A5103015045- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiovascular and Diving-Related Complications
- Cerebrovascular and genetic disorders
- Neurological diseases and metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Health and Disease Prevention
- Genetic Neurodegenerative Diseases
- Atrial Fibrillation Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Hereditary Neurological Disorders
- Cerebral Venous Sinus Thrombosis
- Body Composition Measurement Techniques
- Cardiovascular Health and Risk Factors
- Lysosomal Storage Disorders Research
- Fibroblast Growth Factor Research
- Ubiquitin and proteasome pathways
- Effects of Radiation Exposure
- Peripheral Artery Disease Management
- Cellular transport and secretion
- Oral Health Pathology and Treatment
- 14-3-3 protein interactions
First Affiliated Hospital of Zhengzhou University
2013-2025
Chengdu University
2024
Qingdao University of Science and Technology
2021
Harvard University
2020
Massachusetts General Hospital
2017-2020
Southerners on New Ground
2017-2019
Shenyang Normal University
2018
National Institute of Neurological Disorders and Stroke
2015
Zhengzhou University
2013
Torino e-district
2013
Gordon Holmes syndrome (GHS) is a rare Mendelian neurodegenerative disorder characterized by ataxia and hypogonadism. Recently, it was suggested that disordered ubiquitination underlies GHS though the discovery of exome mutations in E3 ligase RNF216 deubiquitinase OTUD4. We performed sequencing family with two three siblings afflicted hypogonadism identified homozygous mutation STUB1 (NM_005861) c.737C→T, p.Thr246Met, gene encodes protein CHIP (C-terminus HSC70-interacting protein). plays...
Cerebral small vessel disease (CSVD) is a global brain disorder that characterized by series of clinical, neuroimaging, and neuropathological manifestations. However, the molecular pathophysiological mechanisms CSVD have not been thoroughly investigated. Liquid chromatography-tandem mass spectrometry-based proteomics has broad application prospects in biomedicine. It used to elucidate disease-related processes pathways, thus providing an important opportunity explore CSVD. Serum samples were...
Background and Purpose— The Age, Blood Pressure, Clinical Features, Duration, Diabetes plus Dual TIA (ABCD 3 -I) score is recommended to predict the risk of early stroke after transient ischemic attack. aim this study was validate predictive value ABCD -I compare accuracy 2 ) scores in a Chinese population. Methods— Data were prospectively collected from patients who had attack, as defined by World Health Organization time-based criteria. available within 7 days index outcome occurrence at...
Collateral pathways are important in maintaining adequate cerebral blood flow patients with carotid stenosis. We aimed to evaluate the hemodynamic patterns relation stenosis acute stroke patients. Consecutive 586 a hospital based cohort were included present study. Carotid duplex was performed identify absolute minimal diameter reductions of 50 % or greater their internal arteries (ICAs). Color velocity imaging quantification ultrasound (CVIQ) used measure extracranial arterial volume (BFV)...
Background: Previous studies conflicted in the association between intracranial atherosclerotic stenosis (ICAS) and severity of white matter changes (WMC). Aims: We aimed to investigate relationships luminal hemodynamic significance middle cerebral artery (MCA) stenosis, ipsilateral WMC. Methods: In this cross-sectional study, patients with a recent ischemic stroke or transient attack 50-99% MCA-M1 Chinese Intracranial Atherosclerosis study cohort were analyzed. The post- pre-stenotic signal...
Abstract Background Using random forest to predict arrhythmia after intervention in children with atrial septal defect. Methods We constructed a prediction model of complications interventional closure for The was based on forest, and it solved the need postoperative risk assisted clinicians patients’ families make preoperative decisions. Results Available models provided patients specific factor assessments, we used Synthetic Minority Oversampling Technique algorithm machine learning...
Hereditary motor and sensory neuropathy (HMSN), also known as Charcot-Marie-Tooth disease (CMT), is a genetically heterogeneous disorder that affects both peripheral nerves. HMSN characterized by distal symmetric muscle atrophy in the lower limbs hands, foot abnormalities, loss. It associated with more than 50 causative genes or loci; however, genetic cause remains undetermined almost 50% of cases.1,2
Abstract It is essential to identify high risk transient ischemic attack (TIA) patients. The previous study reported that the CSR (comprehensive stroke recurrence) model, a neuroimaging had predictive ability of recurrent stroke. aims this were validate value model in TIA patients and compare with ABCD 3 -I score. Data analyzed from prospective hospital-based database which defined by World Health Organization time-based criteria. outcome was occurrence at 90 days. receiver-operating...
Background: Early neurological deterioration (END) was common in single small subcortical infarction (SSSI). Distal type of SSSI (dSSSI) reported to have a lower risk END than proximal (pSSSI) lenticulostriate artery(LSA) territory. However, dSSSIs with different lesion thickness might risks END. Keywords: Subcortical infarction, pattern, early deterioration, DWI, LSA, MRI.
The aim of this investigation was to examine the association between serum homocysteine (Hcy) level and distal single small subcortical infarction (dSSSI).Consecutive patients were prospectively recruited in a registered hospital-based ischemic stroke database. Baseline characteristics risk factors (SSSI), including Hcy level, assessed. SSSI located lenticulostriate artery (LSA) territory divided into proximal (pSSSI) dSSSI based on standard template axial diffusion-weighted imaging (DWI)....
<title>Abstract</title> Background Cerebral small vessel disease (CSVD) is a global brain disorder that characterized by series of clinical, neuroimaging, and neuropathological manifestations. However, the molecular pathophysiological mechanisms CSVD have not been thoroughly investigated. Liquid chromatography-tandem mass spectrometry-based proteomics has broad application prospects in biomedicine. It used to elucidate disease-related processes pathways, thus providing an important...
Abstract Intracerebral hemorrhage (ICH) is generally considered to be closely related cerebral small vessel disease (CSVD), leading a poor prognosis. However, the coexistence of ICH in general CSVD patients and factors remain underreported. In our cross-sectional study, we screened 414 from database at Department Neurology, First Affiliated Hospital Zhengzhou University (September 2018 April 2022). Imaging biomarkers coexisting lesion were assessed. Factors associated with determined using...
Dermal fibroblasts obtained from a 43-year-old healthy man were successfully transformed into induced pluripotent stem cells (iPSCs) by employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and l-MYC. The iPSCs showed normal karyotype exhibited the potential to differentiate three germ layers in teratoma assay, which is often used assess pluripotency of cells. This iPSC line may be subsequently for drug screens, biological tissue engineering, cell transplantations.
Background: Hereditary hypercoagulation is an important risk factor in patent foramen ovale (PFO) related cryptogenic stroke (CS). Body mass index (BMI) has been associated with venous thrombosis by genetic and hereditary factors. Since the pathogenesis of PFO-related considered to be due paradoxical thrombus from system, it imperative explore relationship between BMI. Methods: Eligible patients were consecutively prospectively recruited accordance IRB. All underwent full evaluation...