A5010219004- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Asthma and respiratory diseases
- Vascular Tumors and Angiosarcomas
- Acute Myeloid Leukemia Research
- Histiocytic Disorders and Treatments
- Nasal Surgery and Airway Studies
- IL-33, ST2, and ILC Pathways
- Olfactory and Sensory Function Studies
- Head and Neck Surgical Oncology
Sichuan University
2017-2025
West China Hospital of Sichuan University
2017-2025
Background Although oxidative stress is involved in the pathophysiological process of chronic rhinosinusitis with nasal polyps (CRSwNP), specific underlying mechanism still unclear. Whether antioxidant therapy can treat CRSwNP needs further investigation. Methods Immunohistochemistry, immunofluorescence, western blotting and quantitative polymerase chain reaction (qPCR) analyses were performed to detect distribution expression oxidants antioxidants polyp tissues. qPCR revealed correlations...
Mast cells (MCs) are involved in type 2 inflammation chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)-33 stimulation. MiR-221 is reported to be an important regulator of MCs, and miR-221-3p can expressed CRSwNP. However, the role CRSwNP unclear. Ethmoid tissues from control subjects (n = 12) patients 40) were collected. The expression cytokines was detected by real-time quantitative polymerase chain reaction (qPCR). activation P65 ERK determined western...
Background CRSwNP is an inflammatory disease but the mechanism not yet fully understood. MiR-21, a member of miRNAs, has been reported to play roles in mediating inflammation. However, expression miR-21 and its role patients with remain elusive. Methods Turbinates from control subjects, uncinate processes CRSsNP, polyp tissues CRSwNP, nasal epithelial cells brushed mucosa were collected. The cytokines detected by qPCR. localization was ISH, target identified bioinformation analysis, qPCR,...
Abstract Introduction: Myeloid sarcoma (MS) is a rare tumor mass. It may occur at any extramedullary anatomic sites but uncommon in the sinonasal location.MS commonly presents concurrently with acute myeloid leukemia (AML), it predate AML over several months or years, named isolated MS. Patient concerns: We report case of 15-month-old child who presented mouth breathing, bilateral rhinorrhea, palpebral edema and proptosis. The routine blood tests were normal for first few months. Computed...
Nasopharyngeal carcinoma (NPC) is commonly diagnosed at an advanced stage with a high incidence rate in Southeast Asia and China. However, the limited availability of NPC patient survival data public databases has resulted less rigorous studies examining prediction through construction Kaplan-Meier curves. These have primarily relied on small samples patients progression-free (PFS) information or from head neck squamous cell (HNSCC) almost without patients. Thus, we coanalyzed RNA expression...
Abstract Nasopharyngeal carcinoma (NPC) is commonly diagnosed at an advanced stage with a high incidence rate in Southeast Asia and China. However, the limited availability of NPC patient survival data public databases has resulted less rigorous studies examining prediction through construction Kaplan-Meier curves. These have primarily relied on small samples patients progression-free (PFS) information or from head neck squamous cell (HNSCC) almost without patients. Thus, we coanalyzed RNA...