A5081504711- Circular RNAs in diseases
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Mesenchymal stem cell research
- Spinal Cord Injury Research
- Alzheimer's disease research and treatments
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Genetics and Neurodevelopmental Disorders
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Liver Disease and Transplantation
- RNA Research and Splicing
- Cardiac electrophysiology and arrhythmias
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- FOXO transcription factor regulation
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Bone fractures and treatments
- Nanoplatforms for cancer theranostics
- Photosynthetic Processes and Mechanisms
- Protist diversity and phylogeny
Zhengzhou University
2012-2024
Henan Provincial People's Hospital
2024
Hunan University
2023
Heidelberg University
2016-2021
Dongfeng General Hospital
2021
Shanghai Jiao Tong University
2021
General Hospital of Jinan Military Command
2015-2017
Air Force Medical University
2012-2015
Rationale: Extracellular vesicles (EVs) have emerged as novel mediators of cell-to-cell communication that are capable the stable transfer therapeutic microRNAs (miRNAs), and thus, EVs hold immense promise a miRNA delivery system for cancer therapy. Additionally, miRNA-containing secreted into circulation, miRNAs contained within plasma may represent ideal biomarkers diseases. The objective this study was to characterize potential tumor suppressor miRNA, miR-101, explore miR-101 via in vivo...
Metastasis is a leading cause of mortality for osteosarcoma patients. The molecular pathological mechanism remains to be elucidated. In the previously study, we established two cell lines with different metastatic potentials. Differential expressed genes and proteins regarding ability have been identified. MicroRNAs are important regulators in tumorigenesis tumor progression. this microRNA microarray was used assess differential miRNAs level between these lines. One top ranked miRNAs-miR-195...
Article16 April 2018free access Source DataTransparent process Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ regulation spine density, synaptic plasticity, cognition Max C Richter Institute Pharmacy Molecular Biotechnology (IPMB), Ruprecht-Karls University Heidelberg, Germany Search for more papers by this author Susann Ludewig Zoological Institute, Division Cellular Neurobiology, TU Braunschweig, Alex Winschel Department Biology, Neurophysiology und Neurosensory...
Studies have shown that miR-194 functions as a tumor suppressor and is associated with growth metastasis. We studied the effects of in osteosarcoma possible mechanism by which affected survival, apoptosis metastasis osteosarcoma. Both human cell lines SOSP-9607 U2-OS were transfected recombinant lentiviruses to regulate expression. Overexpression partially inhibited proliferation, migration, invasion cells vitro, well pulmonary vivo. Potential target genes predicted using bioinformatics....
Treatment of triple-negative breast cancer (TNBC) has long been a medical challenge because the lack effective therapeutic targets. Targeting lipid, carbohydrate, and nucleotide metabolism pathways recently proven as promising option in view three heterogeneous metabolic-pathway-based TNBC subtypes. Here, we present multimodal anticancer platinum(II) complex, named Pt(II)caffeine, with novel mode action involving simultaneous mitochondrial damage, inhibition metabolic pathways, promotion...
Xinxin Wang, Shanshan Ma, Nan Meng, Ning Yao, Kun Zhang, Qinghua Li, Yanting Qu Xing, Kang Han, Jishi Song, Bo Yang, and Fangxia Guan. Mol. Cells 2016;39:418-25. https://doi.org/10.14348/molcells.2016.2345
Article19 May 2021Open Access Transparent process Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, causes an autism-like phenotype Vicky Steubler Department Functional Genomics, Institute Pharmacy Molecular Biotechnology, Heidelberg University, Heidelberg, GermanyThese authors contributed equally to this work Search for more papers by author Susanne Erdinger Michaela K Back Pathophysiology, Focus Program Translational...
Amputation has been the standard surgical treatment for distal tibia osteosarcoma owing to its unique anatomic features. Preliminary research suggested that microwave-induced hyperthermia may have a role in treating some locations of body (such as pelvis), but our knowledge, no comparative study evaluated efficacy difficult-to-treat location like tibia.Does result (1) improved survival, (2) decreased local recurrence, (3) Musculoskeletal Tumor Society (MSTS) scores, or (4) fewer...
Transforming growth factor β (TGF-β) signaling plays a fundamental role in metazoan development and tissue homeostasis. However, the molecular mechanisms concerning ubiquitin-related dynamic regulation of TGF-β are not thoroughly understood. Using combination proteomics an siRNA screen, we identify pVHL as E3 ligase for SMAD3 ubiquitination. We show that directly interacts with conserved lysine proline residues MH2 domain SMAD3, triggering degradation. As result, level expression negatively...
Lung cancer remains the tumor with highest global incidence and mortality rates. Current primary treatment modalities encompass targeted therapy, immunotherapy, chemotherapy; however, a subset of patients derives no benefit from these interventions. Recently, HER2-targeting antibody drug Disitamab vedotin (RC48) was approved introduced primarily for gastric bladder cancers, minimal investigation in field lung cancer. This study demonstrates that FOXA1 directly binds to promoter region HER2,...
// Qinghua Li 1, 2, * , Lu Yang Kang Han Liqiang Zhu 3 Yanting Zhang 2 Shanshan Ma Kun Bo 1 Fangxia Guan The First Affiliated Hospital of Zhengzhou University, 450052, Henan Province, China School Life Sciences, 450001, Second 450002, These authors contributed equally to this work Correspondence to: Guan, email: guanfangxia@126.com Yang, yangbo96@126.com Keywords: Ets2, esophageal squamous cell carcinoma, proliferation, apoptosis, mTOR/p70S6K signaling pathway Received: December 10,...
Recent studies using animal models indicated that the members of amyloid precursor protein (APP) gene family are important for formation, maintenance, and plasticity synapses. Despite this, specific role APP homologues APLP1 APLP2 within CNS PNS is still poorly understood. In contrast to subtle phenotypes single mutants, double knockout mice (DKO) lacking APP/APLP2 or APLP1/APLP2 die first day after birth. Whereas APP/APLP2-DKO show severe deficits neuromuscular morphology transmission,...
Background and Objectives:The Osborn wave is the name designated to formation produced when there a large, prominent deviation of J point from baseline. The has been reported in many countries, but only 2 cases have Korea. Thus, purpose our study was evaluate clinical characteristics therapy hypothermia employing with Koreans. Subjects Methods:Between February 2001 April 2001, five patients visiting department were enrolled this study. We analyzed these for their distribution, symptoms...
Abstract Background: Glucocorticoids (GCs) injections are commonly used to relieve pain and improve function in patients with multiple shoulder disability, they cause detrimental effects on the rotator cuff tendons. Adipose stem cell-derived exosomes (ASC-Exos) reportedly recover impaired tendon matrix metabolism by maintaining tissue homeostasis. It is unclear whether additional ASC-Exos treatment overrides of GCs without interfering their anti-inflammatory effects. Methods: The vitro...