A5100616454- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Selenium in Biological Systems
- Healthcare and Venom Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Pharmacogenetics and Drug Metabolism
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Sulfur Compounds in Biology
- Drug Transport and Resistance Mechanisms
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Cardiac Ischemia and Reperfusion
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Autophagy in Disease and Therapy
- Cardiac electrophysiology and arrhythmias
- Computational Drug Discovery Methods
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
Shuguang Hospital
2016-2025
Shanghai University of Traditional Chinese Medicine
2016-2025
Institute of High Energy Physics
2024
Capital Medical University
2016-2024
Beijing Anzhen Hospital
2016-2024
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
Fudan University
2024
Chinese Academy of Sciences
2024
Weatherford College
2024
Background: Hypertension is one of the most challenging public health problems worldwide. Previous studies suggested that Songling Xuemaikang capsule (SXC)—a Chinese herbal formula—was effective for essential hypertension. However, efficacy SXC monotherapy hypertension remains unclear. We aimed to compare blood pressure (BP)–lowering and safety versus losartan in patients with Methods: In this multicenter, randomized, double-blind, noninferiority trial China, 18 65 years age mild were...
Myocardial ischemia/reperfusion injury (MIRI) poses a formidable challenge to cardiac reperfusion therapy due the absence of effective clinical interventions. Methylation N6-methyladenosine (m6A), which is most common post-transcriptional modifications occurring within mammalian mRNA, believed be involved in MIRI by modulating autophagy. MicroRNAs (miRNAs) play crucial role regulating gene expression at level and have been implicated regulation m6A methylation. Suxiao Jiuxin Pill (SJP)...
Medicinal plant extracts have been widely used for cancer treatment. Nitidine chloride (NC) is a natural bioactive alkaloid that has recently reported to diverse anticancer properties. We aimed investigate the cytotoxic effects of NC and effectiveness combinatorial treatment including doxorubicin in breast cells. Using MTT flowcytometry assays, we found induced cell growth inhibition G2/M cycle arrest time- dose-dependent manner both MCF-7 MDA-MB-231 lines. Cancer was associated with...
Many studies have shown effective protection from myocardial ischemia-reperfusion injury (MIRI) in animal models, but few, if any, treatments yielded a substantial reduction clinical. Several showed significant therapeutic effects for the Chinese patent medicine Suxiao Jiuxin Pill (SJP) MIRI, although specific molecular mechanisms remain undefined. Recently, increasing evidence indicates an important role m6A modification autophagy regulation and SJP has not been investigated this regard.In...
Qishen Yiqi dripping pills (QSYQ) may be beneficial in patients with ischaemic heart failure (IHF). We aimed to assess the efficacy and safety of QSYQ administered together guideline-directed medical therapy IHF.This prospective randomized, double-blind, multicentre placebo-controlled study enrolled 640 IHF between March 2012 August 2014. Patients were randomly assigned receive 6 months or placebo addition standard treatment. The primary outcome was min walking distance at months. Among 638...
The purpose of this study is to identify the risk factors for postoperative severe hypoxemia after surgery acute type A aortic dissection.
Dunyeguanxinning (DYGXN) has been shown to have therapeutic effects in preventing and treating atherosclerosis. However, the active components anti- atherosclerosis (AS) mechanisms of DYGXN remain be elucidated. This study aims explore functional prevention treatment (AS). The were identified using UPLC-Q-Orbitrap HRMS technology. Network pharmacology molecular docking utilized core targets DYGXN. An AS mouse model was established verify results obtained from network pharmacology. A total 20...
Background . Shenfu injection (SFI) has shown a remarkable therapeutic effect in patients with chronic heart failure (CHF) during the acute phase of symptom aggravation since it became commercially available 1987. However, SFI not been validated standard clinical study. As pilot trial, this study aimed to evaluate safety and efficacy for treatment CHF phase. Methods A total 160 experiencing were enrolled randomly assigned receive placebo (placebo group, 150 ml glucose (GS)) or (SFI 50 + 100...
Background Recently, evidence from several studies has revealed that air pollution is associated with the increased morbidity and mortality of breast cancer patients. However, to date, underlying mechanism remains largely unclear. Considering high prevalence in China, it necessary understand how may affect cancer. Methods We analyzed 1,832 female patients who had resided same cities for at least 10 years prior their diagnosis. Variables including demographic data as well clinical tumor...
Shengmai injection (SMI), a traditional Chinese herbal medicine extracted from Panax ginseng C.A. Mey., Ophiopogon japonicus (Thunb.) Ker Gawl., and Schisandra chinensis (Turcz.) Baill., has been used to treat acute chronic heart failure. This study aimed further clarify the effects of SMI on energy metabolism. could improve cell-survival rate also reduce myocardial cell hypertrophy apoptosis. Mitochondria are important sites cellular metabolism, protects mitochondrial function which was...
Aim: The Shexiang Baoxin Pill (SBP) has been extensively used to treat cardiovascular diseases in China for four decades, and its clinical efficacy widely approved. However, the mechanism by which this is achieved remains largely unexplored. Research attempting understand underlying ongoing, but findings are controversial. Here, we aimed explore possible of SBP myocardial ischemia-reperfusion (I/R) injury using heart single-nucleus spatial ribonucleic acid (RNA) sequencing. Methods: We...
Abstract Near‐infrared fluorescence ( NIRF ) imaging by using infrared fluorescent protein (i RFP gene labelling is a novel technology with potential value for in vivo applications. In this study, we expressed i mouse cardiac progenitor cells CPC lentiviral vector and demonstrated that the ‐labelled iRFP can be detected flow cytometry microscopy. We observed linear correlation vitro between cell numbers signal intensity multiSpectral system. injected into non‐ischaemic hindlimb were also...
This study evaluated the regulatory effect of Tetramethylpyrazine (TMP) on spinal cord injury (SCI) rat model and clarified neuroprotective mechanism TMP SCI.An SCI was generated treated with injections for two weeks. miR-497-5p EGFL7 expression changes were evaluated, motor function recovery after assessed by BBB score test footprint analysis, lesions HE staining TUNEL staining; angiogenesis immunoblotting CD31; inflammatory factor levels detected ELISA. verified as a target bioinformatics...
Coronary heart disease remains a major global health challenge, with clear need for enhanced early risk assessment. This study aimed to elucidate metabolic signatures across various stages of coronary and develop an effective multiclass diagnostic model. Using metabolomic approaches, gas chromatography–mass liquid chromatography–tandem mass spectrometry were used analyze plasma samples from healthy controls, patients stable angina pectoris, those acute myocardial infarction. Pathway...