A5100712822- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Immunotherapy and Immune Responses
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Herpesvirus Infections and Treatments
- Receptor Mechanisms and Signaling
- CAR-T cell therapy research
- Dialysis and Renal Disease Management
- Gestational Diabetes Research and Management
- Cancer Research and Treatments
- Bone health and treatments
- Child Nutrition and Water Access
- Pregnancy-related medical research
- Tuberculosis Research and Epidemiology
- Psoriasis: Treatment and Pathogenesis
- Mass Spectrometry Techniques and Applications
- Proteoglycans and glycosaminoglycans research
- Nutritional Studies and Diet
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Calcium signaling and nucleotide metabolism
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Genomics, phytochemicals, and oxidative stress
Sir Run Run Shaw Hospital
2025
Zhejiang University
2025
National Institute of Biological Sciences, Beijing
2022-2025
Tsinghua University
2025
First Affiliated Hospital of Hebei Medical University
2024
Jimei University
2024
Hebei Medical University
2024
Wuhan University
2021-2024
Hubei Provincial Center for Disease Control and Prevention
2024
China Pharmaceutical University
2024
Background and purposeTo compare 68Ga-fibroblast activation protein inhibitor (FAPI) 18F-FDG PET/CT in imaging locally advanced oesophageal cancer, evaluate the potential usefulness of 68Ga-FAPI on gross target volume (GTV) delineation aimed at radiotherapy planning for cancer as compared with contrast-enhanced CT (CE-CT) PET/CT.Materials methodsTwenty-one patients newly diagnosed who underwent both scans were selected. GTVs primary tumours based CE-CT (GTVCT), PET/CT, plus delineated. Gross...
Glioblastoma (GBM) is an aggressive brain cancer that highly resistant to treatment including chimeric antigen receptor (CAR)-T cells. Tumor-associated microglia and macrophages (TAMs) are major contributors the immunosuppressive GBM microenvironment, which promotes tumor progression resistance. Hence, modulation of TAMs a promising strategy for improving immunotherapeutic efficacy CAR-T cells against GBM. Molecularly targeting drug pexidartinib (PLX) has been reported re-educate toward...
Stromal cell-derived factor 1 (SDF-1) is a critical regulator of endothelial progenitor cells (EPCs) mediated physiological and pathologic angiogenesis. It was considered to act via its unique receptor CXCR4 for long time. CXCR7 second, recently identified SDF-1, role in human EPCs unclear. In present study, found be scarcely expressed on the surface derived from cord blood, but considerable intracellular detected, which differs that rat bone marrow. failed support SDF-1 induced migration,...
Prenatal adverse environments can cause fetal intrauterine growth retardation (IUGR) and higher susceptibility to multiple diseases after birth, related multi-organ development programming changes mediated by overexposure maternal glucocorticoids. As a glucocorticoid barrier, P-glycoprotein (P-gp) is highly expressed in placental syncytiotrophoblasts; however, the effect of P-gp on occurrence IUGR remains unclear.Human placenta cord blood samples fetuses were collected, indexes detected....
Axon degeneration, driven by the NAD + hydrolyzing enzyme SARM1, is an early pathological hallmark of numerous neurodegenerative diseases. SARM1 exists in inactive form and activated following nerve injury. However, precise molecular mechanism underlying activation remains to be fully elucidated. In this study, we report identification a potent proactivator G10, which converted into direct activator (M1) nicotinamide phosphoribosyltransferase. Cryoelectron microscopy structures bound M1, as...
Due to multidimensional complexity of solid tumor, development rational T-cell combinations and corresponding formulations is still challenging. Herein, a triple combination T cells are developed with Indoleamine 2,3-dioxygenase inhibitors (IDOi) Cyclin-dependent kinase 4/6 (CDK4/6i). To maximize synergism, spatiotemporally controlled engineering technology formulate drugs into one cell therapeutic, established. Specifically, sequentially responsive core-shell nanoparticle (SRN)...
In mammals, bile acid (BA) concentrations are regulated largely by the gut microbiota, and a study has shown that some metabolic responses to microbiota conserved between zebrafish mice. However, it remains unknown whether influence of specific intestinal microbes on BA metabolism is higher lower vertebrates (i.e., mammals fish). present study, Citrobacter freundii GC01 isolated from grass carp (Ctenopharyngodon idella) intestine was supplemented fish mice feed. We found changes in profile,...
Abstract Abnormal expression levels of miRNA are associated with various tumor diseases, for example, glioma tumors characterized by the up-regulation miRNA-182. Surface plasmon resonance (SPR) assay miRNA-182 from patients was performed via DNA walking amplification strategy. The duplex between aminated swing arm (swDNA) and block (blDNA), track (trDNA) a biotin tag were tethered on poly(ethylene glycol) (PEG)-modified chips. Upon formation miRNA/blDNA duplex, SPR signal decreased process...
Limited studies have examined the associations between diet quality and gestational weight gain (GWG) among Chinese pregnant women, adopting GWG guidelines. We prospectively investigate of quality, using Healthy Diet Index for Pregnancy (CHDI-P), which assessed from 'Diversity', 'Adequacy' 'Limitation' dimensions with overall 100 points, participants enroled in Southwest China. Food consumption was collected by 24 h dietary recalls three consecutive days CHDI-P scores were divided into...
Intrauterine growth restriction (IUGR) is a common perinatal complication in animal reproduction, with long-lasting negative effects on neonates and postnatal animals, which seriously negatively affects livestock production. In this study, we aimed to identify potential genes associated the diagnosis of IUGR through bioinformatics analysis. Based 73 differentially expressed related obtained by differential analysis weighted gene co-expression network analysis, used three machine learning...
Background/aim: This study aimed to the effect of pretreatment transcutaneous electrical acupoint stimulation (TEAS) in preventing propofol injection-related pain. Materials and methods: A total 360 patients who were undergo elective hysteroscopy surgery randomly divided into following three groups 120 each: control (Group C), sham TEAS F), T). Patients Group C did not any treatment before surgery; 30 min induction anesthesia, Groups F T underwent bilateral LI4-PC6 acupoint. subjected...
Purpose: To determine the characteristics of acute pain after laparoscopic-assisted vaginal hysterectomy (LAVH), laparoscopic myomectomy (LM), and adnexectomy (LA) compare them with each other. Patients Methods: undergoing LAVH, LM, LA under general anaesthesia at First Affiliated Hospital Wenzhou Medical University between December 2017 2019 were selected. Their data collected before, during, surgery. We evaluated degrees in group patients compared them. Results: There differences baseline...
Osteoclastic resorption of bones plays a central role in both osteoporosis and bone metastasis. A reliable vitro assay that simulates osteoclastic vivo would significantly speed up the process developing effective therapeutic solutions for those diseases. Here, we reported development novel robust nanostructured calcium phosphate coating with unique functions on track-etched porous membrane by using an ammonia-induced mineralization (AiM) technique. The uniformly covers one side PET...
To examine the association between fruit intake and blood glucose metabolism.Healthy singleton pregnant women with 6-14 weeks of gestation were selected in a maternal-and-child health care institution Chengdu from February to July 2017. Dietary information was obtained by 3-day 24-hour dietary recall during each trimester, average daily total per person calculated. According guidelines for Chinese women(2016), insufficient rates fruits calculated, participants divided into group, suitable...
Fetal-originated diseases refer to birth defects of offspring and multiple chronic in adulthood caused by abnormal embryonic development. However, due the vulnerability fetus/ neonate technical limitations, it is very difficult carry out effective development assessment early warning long-term stages life. It known that placenta unique link between mother fetus, its role occurrence progression fetal-originated cannot be ignored. Studies have found a variety adverse environmental factors...
Tumor necrosis factor receptor superfamily 25 (TNFRSF25) is a T-cell co-stimulatory receptor. Expression of its ligand, TNF-like cytokine 1A (TL1A), on mouse tumor cells has been shown to promote regression. This study aimed develop TNFRSF25 agonists (both antibodies (Abs) and TL1A proteins) investigate their potential antitumor effects.
<title>Abstract</title> Objects: Melanoma (malignant melanoma, MM) is a highly aggressive tumor, ranking as the third most common cutaneous malignancy, characterized by high metastatic potential, mortality, and poor prognosis. Solanine major steroidal alkaloid found in potatoes, its anticancer benefits have been widely reported. However, inhibitory effects on melanoma cells less studied. The aim of this study was to observe solanine proliferation, apoptosis related apoptotic proteins A375...
SIFamide is an amidated neuropeptide with a conserved Ser-Ile-Phe structure at its C-terminal, which crucial in insect courtship, sleep and feeding insects. However, little information exists regarding function crustaceans. This study aimed to identify the cDNA of Sp-SIFa two putative receptors ( Sp-SIFaR1 Sp-SIFaR2 ) mud crab Scylla paramamosain . The expression profiles signaling were investigated explore their potential roles. results indicated that was expressed primarily nervous tissues...
A quantitative method was developed for the direct identity confirmation and quantification of alendronate using CE-MS combined with a pH-assisted focusing technique, dynamic pH barrage junction focusing. pH-induced variation in electrophoretic mobility led to online at sample/pH boundary, significantly improving detection sensitivity. In addition, use flow-through microvial CE electrospray interface multiple reaction monitoring mode MS further improved specificity capability this...
Acute kidney injury (AKI) is a severe and frequent complication of sepsis that occurs in intensive care units with inflammation rapid decline renal function as the main pathological features. Systemic inflammation, microvascular dysfunction, tubule are causes sepsis-induced AKI (SI-AKI). The high prevalence death rate from SI-AKI great challenge for clinical treatment worldwide. However, addition to hemodialysis, there no effective drug improve tissue damage alleviate function. We conducted...