A5100386098- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Studies on Chitinases and Chitosanases
- Ubiquitin and proteasome pathways
- Lipid metabolism and disorders
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Alzheimer's disease research and treatments
- Cannabis and Cannabinoid Research
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- Lipid metabolism and biosynthesis
- Bioactive natural compounds
- Neurological Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA modifications and cancer
- Pancreatic function and diabetes
- Bone Tumor Diagnosis and Treatments
- Neonatal and fetal brain pathology
First Hospital of Lanzhou University
2023-2025
Lanzhou University
2023-2025
Chinese Institute for Brain Research
2022
Capital Medical University
2020-2022
Nanjing Medical University
2021-2022
Beijing YouAn Hospital
2022
Zhongnan Hospital of Wuhan University
2020
Wuhan University
2020
Beijing Institute of Neurosurgery
2020
Fudan University
2019
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease, the pathological process of which complex. Activation c‑Jun N‑terminal kinase (JNK) signaling pathway associated with mechanism underlying obesity-induced insulin resistance. Furthermore, JNK and dysfunctional autophagy serve important roles in hepatic lipid metabolism. However, exact role obesity‑induced resistance not fully understood. Therefore, present study aimed to investigate mechanisms by regulates liver. A rat...
Whether changes in internal body environment affect kidney aging remains unclear. Specifically, it is unknown whether transplanted kidneys from older donors recover tissue damage after placement younger recipients. In this study, a parabiosis animal model was established to investigate the effects of young on aged kidneys. The animals were divided into six groups: (Ycon) and old control (Ocon) groups, isochronic youth-youth group (Y-IP), elderly-elderly (O-IP), heterochronic youth (Y-HP)...
Cuproptosis is a newly identified form of cell death that relies on copper (Cu) ionophores to transport Cu into cancer cells. As perennial herb, Patrinia scabiosaefolia Fisch (PS) has garnered significant attention owing its analgesic, anti-inflammatory, antibacterial, and antitumor properties. Previous research shown the extract from PS (DEPS) can inhibit growth leukemia lines. However, specific mechanism anti-leukemic effect not been fully clarified. Therefore, this study was conducted...
Acquisition of anoikis resistance is the hallmark cancer and has been shown to be involved in metastasis melignant cells. Our previous work showed that associated with hepatocellular carcinoma (HCC) The aim this study elucidate mechanisms course.Expression BNIP3 HIF-1α at mRNA protein level HCC cells were detected by realtime PCR western blot, respectively. Autophagy activation signaling transduction pathway blot. Cell viabilities CCK8 assay trypan blue exclusion assay.Upregulation promoted...
Autophagy plays a vital role in cancer initiation, malignant progression, and resistance to treatment; however, autophagy-related gene sets have rarely been analyzed glioblastoma. The purpose of this study was evaluate the prognostic significance genes patients with glioblastoma.Here, we collected whole transcriptome expression data from Chinese Glioma Genome Atlas (CGGA) Cancer (TCGA) datasets explore relationship between glioblastoma prognosis. R language primary analysis drawing tool.We...
Clinical implications of the BRCA2 expression level on treatments ovarian cancer are controversial. Here, we demonstrated that platinum-resistant had a higher percentage high (87.5% vs 43.6%, P = 0.001), and patients with low in tissues longer progression-free survival (with median time 28.0 12.0 months, < 0.001) platinum-free duration 19.0 5.0 compared those level. In human cell lines CAOV-3 ES-2, cisplatin induced an upregulation RAD51 protein, which was inhibited after silencing ;...
Background: Thermal injury is the main cause of pulmonary disease in stroke after burn and can be life threatening. Heat-induced inflammation an important factor that triggers a series induces pathological changes. However, this mechanism underlying heat-induced thermal inhalation remains unclear. Studies have revealed astragaloside-IV (AS-IV), natural compound extracted from Astragalus membranaceus, has protective effects inflammatory diseases. Here, we investigated whether AS-IV occur...
Background: Though ASPP2 plays an important role in regulating cell apoptosis and autophagy case of liver injury, there remains a lack clarity on the molecular mechanism apoptosis. Methods: A hepatocyte injury model was constructed using HL7702 line TNF-α. The cells were treated by overexpression adenovirus or short hairpin RNA lentivirus endoplasmic reticulum stress (ERS) mammalian target rapamycin (mTOR) inhibitor agonist, respectively. detected means western blot Green fluorescent...
Objectives . We investigated the role of cardiomyocyte autophagy and its regulatory mechanisms by WenxinKeli (WXKL) in cells subjected to hypertrophy. Methods H9C2 cardiomyocytes were divided into 8 groups. Cytoskeletal proteins as well endogenously expressed marker studied confocal imaging. Western blotting was used assess levels light chain‐3 (LC3) mechanistic target rapamycin (mTOR). The cell viability assay detect content ATP. Flow cytometry apoptotic cardiomyocytes. Results (1) Compared...
Background and Aims The heat shock protein (Hsp) 90α is induced by stress regulates inflammation through multiple pathways. Elevated serum Hsp90α had been found in nonalcoholic steatohepatitis (NASH). Geranylgeranylacetone (GGA, also called teprenone) a terpenoid derivative. It was reported to induce Hsp alleviate insulin resistance. We aimed evaluate the as biomarker predicting metabolic-associated fatty liver disease (MAFLD) define therapeutic effects of geranylgeranylacetone for disease....
As a high fatal disease, fat embolism syndrome is complication, which brought great pain to patient and their family served as serious social burden. The mechanism of FES remains unclear. Autophagy controls the cell survival homeostasis by removing mis-folded proteins damaged organelles well intracellular pathogens through lysosomal degradation pathway. Increasing research documented that autophagy was wildly involved in variety human diseases had huge therapeutic potential. In our study, we...
Nix (NIP3-like protein X, BNIP3L), a hypoxia-responsive member of the Bcl-2 family proteins, is believed to play key roles in both hypoxia-mediated cell death and mitophagy. Because our previous work demonstrated that hypoxia, potentially stressful condition, promotes preferential expansion GBM stem-like cells HIF-1-dependent mechanism, we investigated GBM. We observed elevated levels mitochondrial LC3B-II/I ratio tissues. Series experiments revealed but not BNIP3, mediated hypoxia-induced...
Abstract Patrinia scabiosaefolia Fisch (PS), a perennial herb belonging to the genus Pinus in family Pinnacle Sauce, has been previously known for its analgesic, anti‐inflammatory, antibacterial, and antitumor properties. However, specific mechanism behind antileukemic effect remains unknown. This study focused on cytotoxicity potential modes of action dichloromethane extract from PS (DEPS) acute myeloid leukemia (AML) cells. Our results demonstrated that DEPS reduced cell viability,...
Objective To investigate and analyze serological hepatic morphological changes in aged rats with non-alcoholic fatty liver disease(NAFLD)by establishing NAFLD model SD at different months of age. Methods Male were randomly divided into four groups according to age: the group(18-months-old), control young group(2-months-old)and group(2-months-old), 12 each group.Rats fed a 45% high-fat diet normal diet, respectively, for eight weeks.Serum biochemical indexes insulin index...
OBJECTIVE To investigate whether icariin (ICA), a flavonoid extracted from the Chinese herb ( Berberidaceae epimedium L), can ameliorate learning and memory function via improving cerebral glucose metabolism disorder in APP/PS1/Tau triple transgenic Alzheimer's disease mice (3×Tg‐AD mice). METHODS Three‐month‐old male 3×Tg‐AD were randomly divided into three groups (n=10 per group): 3×Tg group, + ICA 30 mg/kg 60 age‐matched wild type (WT) two WT control WT+ group. vehicle (0.5% Tween‐80...
Background: Obesity and nonalcoholic fatty liver disease are strongly associated with type 2 diabetes mellitus (T2DM), affecting insulin sensitivity β-cell function. They interact, exacerbating the development of hyperinsulinemia to T2DM. Methods: Through oral glucose tolerance secretion tests, relationships between secretion, clearance, body mass index (BMI), were studied in newly diagnosed T2DM patients. The homeostasis model assessment resistance (HOMA-IR), function (HOMA-β), (ISI),...
Abstract Backgrounds. The cellular homeostasis is major maintained by the catabolic pathway of autophagy. Our previous work indicated that SWCNH were associated with endoplasmic reticulum (ER) stress mediated calcium flow and autophagic response. But, its mechanism was unclear. Methods . regulation on then autophagy liver cells investigated through inducing ER tunicamycin SWCNH. calcuim determined using Fluo-3, examined immunofluorescence or western blot for LC3, Beclin-1, ATG-5, p62....