A5103079073- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Renal Diseases and Glomerulopathies
- Mitochondrial Function and Pathology
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Vasculitis and related conditions
- Semantic Web and Ontologies
- Autophagy in Disease and Therapy
- Constraint Satisfaction and Optimization
- Inflammasome and immune disorders
- CAR-T cell therapy research
- Traditional Chinese Medicine Analysis
- RNA Research and Splicing
- FOXO transcription factor regulation
- Pharmacological Effects of Natural Compounds
- Multimodal Machine Learning Applications
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- High-Energy Particle Collisions Research
- Cardiac electrophysiology and arrhythmias
- Hippo pathway signaling and YAP/TAZ
- Computational Physics and Python Applications
- AI-based Problem Solving and Planning
- Cardiac Ischemia and Reperfusion
Beijing Children’s Hospital
2019-2024
Capital Medical University
2019-2024
Temple University
2019-2021
Shanghai University of Traditional Chinese Medicine
2016-2019
Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious agents. Therefore, regenerative capacity of alveolar is critical for recovery these insults order to rebuild epithelial barrier and restore pulmonary functions. Here, we show that sublethal infection mice with Streptococcus pneumoniae, most common pathogen community-acquired pneumonia, led exclusive damage lung alveoli, followed by regeneration resolution inflammation. We surfactant protein C–expressing...
In heart failure (HF), energy metabolism pathway in cardiac muscle changes from fatty acid β-oxidation to glycolysis. However, the exact mechanism is unknown. Sarcoendoplasmic reticulum Ca2+α ATPase (SERCA) expression downregulated and mitochondrial function reduced HF, perhaps partly due a substantially supply for excitation-contraction coupling resulting lower rate. We investigated whether Astragaloside IV can activate peroxisome proliferator-activated receptor alpha (PPARα) stimulate...
Background: Autophagy is required for the maintenance of cardiomyocyte homeostasis. However, excessive autophagy plays a maladaptive role in pressure overload-induced heart failure. To identify mechanisms by which Stachydrine inhibits cardiac hypertrophy, we determined inhibitory activities against activation NADPH oxidase, reactive oxygen species(ROS) production and autophagy. Methods: was administered intragastrically to Wistar rats after Transverse aortic constriction(TAC) H9c2 cells were...
Cardiomyocyte proliferation accounts for the increase of cardiac muscle during fetal mammalian heart development. Shortly after birth, cardiomyocyte transits from hyperplasia to hypertrophic growth. Here, we have investigated role fatty acid β-oxidation in and growth early postnatal life mice. A transient wave increased cell cycle activity was observed between day 3 5, that proceeded as maturation. Assessment metabolism neonatal mouse revealed a myocardial metabolic shift glycolysis...
Spatial reasoning is an essential problem in embodied AI research. Efforts to enhance spatial abilities through supplementary data and fine-tuning have proven limited ineffective when addressing complex tasks, largely due their dependence on language-based outputs. While some approaches introduced a point-based action space mitigate this issue, they fall short managing more intricate tasks within environments. This deficiency arises from failure fully exploit the inherent thinking...
Recent advancements in Large Language Models (LLMs) and Vision-Language (VLMs) have made them powerful tools embodied navigation, enabling agents to leverage commonsense spatial reasoning for efficient exploration unfamiliar environments. Existing LLM-based approaches convert global memory, such as semantic or topological maps, into language descriptions guide navigation. While this improves efficiency reduces redundant exploration, the loss of geometric information language-based...
The acute respiratory virus infection can induce uncontrolled inflammatory responses, such as cytokine storm and viral pneumonia, which are the major causes of death in clinical cases. Cyclophilin A (CypA) is mainly distributed cytoplasm resting cells released into extracellular space response to stimuli. Extracellular CypA (eCypA) upregulated promotes severe COVID-19 patients. However, how eCypA virus-induced remains elusive. Here, we observe that induced by influenza B viruses SARS-CoV-2...
Shengmai San (SMS), prepared from Panax ginseng, Ophiopogon japonicus, and Schisandra chinensisin, has been widely used to treat ischemic disease. In this study, we investigated whether SMS may exert a beneficial effect in diabetic cardiomyopathy through improvement of mitochondrial lipid metabolism.A leptin receptor-deficient db/db mouse model was utilized, lean age-matched C57BLKS mice served as non-diabetic controls. Glucose profiles, myocardial structure, dimension, function, heart...
Background: Thermal injury is the main cause of pulmonary disease in stroke after burn and can be life threatening. Heat-induced inflammation an important factor that triggers a series induces pathological changes. However, this mechanism underlying heat-induced thermal inhalation remains unclear. Studies have revealed astragaloside-IV (AS-IV), natural compound extracted from Astragalus membranaceus, has protective effects inflammatory diseases. Here, we investigated whether AS-IV occur...
Heat causes airway damage during inhalation injury because of bronchial epithelial cell damage. Accumulating evidence shows that mitochondrial uniporter (MCU) is involved in We investigated the MCU activity after heat treatment and assessed whether Astragaloside-IV (AS-IV) suppresses heat-induced apoptosis cells by inhibiting activation Ca2+ (MCU), depolarisation reactive oxygen species (ROS) production.The line 16HBE14o- was treated, induced vitro vivo. AS-IV inorganically administered to...
Background/Aims: Skin transplantation aims to cover skin defects but often fails due immune rejection of the transplantated tissue. Immature dendritic cells (imDCs) induce tolerance have a low migration rate. After stimulation, imDCs transform into mature DCs, which activate rejection. Thus, inducing imDC obtain high counteracts development tolerance. Methods & Results: We transfected with recombinant adenovirus carrying CCR7 gene (Ad-CCR7) and small interfering RNA targeting RelB...
Previous research has shown that microRNA 506 (miR-506) functions as an essential modulator in the development of many biological reactions, including multiple cancers. However, its involvement cutaneous squamous cell carcinoma (CSCC) been rarely reported. In present work, we investigated molecular mechanism and function miR-506 regulation CSCC viability metastasis (migration invasion). We observed expression was upregulated both tissues lines, decreased led to repressed tumorigenesis cells....
In this study, we mainly investigated the effects of Shengmai San (SMS) on diabetic cardiomyopathy (DCM) in db/db mice. The mice were randomly divided into model group and SMS group, while C57BLKS/J inbred used as controls. After 24-week treatment, blood glucose, body weight, heart weight determined. Hemodynamic changes left ventricle measured using catheterization. myocardial structure subcellular structural observed by HE staining electron microscopy; myocardium collagen content was...
Recent advancements in Large Language Models (LLMs) have spurred numerous attempts to apply these technologies embodied tasks, particularly focusing on high-level task planning and decomposition. To further explore this area, we introduce a new benchmark, ET-Plan-Bench, which specifically targets using LLMs. It features controllable diverse set of tasks varying different levels difficulties complexities, is designed evaluate two critical dimensions LLMs' application understanding: spatial...
Patients with lupus nephritis (LN) typically undergo long-term treatment glucocorticoids (GCs) and immunosuppressants. There is a growing demand for optimal therapy better remission results fewer side effects. Sustained traditional Chinese medicine (TCM) might be quite valuable multitarget therapy, reducing the total dosage of GCs minimizing effects immunosuppressants.To evaluate whether Dan Bai Xiao Formula (DBXF) can reduce exposure to cyclophosphamide (CYC) assess efficacy safety DBXF...
Abstract Background Cardiomyocytes proliferate rapidly during fetal life but lose their ability of proliferation soon after birth. However, before terminal withdrawal from the cell cycle, cardiomyocytes undergo another round cycle early postnatal in mice. While a transient wave increased DNA synthesis cardiomyocyte has been observed mouse hearts, molecular mechanisms describing re-entry remain poorly understood. Atrial and B-type natriuretic peptides (ANP BNP) are abundantly expressed...
Recurrence is considered a vital problem for assessing the prognosis of Henoch-Schonlein purpura (HSP). The objective this study was to evaluate factors affecting recurrence in children with HSP.We retrospectively reviewed records 368 patients under age 16 years diagnosed HSP from October 2019 December 2020 Beijing Children's Hospital. Patients were divided into non-recurrence group and according whether there recurrence. Incidence manifestation, possible cause, age, treatment analyzed....
To study the association of animal protein diet with recurrence Henoch-Schönlein purpura (HSP)/skin rash and risk factors for HSP.A prospective analysis was performed 121 children HSP who were admitted to Beijing Children's Hospital from October December 2020. The given doctor's advice same (animal could be added after 1 week without new-onset skin rash). Follow-up at outpatient service half a year. According presence or absence intake, divided into an observation group 65 control 56...