A5101677998- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Signaling Pathways in Disease
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Protein Tyrosine Phosphatases
- Adipose Tissue and Metabolism
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Hemodynamic Monitoring and Therapy
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Risk Factors
- Industrial Technology and Control Systems
- Ginseng Biological Effects and Applications
- ATP Synthase and ATPases Research
- Manufacturing Process and Optimization
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Aortic aneurysm repair treatments
- Receptor Mechanisms and Signaling
Shanghai University of Traditional Chinese Medicine
2016-2025
Shanghai East Hospital
2019-2025
Chinese PLA General Hospital
2020-2024
Union Hospital
2020
Jilin University
2009-2020
Shuguang Hospital
2015-2019
University of North Carolina at Greensboro
2017
National Heart Centre Singapore
2016
Pennington Biomedical Research Center
2013
Shanghai University
2012-2013
In heart failure (HF), energy metabolism pathway in cardiac muscle changes from fatty acid β-oxidation to glycolysis. However, the exact mechanism is unknown. Sarcoendoplasmic reticulum Ca2+α ATPase (SERCA) expression downregulated and mitochondrial function reduced HF, perhaps partly due a substantially supply for excitation-contraction coupling resulting lower rate. We investigated whether Astragaloside IV can activate peroxisome proliferator-activated receptor alpha (PPARα) stimulate...
Background: Autophagy is required for the maintenance of cardiomyocyte homeostasis. However, excessive autophagy plays a maladaptive role in pressure overload-induced heart failure. To identify mechanisms by which Stachydrine inhibits cardiac hypertrophy, we determined inhibitory activities against activation NADPH oxidase, reactive oxygen species(ROS) production and autophagy. Methods: was administered intragastrically to Wistar rats after Transverse aortic constriction(TAC) H9c2 cells were...
Objective: To investigate the correlation between hemodynamic pattern of non-culprit vessel stenosis and long-term vessel-oriented composite outcome(VOCO) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: From January 2019 to December 2021, 233 consecutive STEMI were prospectively enrolled at Shanghai East Hospital. The median follow-up duration was 3.9 years. 367 vessels divided into VOCO group (33 vessels, 9.0%) non-VOCO (334 91.0%). Parameters pertaining...
Cardiovascular diseases, the leading cause of death worldwide, are tightly associated with pathological myocardial fibrosis. Stachydrine (Sta), a major active compound in Chinese motherwort Leonurus heterophyllus, was reported to effectively attenuate cardiac fibrosis, but detailed cellular and molecular mechanism remained unclear. In this study, anti-fibrotic effect Sta were explored mouse model pressure overload AngII stimulated fibroblasts (CFs). Mice randomly divided into sham,...
Leonurus heterophyllus sweet has been suggested to have cardioprotective effects against heart diseases, including ischemic diseases and ventricular remodeling. However, the active ingredients of herb underlying mechanisms are poorly understood. The aim present study was investigate stachydrine (STA), a major constituent sweet, on norepinephrine (NE) induced hypertrophy changes calcium transients in neonatal rat cardiomyocytes.Ventricular myocytes from 1-day-old Wistar rats were isolated...
Shengmai San (SMS), prepared from Panax ginseng, Ophiopogon japonicus, and Schisandra chinensisin, has been widely used to treat ischemic disease. In this study, we investigated whether SMS may exert a beneficial effect in diabetic cardiomyopathy through improvement of mitochondrial lipid metabolism.A leptin receptor-deficient db/db mouse model was utilized, lean age-matched C57BLKS mice served as non-diabetic controls. Glucose profiles, myocardial structure, dimension, function, heart...
Background: Cardiovascular diseases have become a major public health problem that seriously threatens human health. The cumulative effects of various cardiovascular events will eventually develop into chronic heart insufficiency and even failure, the β1 adrenergic receptor signal pathway plays an important role in this process. Stachytine hydrochloride is main active ingredient Yimucao, which traditional Chinese medicine used to treat gynecological diseases. Modern studies found stachytine...
The transcription factor NF-κB p65 is a key regulator in the regulation of an inflammatory response and pathology atherosclerosis. However, there no direct evidence for role macrophages development We investigated whether macrophage overexpression apoE-knockout mice could improve Transgenic (Tg) overexpressing were generated by crossing fatty acid-binding protein 4 (aP2) promoter-controlled with (KO) mice. Tg exhibited functional activation signaling fat tissues. observed that...
In this study, we mainly investigated the effects of Shengmai San (SMS) on diabetic cardiomyopathy (DCM) in db/db mice. The mice were randomly divided into model group and SMS group, while C57BLKS/J inbred used as controls. After 24-week treatment, blood glucose, body weight, heart weight determined. Hemodynamic changes left ventricle measured using catheterization. myocardial structure subcellular structural observed by HE staining electron microscopy; myocardium collagen content was...
Abstract Background Trans-cinnamaldehyde (TCA) is one of the main pharmaceutical ingredients Cinnamomum cassia Presl , which has been shown to have therapeutic effects on a variety cardiovascular diseases. This study was carried out characterize and reveal underlying mechanisms protective TCA against cardiac hypertrophy. Methods We used phenylephrine (PE) induce hypertrophy treated with in vivo vitro. In neonatal rat cardiomyocytes (NRCMs), RNA sequencing Kyoto Encyclopedia Genes Genomes...
Cats protract claws while hunting or pawing on the ground and retract to muscles when relaxing. Inspired by this behavior, in order solve problem of short service life low comprehensive drilling efficiency polycrystalline diamond compact bits which results from its poor adaptability soft-hard interbedded strata, a self-adaptive bionic bit was designed, can use elastic element adjust back-rake angle according formation hardness improve bits. Theoretical analysis test show that has strong rock...