A5113903050- CAR-T cell therapy research
- Conducting polymers and applications
- Pulmonary Hypertension Research and Treatments
- Virus-based gene therapy research
- Nitric Oxide and Endothelin Effects
- Advanced Sensor and Energy Harvesting Materials
- Eicosanoids and Hypertension Pharmacology
- Viral Infectious Diseases and Gene Expression in Insects
- Neonatal Respiratory Health Research
- Nanowire Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Perovskite Materials and Applications
- Organic Electronics and Photovoltaics
- Innovative Energy Harvesting Technologies
- Renin-Angiotensin System Studies
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Pregnancy and preeclampsia studies
- Neuroscience and Neural Engineering
- vaccines and immunoinformatics approaches
- HIV, Drug Use, Sexual Risk
- Acute Ischemic Stroke Management
- Data-Driven Disease Surveillance
- Speech Recognition and Synthesis
- Platelet Disorders and Treatments
Kunming Medical University
2025
Sichuan University
2019-2025
Sun Yat-sen University
2025
Stomatology Hospital
2025
Jinan University
2025
State Key Laboratory of Biotherapy
2019-2024
Guangxi University
2022-2024
Beijing Institute of Nanoenergy and Nanosystems
2024
Chinese Academy of Sciences
2024
Southwest University
2023
Cancer immunotherapy is revolutionizing oncology and has emerged as a promising strategy for the treatment of multiple cancers. Indoleamine 2,3-dioxygenase 1 (IDO1), an immune checkpoint, plays important role in tumor escape through regulation cells been regarded attractive target cancer immunotherapy. Proteolysis Targeting Chimeras (PROTAC) technology new model drug research development its advantageous mechanism. Herein, we reported application PROTAC targeted degradation IDO1, leading to...
Thermobifida fusca Cel9A-90, an unusual family 9 enzyme, is a processive endoglucanase containing catalytic domain closely linked to 3c cellulose binding (Cel9A-68) followed by fibronectin III-like and 2 domain. To study its mechanism, 12 mutant genes with changes in five conserved residues of Cel9A-68 were constructed, cloned, expressed Escherichia coli. The purified enzymes assayed for their activities on (carboxymethyl)cellulose, phosphoric acid-swollen cellulose, bacterial...
Pericytes are known to regulate brain capillary endothelial functions. The purpose of this study was define the hemostatic regulatory role human pericytes. We used blood–brain barrier models consisting pericytes grown on transwell membrane inserts and cocultured with microvascular cells (HBEC), or in direct contact HBEC. When cocultures which were physically separated from cells, induced significant changes tissue plasminogen activator (tPA) messenger ribonucleic acid (mRNA) protein: tPA...
It is an increasingly mature application solution that triboelectric nanogenerator (TENG) supplies power to electronic devices through its management system (PMS). However, the previous PMS able manage a limited voltage magnitude and energy storage elements are capacitors. This work proposes ultrahigh (UV-PMS) realize charging of commercial lithium cells (LCs) by TENG. The design UV-PMS enables TENGs with open-circuit voltages up 3500 V boosts peak current from 30.9 µA 2.77 mA, increase...
An increase in Rho kinase (ROCK) activity is implicated chronic hypoxia-induced pulmonary hypertension. In the present study, we determined role of ROCKs cGMP-dependent protein (PKG)-mediated vasodilation fetal lambs exposed to hypoxia. Fourth generation arteries were isolated from near-term fetuses ( approximately 140 days gestation) delivered ewes high altitude hypoxia for 110 and control ewes. vessels constricted endothelin-1, 8-bromoguanosine-cGMP (8-Br-cGMP) caused a smaller relaxation...
PttCel9A is a membrane-bound, family 9 glycosyl hydrolase from Populus tremula x tremuloides that upregulated during secondary cell wall synthesis. The catalytic domain of PttCel9A, Delta(1-105)PttCel9A, was purified, and its activity compared to TfCel9A TfCel9B Thermobifida fusca. Since aromatic amino acids involved in substrate binding at subsites -4, -3, -2 are missing the mutant enzymes W256S, W209A, W313G also investigated. Delta(1-105)PttCel9A hydrolyzed comparatively narrow range...
Chronic hypoxia triggers pulmonary vascular remodeling, which is associated with a modulation of the smooth muscle cell (SMC) phenotype from contractile, differentiated to synthetic, dedifferentiated state. We previously reported that acute represses cGMP-dependent protein kinase (PKG) expression in ovine fetal venous SMCs (FPVSMCs). Therefore, we tested if altered PKG could explain SMC after exposure hypoxia. Hypoxia-induced reduction strongly correlated repressed markers, myosin heavy...
Abstract mRNA‐based gene therapy has emerged as an advanced strategy for hepatocellular carcinoma (HCC) treatment. However, one of its main limitations is lacking delivery precision in vivo. Distinguishing HCC cells from other tissues crucial maintaining the high stability, positive therapeutic outcomes, and safety mRNA therapeutics. Here, a novel specific peptide HCC167 developed by phage display. It shown that can specifically recognize variety substrates including patient samples with...
Defects in software may result system crashes, sluggish performance, or even deadlock, leading to the depletion of valuable resources. Implementing defect prediction can assist quality assurance teams identifying potential issues and rationalizing allocation testing resources, thereby decreasing elimination resources enhancing sustainability. Researchers have recently incorporated deep learning into prediction, extracting structural-semantic features from codes' abstract syntax trees (ASTs)....
Abstract The magnitude of Type I interferon (IFN) mediated innate immune response within the tumor microenvironment (TME) critically influences effectiveness radiotherapy. Unfortunately, due to a myriad resistance mechanisms, double‐stranded DNA (dsDNA) signals produced by cells postradiotherapy often induce diminished from cells. Through chemical screening targeting deubiquitinating enzymes, we identified USP1 (Ubiquitin Specific Peptidase 1) inhibitor as an enhancer post‐radiotherapy dsDNA...
Abstract Organic solar cells (OSCs) have become a promising photovoltaic technology, achieving high efficiencies over 20%. However, simplifying processing techniques to maintain performance remains significant challenge. This work reports series of Y6‐derived non‐fullerene acceptors (NFAs), namely BTP‐R1F, BTP‐R2F, BTP‐R3F, and BTP‐R5F, featuring fluorinated phenoxyoctyl side chains with varying numbers fluorine atoms. Systematic fluorination has minimal impact on optical absorption energy...
Glioblastoma (GBM) is the most common and lethal brain tumor with limited therapeutic strategies incomplete studies on its progression mechanisms. This study aims to reveal potential prognostic marker genes associated GBM cell invasion, establish an effective model for patients. Differentially expressed (DEGs) were screened from The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA), differentially invasive-related was obtained, qRT-PCR used verify gene expression. risk scores of individual...
Abstract Aim Recent findings suggest that mitigating ferroptosis could serve as an effective strategy for treating inflammation. This study aimed to investigate the role enhancer of zeste homologue 2 ( EZH2 ) mediated signal transducer and activator transcription 3 stat3 methylation plays in modulation pulpitis. The results offer potential advancements therapeutic approaches pulpitis provide new insights strategies managing this condition. Methodology Bioinformatics analysis combined with...
Abstract This work addresses the challenge of achieving advanced fibril morphology non‐fullerene acceptors (NFAs) in layer‐by‐layer organic solar cels (LBL‐OSCs) by cycloalkyl chain strategy, focusing on ta series Y6‐type NFAs, namely BTP‐C6, BTP‐C8 and BTP‐C12, featured with cyclohexyl, cyclooctyl cyclododecyl chains increasing steric hindrance. These side influenced significantly molecular planarity, packing film morphology, which are critical for device performance. BTP‐C6 exhibits...