A5026999160- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Ultrasound in Clinical Applications
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Fetal and Pediatric Neurological Disorders
- Ultrasound Imaging and Elastography
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Anesthesia and Neurotoxicity Research
- Radiation Dose and Imaging
- Mechanical Circulatory Support Devices
- Pediatric Hepatobiliary Diseases and Treatments
- Cell death mechanisms and regulation
- Hemodynamic Monitoring and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Urology and Nephrology Studies
- Atomic and Subatomic Physics Research
- Infant Nutrition and Health
- Autophagy in Disease and Therapy
- Urological Disorders and Treatments
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
Children's Hospital of Philadelphia
2018-2025
University of Pennsylvania
2018-2025
Philadelphia University
2020-2024
University of Michigan
2024
Moss Landing Marine Laboratories
2023
Sigma Theta Tau International
2023
University of Pennsylvania Health System
2022
Samsung (South Korea)
2022
Johns Hopkins Hospital
2017-2021
Lucile Packard Children's Hospital
2020
Single-crystal polythiophene microwires with unprecedented electrical characteristics such as low resistance (0.5 MΩ), a channel current high 25 μA, and well-resolved gate modulation (see figure) have been obtained by specific control over the supramolecular organization of individual polymer chains, which show preferential well-ordered interchain stacking along wire axis. This approach offers promising protocol for new flexible electronics.
Autophagy has been reported to be increased in irradiated cancer cells resistant various apoptotic stimuli. We therefore hypothesized that induction of autophagy via mTOR inhibition enhances radiosensitization apoptosis-inhibited H460 lung vitro and a xenograft model. To test this hypothesis, combinations Z-DEVD (caspase-3 inhibitor), RAD001 (mTOR inhibitor) irradiation were tested cell mouse models. The combination more potently radiosensitized than individual treatment alone. enhancement...
Ultrasound is a safe bedside imaging tool that obviates the use of ionizing radiation diagnostic procedures. Due to its convenience, lung ultrasound has received increasing attention from neonatal physicians. Nevertheless, clear reference standards and guideline limits are needed for accurate application this modality. This document aims summarize expert opinions provide precise guidance help facilitate in diagnosis diseases.
Background Radiographic measurement of leg length discrepancy (LLD) is time consuming yet cognitively simple for pediatric radiologists. Purpose To compare deep learning (DL) measurements LLD in patients to performed by Materials and Methods For this HIPAA-compliant retrospective study, radiographs obtained evaluate children between January August 2018 were identified. was automatically measured means image segmentation followed calculation. On training data, a DL model trained segment...
Abstract Affecting 1.1‰ of infants, hydrocephalus involves abnormal accumulation cerebrospinal fluid, resulting in elevated intracranial pressure (ICP). It is the leading cause for brain surgery newborns, often causing long-term neurologic disabilities or even death. Since conventional invasive ICP monitoring risky, early neurosurgical interventions could benefit from noninvasive techniques. Here we use clinical contrast-enhanced ultrasound (CEUS) imaging and intravascular microbubble...
Abstract With a spatial resolution of tens microns, ultrasound localization microscopy (ULM) reconstructs microvascular structures and measures intravascular flows by tracking microbubbles (1–5 μm) in contrast enhanced (CEUS) images. Since the size CEUS bubble traces, e.g. 0.5–1 mm for with wavelength λ = 280 μm, is typically two orders magnitude larger than diameter, accurately localizing noisy data vital to fidelity ULM results. In this paper, we introduce residual learning based...
To evaluate magnetic resonance (MR) imaging findings of the spine in patients with Guillain-Barré syndrome.MR eight (three male, five female; age range, 2-47 years) syndrome were retrospectively reviewed. was diagnosed mainly on basis symptoms and also supportive ancillary data, such as results cerebrospinal fluid analysis electrophysiologic evaluation. In addition, follow-up MR performed three patients, who had slight clinical improvement.All thickening intrathecal spinal nerve roots cauda...
Abstract: Melatonin, the main secretory product of pineal gland, has been shown to exert an oncostatic activity in cancer cells. Recently, several studies have that melatonin antiangiogenic properties. However, mechanism by which exerts antiangiogenenic effects is not understood. Hypoxia inducible factor (HIF)‐1 a transcription mediates adaptive response changes tissue oxygenation. HIF‐1 heterodimer formed association constitutively expressed HIF‐1β subunit and HIF‐1α subunit, expression...
Significance Toll-like receptors (TLRs) are key innate immune that sense pathogen- or danger-associated molecules. The members of the TLR family can be classified into two groups based on their subcellular localization patterns—cell surface vs. endolysosomes—but how individual is targeted to its destination largely unknown. UNC93B1 was regarded specifically bind endolysosomal TLRs in endoplasmic reticulum and deliver them endolysosomes with no role for surface-localized TLRs. In this study,...
Ultrasound is a safe bedside imaging tool that obviates the use of ionizing radiation diagnostic procedures. Due to its convenience, lung ultrasound has received increasing attention from neonatal physicians. Nevertheless, clear reference standards and guideline limits are needed for accurate application this modality. This document aims summarize expert opinions provide precise guidance help facilitate in diagnosis diseases.
OBJECTIVE The current neurosurgical treatment for intraventricular hemorrhage (IVH) of prematurity resulting in posthemorrhagic hydrocephalus (PHH) seeks to reduce intracranial pressure with temporary and then permanent CSF diversion. In contrast, neuroendoscopic lavage (NEL) directly addresses the blood that is hypothesized damage ependyma parenchyma, leading ventricular dilation hydrocephalus. authors sought determine feasibility NEL PHH. METHODS records patients a diagnosis grade III or...
Objectives/Goals: The timing of neurosurgery is highly variable for post-hemorrhagic hydrocephalus (PHH) prematurity. We sought to utilize microvascular imaging (MVI) in ultrasound (US) identify biomarkers discern the opportune time intervention and analyze cerebrospinal fluid (CSF) characteristics as they pertain neurosurgical outcome. Methods/Study Population: inclusion criteria study are admission neonatal intensive care unit (NICU) with a diagnosis Papile grade III or IV. Exclusion...
Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, improved survival neonates with hypoxic ischemic injury. Contrast‐enhanced ultrasound (US) imaging a novel technique in which intravenously injected gas‐filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast‐enhanced 2 injury future directions on developing quantitative techniques for characterization abnormalities. The...
Objectives To investigate whether quantitative contrast‐enhanced ultrasound (CEUS) can accurately identify neonates and infants with hypoxic ischemic brain injury. Methods In this prospective cohort study, 8 a suspicion of injury were evaluated CEUS. Results An interesting trend was observed in the central gray nuclei–to–cortex perfusion ratios. The ratios at peak enhancement, wash‐in area under curve, index, maximum slopes lower all affected cases compared to normal group but not...