Purpose: Cymbopogon nardus (L). Rendle has traditionally been recognized for its medicinal properties. Recent studies have suggested that bioactive constituents possess antioxidant and anti-inflammatory However, there is limited scientific evidence of cellular effects. Given the pathogenesis many diseases involves oxidative stress inflammation, this study aimed to evaluate potential effects plant extracts in 3T3-L1 cells. Methods: Phytochemical screening C. was performed identify compounds....

There are numerous medicinal benefits from herbal plants, with many medicines being used as 'Jamu', 'standardized medicines' and phytopharmaceuticals.

Forty-eight male Wistar rats were divided into anti-inflammatory mechanism study (n = 18) and acute toxicity 30). The employed six groups 3), e.g., the normal control, negative positive control (quercetin 20 mg/kg BW), three doses of BREE (250 BW; 500 1000 BW). All (except control) inflammatory-induced i.p. using 0.1 mL 1% acetic acid. expression Akt NF-kappaB p65 in stomach intestine was examined Western blot analysis. (21 days) conducted by following Regulation Indonesia National Agency...

Foot and mouth disease (FMD) is a widespread infectious that significantly affects the dairy farming sector in Indonesia. In reducing impact caused by FMD, proper treatment performed veterinarians necessary. Hematological profile can be used as data reference to prioritize cattle infected with FMD. This study aimed describe hematological FMD infection. was collected from 15 infection at Koperasi Peternak Sapi Bandung Utara (KPSBU), Lembang, West Bandung, Java, Parameters observed hematology...

Chronic exposure to elevated levels of pro-oxidant factors may cause structural failings at the mitochondrial DNA level and alteration antioxidant enzymes (glutathione peroxidase, catalase, superoxide dismutase). Oxidative stress is an imbalance between capacity endogenous non-enzymatic antioxidants (glutathione, alpha-lipoic acid, uric ferritin, metallothionein, melatonin, bilirubin) occurrence which lead pathogenesis various diseases that affects kidneys, pancreas, central nervous system,...

The global incidence of recurrent aphthous stomatitis in 2018 reached 5–66 % the population, while Indonesia 8 %. Moreover, prevalence oral mucosal fibrosis and among male doctors nurses China was 21.24 24.27 %, respectively. Our previous study has shown that ethanol extract Kaempferia galanga L. rhizome (EKGR) revealed an accelerated wound-healing effect mucosa ulcer Wistar rats. This aims to explore effects EKGR on expression NF-kappaB-p65 COX-2 tongue tissue rats by Western blot analysis...

BACKGROUND: Age contributes to body composition alteration, rises a common disorder in elderly known as sarcopenic obesity (SO), which is characterized by the combination of (excess fat mass) and sarcopenia (reduced skeletal muscle clinical form function.CONTENT: The primary cause SO insulin resistance. Glucose transporter 4 (GLUT4) dysfunction results impaired fatty acids oxidation. Decreased mass lower mitochondria number volume. Both will increase oxidative stress. Together with altered...

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Nitric oxide synthases (NOSs) are enzymes that function by generating nitric (NO) from its substrate, L‑arginine, in human tissues. There three known isoforms of NOS, eNOS (endothelial NOS), nNOS (neuronal and iNOS (inducible NOS). is released response to inflammation. The inhibitor, S‑ethylisothiourea (SEITU), has been found attach a Glu377 residue within the active‑site cavity enzyme. discovery inhibitors always challenging. <em>Boesenbergia rotunda</em> (<em>B. rotunda</em>) reported...

Flavonols in plants are catalyzed by flavonol synthase (FLS) enzyme. FLS was reported expressed flowers and fruits, i.e., Dianthus caryophyllus L. (Caryophyllaceae), Petunia hybrida Hort. (Solanaceae), Arabidopsis thaliana (Brassicaceae), Citrus unshiu Marc. (Rutaceae). However, none about medicinal plants, particularly those which possess anti-inflammatory activity. This study aimed to extract identify the rhizome of Boesenbergia rotunda (Zingiberaceae) determine quercetin ethanol...

Antifibrotic candidates of Selenium nanoparticles and selenium in the experimental modelAziza B. Shalby, Mohamed Diaa Abd El-Maksoud, Ahmed E. Abdel Moneim, Hanaa H.

An increasing percentage of people have or are at risk to develop the non-alcoholic fatty liver disease (NAFLD) worldwide. Fibrosis has also been identified as most important predictor prognosis in patients with NAFLD. Ciplukan (Physalis angulata Linn.) was reported antifibrotic potency CCl4-induced fibrotic rats. This study conducted evaluate effect ciplukan extract through repairing function, anti-inflammatory, and lowering cholesterol. The fibrosis model using 20% margarine injected...

Fitness becomes an important benchmark for public health in every age group. Activities with poor adverse fitness are at risk of injury. Good is gained from a balance everyday physical activity conditions that free metabolic syndrome. This study investigated the relationship activity, energy balance, and syndrome to 166 professors Universitas Padjadjaran who underwent 1-month checkup BAPELKES Bandung period 2017. Based on regression analysis, results showed significant between elderly group...

Coccidiosis is a parasitic disease that causes economic losses on chicken farms. A case was found farm in Rancaekek, Bandung Regency, where there one-year-old laying hen stopped producing eggs, experienced decreased pectoral muscle mass, and had mild ataxia. The diagnosis made by necropsy procedure fecal examination. There were lesions the small intestine, these manifested as ballooning filled with orange mucus presence of petechial hemorrhages luminal wall mass found. Fecal examination...

Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, natural abilities in various metabolic and inflammatory diseases. This study aims determine the of ethyl acetate fraction P. NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, histopathological features, which are methods evaluate course potential effect.Method: research is an...

Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, natural abilities in various metabolic and inflammatory diseases. This study aims determine the of ethyl acetate fraction P. NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, histopathological features, which are methods evaluate course potential effect.Method: research is an...

Cisplatin is a platinum-based anticancer drug that, in long-term use, causes nephrotoxicity due to oxidative stress and increases total cholesterol triglycerides animal models. Angelica keiskei (Miq.) Koidz., (A. keiskei) or Japanese celery ashitaba, has been reported for its antioxidant nephroprotective activity. This study aims determine the activity of A. sap on levels cisplatin-induced Wistar rats. The keiskeiwas freeze-dried until yield 3.62% w/v was obtained. fat content powder...

&lt;b&gt;Background and Objective:&lt;/b&gt; Malnutrition stunting are major unresolved problems in Indonesia. Protein deficiency can cause stunted growth, as well make physical cognitive abilities cannot reach their maximum potential. During childhood the need for protein must be fulfilled so that peak of bone formation during adolescence perfect. In malnourished children, a low diet will lead to thinning cortex. Due high rate malnutrition children due deficiency, study was conducted on...

Abstract. Withaningsih S, Ilham MF, Rosdianto AM. 2024. Morphometric and DNA sexing accurately in male Javan hawk-eagle (Nisaetus bartelsi) determination at Kamojang Eagle Conservation Center, West Java, Indonesia. Biodiversitas 25: 1167-1173. The is a protected endemic species of eagle Indonesia whose existence symbolized by the Garuda Pancasila. Raptors act top predatory chain as indicators environmental health. IUCN data states that N. bartelsi red-listed endangered. It one Indonesia's...

Pulmonary fibrosis is a fatal lung disease with unknown pathogenesis and limited treatment options. Herbal medicine began to be developed as an antifibrosis drug for this disease. Ciplukan plant (Physalis angulata Linn.), wild that has been widely used generations traditional Indonesian various diseases; but never studied antifibrosis. This study aimed determine herb ethanol extract (CPL) bioactivity in pulmonary disorders experimental mice model induced by bleomycin. A total of 35 male...

Abstract The endocrine system is critical for adapting to malnutrition, which can disrupt the pituitary-liver axis and induce inflammation, leading health complications. Lima beans ( Phaseolus lunatus L.), known their high protein content anti-inflammatory properties, present a potential nutritional intervention. This study investigated effects of lima bean powder on regulation activity in malnourished rats. Rats were divided into four groups: Normal (N), Malnourished (MAL), MAL treated with...

Sedentary lifestyle can cause the accumulation of energy reserves in form lipids white adipose cells. Lifestyle modification by means exercise is done to reduce fat tissue (WAT). This study aims determine effect various intensities on histological changes Research method exploratory with Federer formula number samples carried out. Using 28 Wistar rats located at Central Laboratory Padjadjran University, Sumedang from May June 2022. The data taken were average diameter ± standard error (SEM)...