVID-19 has struck our society as a great calamity, the need for effective anti-viral drugs is more urgent than ever. Papain-like protease (PLpro) of SARS CoV-2 plays important roles in virus maturation, dysregulation host inflammation, antiviral immune responses, which being regarded promising druggable target treatment COVID-19. Here, we carried out combined screening approach to identify novel highly potent PLpro inhibitors Methods: We used structure-based...
Age-related hearing loss (ARHL) is the most common cause of in elderly. Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) a deubiquitinating enzyme involved several types human disease. The present study aimed to investigate effect UCHL1 on hydrogen peroxide (H2O2)-induced ARHL model cochlear hair cells and uncover its underlying mechanism. Reverse transcription-quantitative (RT-q)PCR western blot analysis were used assess expression HEI-OC1 exposed H2O2. Following overexpression H2O2-induced...
Abstract Lymphoma is a common cause of cancer worldwide with an increasing incidence in recent years. A large number studies have shown that HOX transcript antisense intergenic RNA (HOTAIR) exerts as oncogene various neoplasms. However, the function HOTAIR lymphoma still remains unclear. The present study aimed to investigate and its underlying mechanisms. expressions HOTAIR, miR‐148b, BMI1 samples cells (AHH‐1, Raji, U937) were quantified by quantitative reverse polymerase chain reaction...
Histone deacetylases (HDACs) are key enzymes in epigenetics and promising targets for anticancer therapy. Although several drugs targeting HDAC have been approved the treatment of tumors, their clinical use has limited by deleterious side effects poor efficacy. Herein, we discover four potent inhibitors through pharmacophore model screening molecular docking. These compounds able to bind HDACs 1, 3, 6 with nanomolar affinity. Among them, compound 3 shows greater inhibitory effect on than...
Allergic rhinitis (AR) is an allergic disease of nasal mucosa. LncRNAs are key modulators affecting AR development. Neverthelss, the impact lncRNA ANRIL in not clear.This work decided to study mechanism underlying on TLR4 expression through targeting miR-16-5p during autophagy and epithelial barrier dysfunction progression AR.Human cells were exposed TNF-α establish cell model, mice model was constructed by ovalbumin (OVA) treatment. QRT-PCR or western blot assays applied measure levels mRNA...
Zika virus (ZIKV) primarily spreads through mosquito bites and can lead to microcephaly in infants Guillain-Barre syndrome adults. It is noteworthy that ZIKV persist the semen of infected males for extended periods be sexually transmitted. Infection with has severe pathological manifestations on testicular tissues male mice, resulting reduced sperm motility fertility. However, there are no approved prophylactic vaccines or therapeutics available treat infection. Using a type I II interferon...
A clinical case of ectopic thyroid carcinoma in front hyoid bone was reported this paper. The patient, a 17-year-old female, presented with an enlarging neck mass 1-week history. Physical examination revealed 3 cm×2 cm the bone. Ultrasonographic depicted as cystic solid mixed echogenic punctate strong echogenicity. CT scan showed cystic-solid calcifications. patient misdiagnosed thyroglossal duct cyst and underwent surgery. final pathological diagnosis papillary...
Objective Previous studies determined ovariectomy (OVX) induced cancellous bone loss and raised cage (RC) bipedal stance partially prevented OVX at red marrow sites in adult rats; however, these effects the distal tibial metaphysis (DTM) with fatty marrow, a site similar to long metaphyses (non‐veterbral sites) low risk of postmenopausal fracture, have yet be determined. Methods Six‐month‐old female S‐D rats were divided into basal, sham, OVX, RC combination plus exercise for 4 8 weeks,...