A5035408428- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Circular RNAs in diseases
- Hip disorders and treatments
- RNA Research and Splicing
- RNA modifications and cancer
- Blood transfusion and management
- Functional Brain Connectivity Studies
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Pain Mechanisms and Treatments
- Medical Imaging and Analysis
- Hip and Femur Fractures
- Rheumatoid Arthritis Research and Therapies
- Pelvic and Acetabular Injuries
- Bone and Joint Diseases
- interferon and immune responses
- Spine and Intervertebral Disc Pathology
- Knee injuries and reconstruction techniques
- Acupuncture Treatment Research Studies
- Scoliosis diagnosis and treatment
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
National University of Defense Technology
2019-2024
Institute of Computing Technology
2022-2023
Chinese Academy of Sciences
2016-2023
University of Chinese Academy of Sciences
2022-2023
Wuhan Institute of Physics and Mathematics
2021-2023
Key Laboratory of Guangdong Province
2022
Air Force Medical University
2012-2021
WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study investigated molecular mechanism exosomal miR-92a-3p and chondrogenesis cartilage degeneration.Exosomal expression was assessed vitro a human mesenchymal stem cell (MSC) model normal OA primary chondrocytes (PHCs). MSCs PHCs were treated with exosomes derived from MSC-miR-92a-3p (MSC-miR-92a-3p-Exos) or its antisense inhibitor (MSC-anti-miR-92a-3p-Exos), respectively. Small interfering RNAs (siRNAs) luciferase...
Background MicroRNAs (miRNAs) are a class of endogenously expressed, small noncoding RNAs, which suppress its target mRNAs at the post-transcriptional level. Studies have demonstrated that miR-34a, is direct p53 tumor suppressor gene, functions as and associated with growth metastasis various human malignances. However, role miR-34a in osteosarcoma has not been totally elucidated. In present study, effects on possible mechanism by affected were investigated. Methodology/Principal Finding...
Parkinson's disease (PD) is an age-dependent neurodegenerative that can be caused by genetic mutations in α-synuclein (α-syn) or duplication of wild-type α-syn; PD characterized the deposition α-syn aggregates, indicating a gain toxicity from accumulation α-syn. Although major neuropathologic feature degeneration dopaminergic (DA) neurons substantia nigra, non-motor symptoms including anxiety, cognitive defect and sleep disorder precede onset motor impairment, many clinical are not DA...
ObjectivesMicroRNAs (miRNAs) play an important role in the regulation of chondrogenesis mesenchymal stem cells, but their expression still remains unknown human adipose-derived cells (hADSCs). In this study miRNA profile during chondrogenic differentiation hADSC and potential mechanism whereby miRNAs may affect process are considered.MethodshADSCs were isolated cultured. The proteins was detected using enzyme-linked immunosorbent assay (ELISA). profiles before after induction obtained...
The current study aimed to identify gene signatures during rheumatoid arthritis (RA) and osteoarthritis (OA), used these elucidate the underlying modular mechanisms. Using Gene Expression Omnibus database, present obtained GSE7669 mRNA expression microarray data from RA OA synovial fibroblasts (n=6 each). differentially expressed genes (DEGs) in samples compared with were identified using Linear Models for Microarray Analysis package. Ontology Kyoto Encyclopedia of Genes Genomes pathway...
Enhanced recovery after surgery (ERAS) has rapidly gained popularity among hip or knee arthroplasty area which can decrease hospital length of stay (LOS). However, limited data exist regarding its safety and efficacy intertrochanteric fracture patients. The purpose this study was to determine if LOS associated with patients be improved following an existing orthopedic ERAS procedure.We reviewed the outcomes all who had been treated PFNA intramedullary fixation at our institution. Open...
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Chondrocyte senescence play an essential role in osteoarthritis (OA) progression. Recent studies have shown that snoRNA-derived RNA fragments (sdRNAs) are novel regulators of post-transcriptional gene expression. However, the expression profiles and their regulation chondrocyte OA progression is unknown. Here, we determined sdRNAs profile explored sdRNA-D43 its mechanism. We used qPCR arrays to determine chondrocytes areas undamaged damaged three knee samples. SdRNA-D43 was using...
Abstract The magnitude of Type I interferon (IFN) mediated innate immune response within the tumor microenvironment (TME) critically influences effectiveness radiotherapy. Unfortunately, due to a myriad resistance mechanisms, double‐stranded DNA (dsDNA) signals produced by cells postradiotherapy often induce diminished from cells. Through chemical screening targeting deubiquitinating enzymes, we identified USP1 (Ubiquitin Specific Peptidase 1) inhibitor as an enhancer post‐radiotherapy dsDNA...
Ruthenium-based anticancer complexes are promising antitumor agents for their low system toxicity and versatile chemical structures. Epidermal growth factor receptor (EGFR) has been found to be overexpressed in a broad range of tumor cells is regarded as drug target developing novel drugs. In this work, five ruthenium(II) polypyridyl containing EGFR-inhibiting 4-anilinoquinazoline pharmacophores were synthesized characterized. These showed both high activity strong DNA minor groove-binding...
Long noncoding RNAs (lncRNAs) play important roles in stem cell differentiation. However, their role osteogenesis of human adipose-derived cells (ASCs), a promising source for bone regeneration, remains unknown. Here, we investigated the expression profile and potential lncRNAs osteogenic differentiation ASCs.Human ASCs were induced to differentiate into osteoblasts vitro, profiles mRNAs undifferentiated differentiated obtained by microarray. Bioinformatics analyses including subgroup...
Aim: The molecular pathways regulating cartilage degradation are unclear. miR-381 was identified as a putative regulator of chondrogenesis related genes. Here, we examined its role in and osteoarthritic degeneration. Methods: expression assessed vitro response to IL-1β stimulation primary human (PHC) mouse (PMC) chondrocytes, ATDC5 derived chondrocytes; vivo embryos cartilage. effects on NF-kB signaling were using synthetic RNA mimic or inhibitor luciferase assay, respectively. Upstream...
Most circulating tumor cells (CTCs) die during the process of metastasis, but self-seeding CTCs can invade primary or form clinically meaningful metastases. This study aimed to evaluate capacity promote osteosarcoma growth and lung metastasis clarify specific role interleukin (IL)-8 in CTC self-seeding. We successfully isolated cultured through a nude mouse model established using green fluorescent protein (GFP)-labeled F5M2 found that exhibit increased cellular proliferation, migration,...
Purpose: Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease that affects the orbit and most prevalent extra-thyroidal complication of Graves’ disease. Previous neuroimaging studies have focused on abnormal static regional activity functional connectivity in patients with TAO. However, characteristics local brain over time are poorly understood. This study aimed to investigate alterations dynamic amplitude low-frequency fluctuation (dALFF) active TAO distinguish from healthy...
Mitochondrial dysfunction is related to the pathogenesis of osteoarthritis (OA); however, there are no effective drugs treat OA for maintaining mitochondrial homeostasis. Studies have shown that mitochonic acid-5 (MA-5) has a protective effect against damage and plays role in mitophagy. However, it not clear whether MA-5 beneficial on inflammatory articular cartilage. Here, human cartilage was obtained from patients undergoing total joint replacement. Interleukin-1β (IL-1β) used stimulate...
Application of chondrogenic growth factors is a routine strategy to induce chondrogenesis hMSCs, but they have economic and safety problems in the long term. It expected that scaffold material itself could play an important role hMSCs. In this study we tested whether novel tricalcium phosphate-collagen-hyaluronan (TCP-COL-HA) had inherent chondro-inductive capacity for both ATDC5 hMSCs without any exogenous vitro. were seeded onto TCP-COL-HA scaffolds cultured basal medium 3 weeks...
Objects: To investigate the value of CT-based 3D templating software for pre-operative planning in patients with acetabular dysplasia undergoing total hip arthroplasty (THA) a minimum follow-up 2 years. Methods: We performed retrospective review single surgeon's cohort Crowe I to III developmental dysplastic (49 hips 41 patients) who underwent cementless primary THA and were available at mean 2.7 years after THA. analyzed accuracy cup size prediction, reliability pre- post-operative...