Short stature remains a global problem and is associated with vitamin D status. Vitamin also neurosteroid regard to neurotrophic factors but its role in development unclear. Therefore, this study analyzed the relationships between D, NGF, GDNF, BDNF developmental status children history of short (<2 years). This research prospective cross-sectional conducted March 2022. The levels were measured stored biological materials from aged 2-4 years, their Ages Stages Questionnaire (ASQ-3) scores...

Patients with transfusion-dependent thalassemia experience iron dysregulation, which affects the immune response. Surface proteins such as FcγRIII (CD16), lipopolysaccharide receptor (CD14), and human leukocyte antigen (HLA-DR) on monocytes are crucial for innate adaptive responses. Blood monocytes, identified by their CD14 CD16 expression, show functional diversity during injury or inflammation. Considering mechanisms of vitamin D activation its potential interaction further investigation...

Background and Objectives: The prevalence of stunted children under 5 years in Indonesia is relatively high. Stunting a significant risk factor for wheezing disorders. asthma predictive index (API) identifies with recurrent disorder at developing during the first 3 years. However, its associated factors among has not been studied. This study aims to determine via API score factors. Materials Methods: cross-sectional was conducted Bandung District Health Center from October 2021 January 2022....

Background and Objectives: Acute Otitis Media (AOM) is a leading cause of morbidity in children, characterized by fever, otalgia, hearing loss. If untreated, AOM may progress to chronic complications requiring surgical management. Globally, factors such as allergies, environmental tobacco smoke, nutritional deficiencies are well-established risk factors, but Indonesia, particularly rural areas like Bandung Regency, limited awareness data exacerbate the burden disease. Smoking prevalence low...

BACKGROUND Cervical cancer is the fourth most common among women. The case fatality rate of advanced-stage cervical was approximately 50% in 2020 worldwide. A new approach to finding a better treatment outcome for needed. Research findings showed that cholecalciferol may benefit cell control. This study aimed understand impact supplementation on by radiotherapy. MATERIAL AND METHODS randomized controlled trial with pretest-posttest control group design conducted between 2021 and 2023 at Dr....

Background: Lymphopenia is associated with disease activity in adult patients systemic lupus erythematosus (SLE), but no similar studies exist among children. Furthermore, lymphopenia has only been used as a parameter of the SLE index (SLEDAI), not an independent marker. Objectives: This study aimed to ascertain marker related children SLE. Methods: was retrospective cohort on newly diagnosed The data were collected from January 2009 March 2017, including clinical manifestations, complete...

Henoch-Schönlein purpura (HSP) is the most common vasculitis in children, characterized by triad of symptoms; palpable without thrombocytopenia, abdominal pain, and arthritis. Renal involvement often occur children with HSP. No data on renal HSP Indonesia, especially West Java.To evaluate HSP.Retrospective study was conducted Department Child Health, Hasan Sadikin Hospital, from 2006 to 2011. Characteristics clinical manifestations reviewed medical record. diagnosed American College...

Vitamin D deficiency during pregnancy carries potential threat to fetal well being. Natural conversion of vitamin in the skin can be facilitated by direct ultra violet B (UVB) radiation, but effect is reduced wearing umbrellas, clothes, or sunblock cream. Muslim women wear hijab that allows only face and hands seen. With increasing proportion muslim lack fortification fish consumption Indonesia, it poses a problem for among pregnant women. This study aimed at finding best timing UVB exposure...

Background: Cow’s milk allergy is relatively common among Indonesian infantswho are not exclusively breastfed. Despite extensive hydrolyzed formula and aminoacid-based the recommended nutrition for infants with moderate-tosevere illness, all parents could provide those specialized formulas, presumablydue to high cost, low availability poor palatability. In that case, soy-basedinfant be an alternative nutrition. However, it was unknown whetherIndonesian mothers were aware on Objective: We...

Aim Vitamin D deficiency in early pregnancy may cause the disruption of fetal brain development and neurodevelopmental function. This study aimed to explore extent neurodevelopment could be associated with maternal vitamin deficiency. Methods A cohort was conducted Sukabumi Waled, West Java, Indonesia, beginning July 2016. Maternal serum 25(OH)‐vitamin measured between 10 14 weeks gestational age. Child using Ages Stages Questionnaire‐3 (ASQ‐3) at age 3, 6 12 months. Results total 141...

The role of vitamin D in placental functions and fetal growth had been addressed many reports with conflicting results. However, such report is limited for Indonesian population. aim this study was to explore the association between maternal level first trimester biometry later stage pregnancy adjusted OR other determinants like hemoglobin ferritin level.From July 2016 a prospective cohort pregnant women begun four cities West Java, Indonesia. Data on D, ferritin, level, demography were...

Children with stunted growth have an increased risk of wheezing, and studies shown that low levels vitamin D interleukin (IL)-10, along IL-4 CD23+ expression, are present in asthmatic children. To date, it is not known whether these factors related to the incidence asthma This case-control study investigated association between D, IL-4, IL-10 expression bronchial The included 99 children aged 24-59 months, i.e., 37 stunted-sthmatic (cases), 38 without asthma, 24 non-stunted asthma. All were...

The prevalence of neglected tropical diseases, specifically those caused by soil-transmitted helminths (STHs) and other parasites that infest the intestine as part their life cycle, remains a problem in Indonesia. We assessed effects deworming programs socioeconomic ecological factors on incidence rate infections with STHs an urban area Bandung Regency. recruited 361 children stunted growth who met inclusion criteria, 48 were at high risk STH infection. study was conducted between September...

Abstract Background Atrial septal defects (ASD) are the most common type of adult congenital heart disease (ACHD) associated with a high risk developing pulmonary arterial hypertension (PAH). ASD closure is not recommended in patients PAH and Pulmonary Vascular Resistance (PVR) ≥ 5 Wood Unit (WU). Noninvasive methods have been proposed to measure PVR; however, their accuracy remains low. Right Ventricle (RV) - Artery (PA) coupling defined as ability RV adapt high-resistance conditions....

Studies had shown that iron-cycling was disturbed by inflammatory process through the role of hepcidin. Pregnancy is characterized shifts interleukin. Our objective to determine if 25(OH) vitamin D (colecalciferol) status associated with ferritin, anemia, and its changes during pregnancy. Method. A cohort study done in 4 cities West Java, Indonesia, beginning July 2016. Subjects were followed up until third trimester. Examinations included maternal colecalciferol, haemoglobin level. Result....

BACKGROUND Melanoma is one of the most aggressive types cancer and it has shown a remarkable surge in incidence during last 50 years. been projected to be continuously rising future. Therapy for advanced-type melanoma still challenge due low response rate poor 10-year survival. Interestingly, several epidemiological preclinical studies had reported that vitamin D deficiency was associated with disease progression types. In vivo vitro revealed anti-proliferative, anti-angiogenic, apoptosis,...

Objective: The Indonesia Basic Health Research 2018 indicates that Indonesian children are still among the shortest in world.When referred to World Organization Child Growth Standards (WHOCGS), prevalence of stunting reaches up 43% several districts.Indonesian National Reference Charts (INGRC) were established order better distinguish between healthy short and with growth disorders.We analyzed height weight measurements using INGRC WHOCGS.Methods: 6972 boys 5800 girls (n=12,772), aged 0-59...

Heart disease is the major cause of death in thalassemia patients. Repeated blood transfusions and hemolysis iron overload also disrupts hydroxylation synthesis vitamin D, causing D deficiency. Vitamin deficiency associated with cardiac dysfunction.The purpose this study was to determine association between levels left ventricular function N-terminal pro-brain natriuretic peptide (NT-proBNP) children overload.A cross-sectional conducted March-April 2015 clinic, Department Child Health, Dr....

Background Interferon gamma release assays (IGRAs) are widely used to determine latent tuberculosis infection status. However, its pregnancy-affected performance and cost-expensive nature warrants for different alternatives pregnant women. This study aims evaluate the diagnostic of several alternative cytokines, including interleukin 2 (IL-2), 10 (IL-10), interferon gamma-induced protein (IP-10) identify status in Materials methods 123 womens were recruited this study. The IGRA was...