This study aims to provide new insights into the potential of oyster mushroom (Pleurotus ostreatus) ethanolic extract in preventing obesity through inhibition Pparg expression and modulation methylation level on promoter during 3T3-L1 adipocyte differentiation. vitro quantitative experimental was conducted by treating cell line differentiated using 0.5 mM methyl-isobutyl-xanthine, 1 μM dexamethasone, 10 μg/mL insulin-containing medium with extract. The obtained from 80 g dried powder...

Excessive adipogenesis plays a role in the development of obesity and related metabolic disorders. Aaptamine is an alkaloid compound that has been proven to have various effects, however, no studies yet investigated its effects on adipogenesis. This study aims examine whether aaptamine inhibits lipid accumulation Pparg Slc2a4, two important genes adipogenesis, mRNA expression, increases methylation promoter. strengthens insights regarding these regulation, with future research potentially...

The sarcopenic phenotype is characterized by a reduction of muscle mass, shift in fiber-type distribution, and reduced satellite cell regeneration. Sarcopenia still major challenge to healthy aging. Traditional Indonesian societies Sulawesi island have been using nutmeg for maintaining health condition during Interestingly, has known stimulate peroxisome proliferator activated receptors γ (PPARγ) which may contribute myogenesis process cardiac muscle. There limited information about the role...

BACKGROUND Melanoma is one of the most aggressive types cancer and it has shown a remarkable surge in incidence during last 50 years. been projected to be continuously rising future. Therapy for advanced-type melanoma still challenge due low response rate poor 10-year survival. Interestingly, several epidemiological preclinical studies had reported that vitamin D deficiency was associated with disease progression types. In vivo vitro revealed anti-proliferative, anti-angiogenic, apoptosis,...

Objective.To adapt and validate the Indonesian version of FRAIL scale (Ina-FRAIL) SARC-F (Ina-SARC-F).Methods.The Ina-FRAIL Ina-SARC-F were developed through forwards-backwards translation, their validity (itemtotal item correlations), internal consistency (Cronbach's alpha), test-retest reliability (kappa statistic) determined.The diagnostic performance was evaluated using receiver operating characteristic curve analysis. Results. A total 101 (57 men 44 women) 64 (23 41 patients included in...

Pendahuluan Tenaga kesehatan berperan dalam meningkatkan derajat masyarakat dan berhak mendapatkan jaminan keselamatan kerja. Penelitian sebelumnya melaporkan kecelakaan kerja yang sering terjadi di rumah sakit adalah tertusuk jarum, teriris pisau, terluka terpercik cairan tubuh. Kejadian tersebut banyak belum terlaporkan karena padatnya jadwal pelayanan rendahnya persepsi terhadap risiko terpapar infeksi. Rendahnya tingginya kejadian menjadi tujuan penelitian ini dilakukan untuk mengetahui...

BACKGROUND: Nutmeg (Myristica fragrans H.), one of native plants Maluku Indonesia, has long been used as traditional medicines especially to treat tumors, externally skin infections. M. also important biological activities anticancer. However, antimelanoma activity remains unknown. The aim this study is compare extracts anticancer on melanoma B16-F10 cells by inducing apoptosis.METHODS: seed was extracted with ethanol then fractionated n-hexane, ethyl acetate, and n-butanol. were cultured...

Endurance exercise induces specific skeletal muscle adaptation by increasing mitochondrial oxidative phosphorylation eficiency and biogenesis. Many previous studies suggesting both PGC-1a COX IV as a potential biomarker of induced exercise. But most them only studied the effect long-term endurance exercise, whereas short-term remains unclear. To investigate physiological on expression mRNA in rat muscle. Twenty healthy male Wistar rats (Rattus norvegicus) aged 10-11 weeks old were used this...

Physical fitness is the ability of an athlete to fulfill physical activities that are needed for sport without becoming weary. This a very important thing determines athlete’s performance. The predominant component rhythmic gymnastics muscular endurance, muscle strength, power, and flexibility. study aimed gather information regarding profile Bandung City gymnastic athletes before competing in Pekan Olah Raga Daerah Jawa Barat (PORDA Jabar) XI event 2010. descriptive studywas conducted using...

Frailty syndrome is a state of decreased body function, thereby increasing susceptibility to poor clinical outcomes. The risks developing frailty increase in the elderly at Nursing Home. This study expected provide characteristic data as basis for prevention and management elderly. conducted by using descriptive quantitative design. taken FI-40 questionnaire consisting 40 questions Bandung done total sampling. There are 42(58.3%) pre-frail 7(9.7%) frail out 72 data. Pre-frail prevails mostly...

Background : Sarcopenia can lead to difficulty in physical activities, therefore, elderly cannot live independently. However, data on sarcopenia are not yet available Dr. Hasan Sadikin General Hospital. This study was conducted identify the frequency of occurrence and characteristics patients with sarcopenia. Methods used descriptive method from May October 2014. Total sampling performed medical records at Geriatric Outpatient Clinic Hospital during period 2012–2014. Variables observed were...

Public mobility is considered one of the factors thought to impact transmission SARS-CoV2. The Indonesian government has imposed six restriction policies since beginning COVID-19 pandemic cope this situation, however there been no comprehensive evaluation program. This study aimed examine correlation between and incidence during implementation policy in Indonesia. Secondary data on public mobility, acquired through Google Community Mobility Reports, new cases, recorded COVID Task Force...

Background: Metabolic syndrome (MetS) is a risk factor for cardiovascular disease and linked to obesity.Subjects with MetS who have normo-weight potentially show higher mortality morbidity.Purpose: This study aims reveal the critical essential metabolic parameters associated endothelial dysfunction in subjects compared obese.Patients Methods: The was designed using case-control approach.Ninety-nine (34 Normo-weight 65 obese) from urban population were enrolled this study.The components of...

Background: Hepatotoxicity induced by the combination of isoniazid (INH) and rifampicin (RIF) in treatment tuberculosis (TB) remains a major concern. Oxidative stress has role mechanism hepatotoxicity. Curcuma longa L. been widely used as traditional medicine shown antioxidant activity. This study aimed to provide evidence L protection against oxidative therapy.Methods: was an experimental on male Wistar rats weighing 150-200 grams, aged 8-10 weeks which were divided into negative control...

Tujuan: Praktik klinik yang dilaksanakan oleh mahasiswa sudah tentu menjadi sumber stres tersendiri bagi mahasiswa. Ketakutan lingkungan praktik akan dihadapi, perasaan kurang mampu dan tidak menjalin hubungan baik dengan staf dialami Untuk mengatasi kondisi tersebut dibutuhkan cara tepat untuk mengatasinya. Koping bisa dirasakan. mendapatkan koping tepat, tentunya strategi bertahan keluar dari tersebut.Penelitian ini bertujuan mengetahui gambaran tingkat stress, saat keperawatan dasar...

Fecal incontinence (FI) is the inability to control bowel movements, resulting in fecal leakage. If left untreated, FI can seriously impact long-term well-being of individuals affected. Recently, using secretome has become a promising new treatment method. The combines growth factors released outside cells during stem cell development, such as mesenchymal cells. It consists soluble proteins, nucleic acids, fats, and extracellular vesicles, which contribute different processes. primary aim...

ABSTRAK Sarkopenia adalah penurunan massa dan fungsi otot rangka yang disebabkan oleh penuaan. dapat meningkatkan morbiditas mortalitas pada lansia. Penyebab patofisiologi sarkopenia bersifat kompleks belum diketahui secara pasti hingga saat ini. Autophagy mempunyai peran penting untuk proses eliminasi daur ulang protein organel rusak sehingga sementara penuaan akumulasi berlebihan sebagai konsekuensi metabolisme merupakan salah satu penyebab terjadinya penyakit karena Kondisi autophagy...

Background : The six-minute walk test (6MWT) is a safe, easy to perform, and inexpensive evaluate the functional exercise capacity in elderly. purpose of this study was describe 6MWT distance achieved among elderly patients. Methods This descriptive conducted from January November 2014 using medical records geriatric outpatient clinic Department Internal Medicine at Dr. Hasan Sadikin General Hospital 2012 2014. main variable by 6MWT, compared based on age, sex, body mass index. Results...

BACKGROUND: Muscle loss is one of the features associated with aging significant impacts on quality life. Yap/Taz, effectors Hippo pathway, was shown to regulate organ size and may be aging. We postulate that Yap/Taz modulation play a role in maintaining muscle fiber or mediating function autophagy during sarcopenia. OBJECTIVE: The research aim explore sarcopenia its relationship expression. Additionally, we also explored skeletal tissue METHODS: conducted experiments two groups rats kept at...

Colorectal cancer is one of the most diagnosed cancers in world. KRAS mutations colon are being responsible for progressiveness and resistance standard therapeutic available. Marine sponge sources chemotherapy. Stylissa carteri a marine that lives Indonesia its anti-cancer effects starting to be explored nowadays. The purpose this study was determine cytotoxicity anti-proliferative effect ethanol extract against cells with HCT-116 cells. This an vitro using cell line which tested by...

Sedentary lifestyle can cause the accumulation of energy reserves in form lipids white adipose cells. Lifestyle modification by means exercise is done to reduce fat tissue (WAT). This study aims determine effect various intensities on histological changes Research method exploratory with Federer formula number samples carried out. Using 28 Wistar rats located at Central Laboratory Padjadjran University, Sumedang from May June 2022. The data taken were average diameter ± standard error (SEM)...

Abstract Background Browning of white adipose tissue (WAT) is a promising approach to obesity treatment. During browning, WAT transforms into beige through stimulation the peroxisome proliferator activated receptor γ (PPARγ). Nutmeg, one Indonesian herbs, reportedly has dual roles as PPARα/γ partial agonist. Even though nutmeg been traditionally used in body weight reduction, there limited information regarding potential role browning WAT. Objectives In this study, we explored effect seed...