A5047073949- Dialysis and Renal Disease Management
- Inflammatory Biomarkers in Disease Prognosis
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Circular RNAs in diseases
- Muscle and Compartmental Disorders
- Potassium and Related Disorders
- Lipoproteins and Cardiovascular Health
- Folate and B Vitamins Research
- Peripheral Artery Disease Management
- Central Venous Catheters and Hemodialysis
- Parathyroid Disorders and Treatments
- Cancer Mechanisms and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gout, Hyperuricemia, Uric Acid
- Chronic Disease Management Strategies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nuclear Receptors and Signaling
- Case Reports on Hematomas
- Iron Metabolism and Disorders
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Renal Diseases and Glomerulopathies
- Magnesium in Health and Disease
Southern Medical University
2015-2025
Zhujiang Hospital
2015-2025
Vanderbilt University Medical Center
2024
Chengdu University of Traditional Chinese Medicine
2023
The First Affiliated Hospital, Sun Yat-sen University
2013-2022
Sun Yat-sen University
2013-2022
Guangzhou Medical University
2020
Nanchang University
2020
Shanghai Jiao Tong University
2020
Bridge University
2020
Diabetic nephropathy (DN), a vascular complication of diabetes, is the leading cause death in patients with diabetes. The contribution aberrantly expressed circular RNAs (circRNAs) to DN vivo poorly understood. Integrated comparative circRNA microarray profiling was used examine expression circRNAs diabetic kidney db/db mice. We found that circRNA_010383 markedly downregulated kidneys, mesangial cells, and tubular epithelial cells cultured high-glucose conditions. colocalized miRNA-135a...
Diabetic nephropathy (DN), a vascular complication of diabetes mellitus, is the leading cause death in diabetic patients. The contribution aberrantly expressed circRNAs to
Background Immune-inflammatory biomarkers (IIBs) have been shown to be correlated with prognosis in patients undergoing peritoneal dialysis (PD). In this study, we aimed evaluate the relationship between a novel comprehensive biomarker, pan-immune-inflammation value (PIV), and of PD.Methods We retrospectively analyzed data from multicenter, large-sample PD database. PIV was calculated as (neutrophil count × platelet monocyte count)/lymphocyte count. The prognostic endpoints study were...
Apoptosis, one of the major causes podocyte loss, has been reported to have a vital role in diabetic nephropathy (DN) pathogenesis, and understanding mechanisms underlying regulation apoptosis is crucial. Metadherin (MTDH) an important oncogene, which overexpressed most cancers responsible for apoptosis, metastasis, poor patient survival. Here we show that expression levels Mtdh phosphorylated p38 mitogen-activated protein kinase (MAPK) are significantly increased, whereas those microRNA-30...
Abstract Although accelerated cellular senescence is closely related to the progression of chronic kidney disease (CKD) and renal fibrosis, underlying mechanisms remain largely unknown. Here, we reported that tubular aberrant expression Brahma-related gene 1 (BRG1), an enzymatic subunit SWItch/Sucrose Non-Fermentable complex, critically involved in fibrosis. BRG1 was significantly up-regulated kidneys, predominantly epithelial cells, both CKD patients unilateral ureteral obstruction (UUO)...
The monocyte-to-lymphocyte ratio (MLR), as a new marker of the systemic inflammatory response, is associated with cardiovascular disease (CVD) mortality in general population and hemodialysis patients. However, association between MLR CVD peritoneal dialysis (PD) has received little attention.In this multicenter retrospective cohort study, 1753 incident PD patients from November 1, 2005, to June 30, 2017, baseline were enrolled. primary endpoint was mortality. assessed using...
In individuals receiving continuous ambulatory peritoneal dialysis (CAPD), remnant cholesterol (RC) and high-density lipoprotein (HDL-C) levels significantly influence clinical outcomes. Current practice might benefit from assessing these two lipid markers in combination when evaluating cardiovascular disease (CVD) all-cause mortality. Therefore, this research sought to examine how the RC/HDL-C ratio correlates with both CVD mortality rates among CAPD treatment. Between January 1, 2005...
Background: Clonal hematopoiesis of indeterminate potential (CHIP) is a common inflammatory condition aging that causes myriad end-organ damage. CHIP has been associated with incident AKI and kidney function decline in the general population, particularly mutations genes other than DNMT3A (termed non- CHIP). Prior studies individuals CKD had limited sample sizes conflicting findings. Methods: We examined progression four cohorts (N = 5,654): Chronic Renal Insufficiency Cohort (CRIC), African...
Objective Malnutrition and inflammation are associated with mortality in peritoneal dialysis (PD) patients. Serum albumin non-high-density lipoprotein cholesterol (non-HDL-C) independently PD Combining non-HDL-C may be more plausible clinical practice.
Abstract An imbalance in the serum sodium to chloride ratio (Na/Cl) was linked higher mortality among heart failure patients. Nonetheless, prognostic significance of Na/Cl individuals undergoing peritoneal dialysis (PD) remains unexplored. This study seeks explore association between initial levels and PD The study, conducted across multiple centers, included 3341 patients from January 1, 2005, December 31, 2021. Patients were stratified into quartiles according baseline followed up for a...
Prior studies have shown that the levels of some platelet (PLT) indices were associated with mortality in patients undergoing hemodialysis. We aimed to investigate whether changes PLT on peritoneal dialysis (PD). A single-center, retrospective observational cohort study was conducted incident PD from 1 January 2006 31 December 2012, and followed up until 2014. Cox proportional hazard models used examine relationships between including PLT, plateletcrit (PCT), mean volume (MPV), distribution...
Micheliolide (MCL), derived from parthenolide (PTL), is known for its antioxidant and anti-inflammatory effects has multiple roles in inflammatory diseases tumours. To investigate effect on renal disease, we intragastrically administrated DMAMCL, a dimethylamino Michael adduct of MCL vivo use, two fibrosis models–the unilateral ureteral occlusion (UUO) model an ischaemia-reperfusion injury (IRI) used combination with transforming growth factor beta 1 (TGF-β1) mouse tubular epithelial cells...
Podocyte injury is the primary cause of glomerular in diabetic nephropathy (DN). Advanced oxidation protein products (AOPPs), triggers and markers oxidative stress DN, have been linked to podocyte damage. However, underlying mechanism not yet clear. Here, we investigated potential role FOXO3a, a key transcription factor response stress, mediating AOPPs-induced injury. We found that FOXO3a expression was increased glomeruli kidney biopsies from patients with DN it positively correlated...
Atherosclerosis, the main cause of cardiovascular disease (CVD), is prevalent in patients undergoing peritoneal dialysis (PD). Atherogenic index (AI) a strong predictor atherosclerosis. However, its prognostic value CVD outcomes and all-cause mortality among PD remains uncertain. Therefore, we aimed to evaluate association between AI patients.Calculated based on lipid profiles obtained through standard laboratory procedures, was evaluated 2682 who underwent therapy January 2006 December 2017...