Most circulating tumor cells (CTCs) die during the process of metastasis, but self-seeding CTCs can invade primary or form clinically meaningful metastases. This study aimed to evaluate capacity promote osteosarcoma growth and lung metastasis clarify specific role interleukin (IL)-8 in CTC self-seeding. We successfully isolated cultured through a nude mouse model established using green fluorescent protein (GFP)-labeled F5M2 found that exhibit increased cellular proliferation, migration,...

Backpacks are widely used as an efficient and convenient means for manual load transportation. However, carrying heavy loads a long time can significantly increase the risk of health issues. In response to growing demand relieving muscle fatigue, this paper proposes energy-saving backpack that adapt effectively variable walking speeds masses. Inspired by traditional bamboo pole commonly transporting goods, theory based on its mechanical characteristics is proposed. Guided theory, designed...

The accurate perception of external environment information through the robot foot is crucial for mobile to evaluate its ability traverse terrain. Adequate foot-end contact signals can provide robust support motion control and decision-making processes. shape uncertain rotation wheel-legged end represent a significant challenge sensing state, which current schemes cannot solve. This paper presents method tire stress field robots. A finite element analysis was conducted study deformation...

In this paper we present a method for optimal control of nonlinear highly realistic helicopter model based on combination neural network (NN) feedback controller and state-dependen t Riccati equation (SDRE) controller. Optimization the NN is performed within receding horizon predictive (MPC) framework, subject to dynamic kinematic constraints. The SDRE utilizes simplified 6DOF rigid body model, augments by providing an initial feasible solution improving stability. While provides robustness...

Abstract The dual reciprocity boundary element method, first proposed by Nardini and Brebbia (1982, 1985), is a powerful technique for solving elliptic partial differential equations. Adopting this approach, singular volume integral, which needs to be evaluated with traditional can converted into integral. However, when the governing equation of certain type, conversion fails due singularities being introduced inside physical domain on arising differentiating distance functions. We avoid...

Carrying a load can affect human locomotion and increase the risk of musculoskeletal injuries. In this letter, we proposed method inspired by running posture ungulate species to reduce metabolic energy controlling motion. We developed an energy-saving exoskeleton with active CoM adjustment system, which enables accurate control acceleration using disturbance rejection (ADRC) technology. Finally, tested results showed <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Abstract An analytical solution of a two-dimensional bow and stern flow model based on flat ship theory is presented for the first time. The counterpart to Michell's thin leads mixed initial-boundary value problem, which usually difficult solve analytically. Starting from transient we shall show that steady state attainable at large time limit. Then problem solved in detail by means Wiener-Hopf technique closed-form far-field results are obtained an arbitrary hull shape. Apart providing...

To understand the research trends and areas of focus regional development, this study conducted bibliometric based on Science Citation Index Expanded Social databases. The presents a comprehensive overview field development by exploring its annual output, journals, countries, institutions, temporal keyword trends, citations, high-impact authors. countries that had greatest academic impact were United Kingdom States, University California, Los Angeles, was institution highest relative...

In this paper, we compare the direct boundary element method (BEM) and dual reciprocity (DRBEM) for solving interior Helmholtz problem, in terms of their numerical accuracy efficiency, as well applicability reliability frequency domain. For BEM formulation, there are two possible choices fundamental solutions, which can lead to quite different conclusions DRBEM it is shown that although DBREM correctly predict eigenfrequencies even higher modes, fails yield a reasonably accurate solution...

Abstract Vehicle routing problem with time windows (VRPTW), which is a typical NP-hard combinatorial optimization problem, plays an important role in modern logistics and transportation systems. Although the particle swarm (PSO) algorithm exhibits very promising performance on continuous problems, how to adapt PSO efficiently deal VRPTW still challenging work. In this paper, we propose neighborhood comprehensive learning (N-CLPSO) solve VRPTW. To improve exploitation capability of N-CLPSO,...

Abstract In this study, D-galactose was used to establish a model of liver dysfunction caused by oxidative stress in mice, and the effect dandelion on improving exercise capacity mice with observed its mechanism expounded. This study examined role running ability, swimming endurance, blood biochemical indices, histopathological changes, tissue mRNA expression changes. The animal results showed that extended time exhaustion dysfunctional reduced serum levels urea nitrogen (BUN), lactic acid...

In daily life, human beings always carry different loads for activities. Some can be classified as coronal plane due to the location of their center-of-mass. When carrying loads, need consume more energy compensate torque generated by which leads extra muscle fatigue. this paper, we proposed a method changing motion center-of-mass change activities body save energy. A passive exoskeleton was investigated and experiments were conducted validate effectiveness exoskeleton. The results have...

Long time walking with heavy load can cause irre-versible muscle damage. The research shows that spring damping systems effectively change the phase difference between suspended backpack and wearer. In this paper, mechanism of is analysed a method for selecting appropriate coefficient proposed. Based on requirement stiffness transformation, variable reduction adaptively size weight designed. And test was carried out using prototype to verify correctness theory.

Moxibustion is a traditional Chinese medical therapy, which has good effect on preventing and treating diseases. However, the moxibustion method problems such as extended time repetitive labor. Therefore, mobile robot system been designed constructed in this paper, can autonomously navigate indoors simulate manual therapy. The functional requirements of were initially analyzed, overall scheme was designed. Subsequently, localization navigation based AprilTag technology proposed for...