A5101952816- Ferroelectric and Piezoelectric Materials
- Microwave Dielectric Ceramics Synthesis
- Advanced ceramic materials synthesis
- Extracellular vesicles in disease
- Dielectric properties of ceramics
- MicroRNA in disease regulation
- Perovskite Materials and Applications
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Quantum Dots Synthesis And Properties
- Electrophoretic Deposition in Materials Science
- Advanced Battery Materials and Technologies
- Head and Neck Cancer Studies
- Phagocytosis and Immune Regulation
- Metal and Thin Film Mechanics
- Multiferroics and related materials
- Advancements in Battery Materials
- Immunotherapy and Immune Responses
- Acoustic Wave Resonator Technologies
- Oral Health Pathology and Treatment
- Seed and Plant Biochemistry
- Dielectric materials and actuators
- Phonocardiography and Auscultation Techniques
Wuhan University
2020-2025
University of Shanghai for Science and Technology
2022-2025
Huazhong University of Science and Technology
2012-2024
Wuhan National Laboratory for Optoelectronics
2021-2024
BackgroundThe overall prognosis of oral cancer remains poor because over half patients are diagnosed at advanced-stages. Previously reported screening and earlier detection methods for still largely rely on health workers' clinical experience as yet there is no established method. We aimed to develop a rapid, non-invasive, cost-effective, easy-to-use deep learning approach identifying cavity squamous cell carcinoma (OCSCC) using photographic images.MethodsWe developed an automated algorithm...
Patients with locally advanced oral squamous cell carcinoma (OSCC) have poor outcomes standard care. Neoadjuvant therapy is shown to be effective for these patients. In the randomized, two-arm, phase 2, non-comparative trial, we investigate efficacy and safety of neoadjuvant programmed death 1 (PD-1) inhibitor camrelizumab or without docetaxel-cisplatin-5-fluorouracil (TPF) chemotherapy in patients resectable OSCC. stage III-IVA OSCC receive three cycles (arm Cam) two TPF Cam+TPF), followed...
Abstract Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different pathways as well interaction pattern molecules carried on circulating small extracellular vesicles (sEV) might contribute to the low response rate. Here we demonstrate that PD-1 and CD80 immunocyte-derived sEVs (I-sEV) induce an adaptive redistribution PD-L1 in tumour cells. The resulting decreased cell membrane expression increased sEV secretion into...
Abstract To accurately identify the functions of tumour‐cell‐derived extracellular vesicles (T‐EVs), EVs directly isolated from tumour tissues are much preferred over those derived in vitro cultured cell lines. However, functional analysis T‐EVs has still been severely limited by difficulty selective isolation tissue‐derived heterogeneous EVs, which also contain non‐tumour cell‐derived EVs. We here establish an untouched strategy that specifically collects natural removing...
PD-L1-positive extracellular vesicles (PD-L1
Three novel CCK secretion-stimulating peptides were successfully identified from barley protein hydrolysate. Peptide VVTGVGGQ could activate CaSR-Gq-Ca 2+ signaling to stimulate the transcription of gene and secretion CCK.
Cholecystokinin (CCK), secreted by enteroendocrine cells, plays a vital role in suppressing appetite. This study aimed to evaluate the vivo effect of oat protein hydrolysate (OPH) on CCK secretion and elucidate structural characteristics responsible peptides their underlying mechanism action. OPH was prepared simulated gastrointestinal digestion model. Intragastric administration mice significantly increased plasma levels. Using size exclusion column chromatography liquid...
An artificial visual system is developed based on ZnO TS neurons, featuring excellent device performance and stable neuron circuit operation. The utilizes rate-time fusion coding strategies to enable efficient accurate recognition.
The demand for plant-based proteins has been rapidly increasing due to sustainability, ethical and health reasons. present study aimed investigate the digestion characteristics of three plant (quinoa, barley mungbean) based on an in vitro model effect their simulated gastrointestinal digests satiety hormone cholecystokinin (CCK) secretion enteroendocrine STC-1 cells. nitrogen distribution process, relative molecular weight (MW) peptides amino acid composition were characterized. Quinoa...
Oral squamous cell carcinoma (OSCC) is the most prevalent subtype of head and neck tumors, highly prone to lymph node metastasis. This study aims examine expression pattern Ras-related protein Rab-27A (RAB27A) explore its potential implications in OSCC. The RAB27A was assessed through immunohistochemical analysis utilizing tissue microarrays. In vitro experiments were conducted using RAB27A-knockdown cells investigate impact on OSCC tumor cells. Additionally, transcriptome sequencing...
Abstract Interferon-γ (IFN-γ), a key effector molecule in anti-tumor immune response, has been well documented to correlate with the intratumoral infiltration of cells. Of interest, however, high level IFN-γ reported salivary adenoid cystic carcinoma (SACC), which is actually type immunologically cold cancer few infiltrated Investigating functional significance SACC would help explain such paradoxical phenomenon. In present study, we revealed that, compared oral squamous cell cells (a hot...
Abstract High dielectric constant Ba 4 (Pr 0.4 Sm 0.6 ) 28/3 Ti 18− y Ga /3 O 54 (BPSTG) (0 ≤ 1) microwave ceramics with enhanced properties were synthesized via the traditional solid‐state processing for first time. The crystal structure, microstructure, and characteristics investigated in details. X‐ray diffraction results showed that all well‐sintered samples belonged to a single tungsten bronze type phase. Results partial substitution of 3+ 4+ is an effective way adjusting temperature...