A5045760355- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neural Engineering
- Nicotinic Acetylcholine Receptors Study
- Meningioma and schwannoma management
- Intracerebral and Subarachnoid Hemorrhage Research
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Cardiac Ischemia and Reperfusion
- Neurosurgical Procedures and Complications
- Signaling Pathways in Disease
- Anesthesia and Neurotoxicity Research
- Metabolism and Genetic Disorders
- Vascular Malformations Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Ultrasound in Clinical Applications
- S100 Proteins and Annexins
- Transcranial Magnetic Stimulation Studies
- Photoreceptor and optogenetics research
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Listeria monocytogenes in Food Safety
- Salmonella and Campylobacter epidemiology
Hospital of the University of Pennsylvania
2023
University of Pennsylvania
2021-2023
Children's Hospital of Philadelphia
2022
Philadelphia University
2022
Johns Hopkins University
2017-2021
Johns Hopkins Medicine
2017-2020
Johns Hopkins Hospital
2017-2020
Neurological Surgery
2012-2018
University of Pittsburgh Medical Center
2012-2018
Kennedy Krieger Institute
2017-2018
Explosive blast-induced traumatic brain injury (TBI) is the signature insult in modern combat casualty care and has been linked to post-traumatic stress disorder, memory loss, chronic encephalopathy. In this article we report on mild TBI (mTBI) characterized by fiber-tract degeneration axonal revealed cupric silver staining adult male rats after head-only exposure 35 psi a helium-driven shock tube with head restraint. We now explore pathways of secondary repair using biochemical/molecular...
The Kryptopterus bicirrhis (glass catfish) is known to respond electromagnetic fields (EMF). Here we tested its avoidance behavior in response static and alternating magnetic stimulation. Using expression cloning identified an perceptive gene (EPG) from the K. encoding a protein that responds EMF. This EPG was cloned expressed mammalian cells, neuronal cultures rat's brain. Immunohistochemistry showed of confined cell membrane. Calcium imaging cells cultured neurons expressing demonstrated...
Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, improved survival neonates with hypoxic ischemic injury. Contrast‐enhanced ultrasound (US) imaging a novel technique in which intravenously injected gas‐filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast‐enhanced 2 injury future directions on developing quantitative techniques for characterization abnormalities. The...
For patients with traumatic brain injury (TBI), current clinical imaging methods generally do not provide highly detailed information about the location of axonal injury, severity or expected recovery. In a case severe TBI, authors applied novel high-definition fiber tracking (HDFT) to directly visualize and quantify degree damage predict functional deficits due loss cortical projections. This 32-year-old man sustained TBI. Computed tomography MRI revealed an area hemorrhage in basal ganglia...
Brainstem cavernous malformations (CMs) are challenging due to a higher symptomatic hemorrhage rate and potential morbidity associated with their resection. The authors aimed preoperatively define the relationship of CMs perilesional corticospinal tracts (CSTs) by obtaining qualitative quantitative data using high-definition fiber tractography. These were examined postoperatively longitudinal scans in relation patients' symptomatology. extent involvement CST was further evaluated...
To establish the clinical relevance of porcine model traumatic brain injury (TBI) using plasma biomarkers with diffusion tensor imaging (DTI) over 30 days, we performed a randomized, blinded, pre-clinical trial Yorkshire pigs weighing 7-10 kg. Twelve were subjected to Sham (n = 5) by skin incision or TBI 7) controlled cortical impact. Blood samples collected before injury, then at approximately 5-day intervals until days. Both groups also had DTI 24 h and days after injury. Plasma isolated...
OBJECT Stereotactic radiosurgery (SRS) is a therapeutic option for repeatedly hemorrhagic cavernous malformations (CMs) located in areas deemed to be high risk resection. During the latency period of 2 or more years after SRS, recurrent hemorrhage remains persistent until obliterative process has finished. The pathological response SRS been studied relatively few patients. authors present study aimed gain insight into effect on CM and propose possible mechanisms leading hemorrhages following...
Previous studies on the therapeutic potential of agents affecting dopamine system in traumatic brain injury (TBI) suggest that dysregulation may have a major role behavioral deficit after TBI. We previously identified TBI reduces striatal synthesis and release at 7 days post-injury. In order to reverse deficits activity tyrosine hydroxylase following TBI, we administered nicotine by intraperitoneal injection into rats for days. Tyrosine assay demonstrated recovery with treatment injured...
Spontaneous intracerebral hemorrhages (ICHs) cause significant morbidity and mortality. Traditional open surgical management strategies offer limited benefit except for the most superficial in select patients. Recent reports suggest that endoscopic approaches may improve outcomes, particularly deep subcortical hemorrhages. However, of these patients remains controversial. We reviewed our experience using port surgery to identify characteristics predict acceptable outcomes.We completed a...