Zhang Zhong-fu

ORCID: 0000-0003-0334-1268
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About
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Research Areas
  • Graph Labeling and Dimension Problems
  • Advanced Graph Theory Research
  • graph theory and CDMA systems
  • Graph theory and applications
  • Limits and Structures in Graph Theory
  • Vehicle Dynamics and Control Systems
  • Mechanical Engineering and Vibrations Research
  • Geological and Geophysical Studies
  • Industrial Technology and Control Systems
  • Smart Agriculture and AI
  • earthquake and tectonic studies
  • Cancer-related molecular mechanisms research
  • Spectroscopy and Chemometric Analyses
  • Electric and Hybrid Vehicle Technologies
  • MicroRNA in disease regulation
  • Advanced Mathematical Theories
  • Nuclear Receptors and Signaling
  • Microbial Community Ecology and Physiology
  • Computational Geometry and Mesh Generation
  • Advanced Sensor and Control Systems
  • Bladder and Urothelial Cancer Treatments
  • Circular RNAs in diseases
  • Geophysics and Gravity Measurements
  • Aquaculture disease management and microbiota
  • Cardiovascular Health and Risk Factors

Shenzhen Second People's Hospital
2014-2025

Shanghai University of Traditional Chinese Medicine
2024

National Taiwan Ocean University
2023-2024

Institute of Information Science, Academia Sinica
2024

Academia Sinica
2024

Hospital of Hebei Province
2024

Southwest Forestry University
2020-2023

Huazhong Agricultural University
2021-2023

Yunnan Academy of Agricultural Sciences
2023

Yunnan Institute of Tropical Crops
2023

With the advent of second-generation sequencing, expression gene transcripts can be digitally measured with high accuracy. The purpose this study was to systematically profile both mRNA and miRNA genes in clear cell renal carcinoma (ccRCC) using massively parallel sequencing technology.The mRNAs miRNAs were analyzed tumor tissues matched normal adjacent obtained from 10 ccRCC patients without distant metastases. In a prevalence screen, some most interesting results validated large cohort...

10.1371/journal.pone.0015224 article EN cc-by PLoS ONE 2010-12-30

Background MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They aberrantly expressed in many types cancers. In this study, we determined the genome-wide miRNA profiles bladder urothelial carcinoma by deep sequencing. Methodology/Principal Findings We detected 656 differentially known human miRNAs and antisense sequences (miRNA*s) nine patients Many miRNA*s were significantly upregulated or downregulated compared to matched histologically normal...

10.1371/journal.pone.0018286 article EN cc-by PLoS ONE 2011-03-28

10.1016/s0893-9659(02)80015-5 article EN publisher-specific-oa Applied Mathematics Letters 2002-07-01

Abstract Objectives Recent advances in patient‐derived cancer organoids have opened a new avenue for personalised medicine. We aimed to establish an vitro technological platform evaluate chimeric antigen receptor (CAR)‐T cell‐mediated cytotoxicity against bladder cancer. Methods Patient‐derived (BCOs) were derived using classic medium containing R‐spondin 1 and noggin. The features of BCOs characterised via H&E, whole‐exome sequencing immunofluorescence specific markers. Surface...

10.1002/cti2.1248 article EN cc-by-nc-nd Clinical & Translational Immunology 2021-01-01

The current study is to investigate the expression pattern and biological function of long non-coding RNA Focally gastric cancer-associated transcript3 (GACAT3) in bladder cancer. Real-time quantitative qPCR was used detect level GACAT-3 tumor tissues paired normal tissues. Human cancer T24 5637 cell lines were transiently transfected with specific CRISPR-Cas13 or negative control CRISPR-Cas13. Cell migration, proliferation, apoptosis measured by using wound healing assay CCK-8 Caspase-3...

10.3389/fmolb.2020.627774 article EN cc-by Frontiers in Molecular Biosciences 2021-01-18

Abstract Oxidative stress strongly influences the pathophysiology of erectile dysfunction (ED). In this study, we used oxidative balance score (OBS), a composite index, to measure effects triggered by diet and lifestyle factors. Here, conducted cross-sectional study determine statistical relationship between OBS ED among adult males in U.S. The data from 3318 participants National Health Nutrition Examination Survey (NHANES) 2001–2004 were analyzed. Weighted logistic regression was correct...

10.1038/s41598-024-61287-w article EN cc-by Scientific Reports 2024-05-10

Purpose To evaluate the association of Life’s Essential 8 (LE8) and its subscales with male biochemical androgen deficiency (MBAD) total testosterone based on data from national health nutrition examination survey (NHANES) database. Methods Data males aged 20 years or older NHANES 2013–2016 were extracted. LE8 score was calculated American Heart Association definitions. Total (TT) values measured in using precise isotope dilution liquid chromatography. MBAD defined as serum TT <300...

10.3389/fendo.2024.1369684 article EN cc-by Frontiers in Endocrinology 2024-06-24

To reduce the use of antibiotics and chemicals in aquaculture, an edible herb, Bidens pilosa, has been selected as a multifunctional feed additive. Although there considerable research into effects B. pilosa on poultry, wider particularly growth gut microbiota fish, remain largely unexplored. We aimed to investigate interactive between host using transcriptomics pilosa-fed tilapia. In this study, we added 0.5% 1% diet observed that performance tilapia significantly increased over 8 weeks...

10.1186/s12864-024-10674-8 article EN cc-by-nc-nd BMC Genomics 2024-08-13

Long-chain non-coding RNA (LncRNA) has been found to play an important role in the regulation of occurrence and progression renal cell carcinoma (RCC). In this study, we demonstrated that LncRNA NEAT1 expression m6A methylation level was decreased RCC tissues. Further, downregulated associated with poor prognosis for patients. Then used CRIPSR/dCas13b-METTL3 methylate cells. The results showed upregulated after methylated by dCas13b-METTL3 And proliferation migration ability cells NEAT1....

10.3389/fcell.2021.777349 article EN cc-by Frontiers in Cell and Developmental Biology 2021-12-09

Abstract Cereals are the main food for mankind. The grain shape extraction and filled/unfilled recognition meaningful crop breeding genetic analysis. conventional measuring method is mainly manual, which inefficient, labor-intensive subjective. Therefore, a novel was proposed to extract phenotypic traits of cereal grains based on point clouds. First, structured light scanner used obtain cloud data. Then, single segmentation accomplished by image preprocessing, plane fitting, region growth...

10.1038/s41598-022-07221-4 article EN cc-by Scientific Reports 2022-02-24

10.1007/s10255-010-0011-4 article EN Acta Mathematicae Applicatae Sinica English Series 2010-09-03

Verticillium wilt is one of the most critical cotton diseases, which widely distributed in cotton-producing countries. However, conventional method verticillium investigation still manual, has disadvantages subjectivity and low efficiency. In this research, an intelligent vision-based system was proposed to dynamically observe with high accuracy throughput. Firstly, a 3-coordinate motion platform designed movement range 6,100 mm × 950 500 mm, specific control unit adopted achieve accurate...

10.34133/plantphenomics.0013 article EN cc-by Plant Phenomics 2023-01-01

In China, the main sugarcane (Saccharum spp.) planting areas can be found in low-latitude plateau (21° N-25° N, 97° E-106° E), which has most of natural ecological types. However, there is limited information on climate conditions this region and their influence yield sucrose content. Monthly variations factors, namely, average air temperature (AAT), relative humidity (ARH), rainfall amount (ARA), sunshine duration (ASD), from 2000 to 2019 content 26 major sugarcane-producing 2001/2002...

10.3390/plants12142712 article EN cc-by Plants 2023-07-21
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