A5060000001- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Boron Compounds in Chemistry
- Photodynamic Therapy Research Studies
- Medical Imaging and Pathology Studies
- Drug Transport and Resistance Mechanisms
- Bone Tissue Engineering Materials
- Chemical Synthesis and Characterization
- Nuclear reactor physics and engineering
- Cancer therapeutics and mechanisms
- Advanced Nanomaterials in Catalysis
- Radiomics and Machine Learning in Medical Imaging
- Antibiotic Resistance in Bacteria
- Synthesis and biological activity
- Pediatric Urology and Nephrology Studies
- Cancer and biochemical research
- Click Chemistry and Applications
- Antimicrobial Peptides and Activities
- Pharmacological Receptor Mechanisms and Effects
- ATP Synthase and ATPases Research
- Fluoride Effects and Removal
- Machine Learning in Bioinformatics
- Tannin, Tannase and Anticancer Activities
National Research and Innovation Agency
2023-2024
National Nuclear Energy Agency of Indonesia
2016-2024
Bandung Institute of Technology
2024
Propulsion Science and Technology (United States)
2016-2020
Infectious diseases are still the leading cause of death in world. The accurate technique for early detection and determination exact location infection body is needed. Nuclear techniques capable this purpose while other such as MRI, USG CT-SCAN sometimes cannot be applied. 99m Tc-kanamycin radiopharmaceutical complex kanamycin technetium-99m radionuclide, was used bacterial infection. labeling studies has been carried out by indirect method using pyrophosphate a co-ligand with results...
Brain imaging is a technique that scientists and physicians use to view monitor brain areas diagnose abnormalities in the brain. This study aimed develop potential labeled compound for non-invasive imaging. Pramipexole (a drug thµat has ability penetrate blood-brain barrier) been successfully iodine-131 (131I) through diazonium salt reaction, followed by sandmeyer reaction at room temperature, physicochemical characterization carried out. The parameters studied were computation simulation,...
High-Z ion doped hydroxyapatite, including zirconium hydroxyapatite has prospects as drug candidates for x-ray induced dynamic therapy (XDT) in cancer therapy. Its nanosized combined with could assist accumulates cell compared to non hydroxyapatite. However the mechanism of internalization is currentle unknown. In this study, scandium-46 (46Sc) labeled (HApZr) and 46Sc (HAp) A549 lung line was carried out understand effect doping into HAp. Docking study HApZr HAp binding energy several...
The therapy uses beta-ray (β-) base radiopharmaceutical was the main option in developing countries but has obsolete advanced like United States of America and many Europe countries. alpha (α) a substitute radioisotope that used for various therapies. To follow novelty trend, Indonesian research will build cyclotron Jogjakarta with code name DECY-13 to produce new radioisotopes. preliminary study should be carried out prepare when finished commissioned it producing radioisotopes optimally....
Neurodegenerative diseases are a global priority disease. According to the World Health Organization (WHO), it is estimated that by 2050, there will be 152 million people with neurodegenerative diseases. Currently, method used for brain imaging PET/CT, most widely radiopharmaceutical being 18F-FDG [7,8]. determine glucose metabolism, however does not have specific receptor. Pramipexole compounds can cross blood-brain barrier and high specificity dopamine receptors. By modifying labelling...
99mTc-GSH merupakan radiofarmaka untuk mendeteksi kanker leher dan kepala. Kanker kepala terbentuk pada jaringan atau organ yang terdapat di area seperti hipofaring, telinga, kelenjar saliva, mata, laring, tiroid. Glutataion(GSH) memiliki molekul kecil sehingga dapat berpenetrasi dengan baik didalam saluran kapiler mengalami inflamasi, payudara serta tumor. Tujuan dari penelitian ini adalah mengetahui estimasi dosis manusia berbasis uji biodistribusi hewan model mencit. Uji kemurnian...
STUDI AWAL ESTIMASI DOSIS INTERNAL 99mTc-MDP HASIL PRODUKSI PSTNT-BATAN PADA MANUSIA UNTUK DETEKSI METASTASIS DAN INFLAMASI TULANG BERBASIS UJI BIODISTRIBUSI HEWAN MODEL MENCIT. Kanker adalah sel abnormal yang dapat menyebar sampai ke tulang. Pemeriksaan dilakukan dengan bone-scan menggunakan radiofarmaka. Bandung melakukan penelitian radiofarmaka penyidik tulang yaitu MDP ditandai radionuklida teknesium-99m. Penelitian ini bertujuan memperoleh estimasi dosis internal sebagai metastasis dan...
Translocator protein 18-kDa, broadly known as TSPO, is a mitochondrial membrane protein, previously identified the peripheral benzodiazepine receptor (PBR). TSPO involves in broad number of biochemical events, such steroidogenesis, cholesterol transport, cell survival and death, proliferation, carcinogenesis. Several investigations have reported roles various types cancers, including colorectal cancer, brain melanoma, breast prostate lung cancer. It was found that upregulated cancer cells,...
The use of low activity concentration 99m Tc would result in low-quality labeled compound for diagnostic purpose. will alter biodistribution and lead to false imaging applications. Electrodeposition could be an alternative method increasing the solution. influence electrodeposition parameters such as electrolytes, electrolyte, voltage time deposition were examined find optimum condition electrodeposition. Electrolytes evaluated NaNO 2 , Na-oxalate, NaOH, NaCl. Concentration factor is defined...
PREPARASI SENYAWA ANTI KANKER APIGENIN BERTANDA RADIOIODIUM-131 UNTUK STUDI BIOAKTIVITAS. Apigenin merupakan senyawa flavonoid yang mempunyai potensi sebagai anti kanker, oksidan, dan inflamasi dengan toksisitas intrinsik rendah. Untuk mengetahui bioaktivitas apigenin, dapat dilakukan radioiodinasi kemudian dilanjutkan studi praklinis menggunakan hewan uji. Pada penelitian ini preparasi apigenin bertanda radioiodium-131 metode kloramin-T optimasi berbagai parameter serta kondisi penandaan....
Cancer is a genetic disease that causes by mutations in DNA from normal cell to cancer cell. As result, the grows quickly and spread other parts of body; this condition became leading cause death. One detection methods currently used detect tumors metastatic tissues conducted with radiopharmaceutical [18F] fluoro-2-deoxy-2-D-glucose (18F-FDG). This method quite accurate but relatively expensive because it needs PET / CT camera still limited Indonesia. With these limitations, previous studies...
Angka kematian akibat infeksi dari tahun ke terus meningkat. Berbagai usaha dilakukan guna menekan angka yang ada, salah satu contohnya dengan pengembangan metode diagnostik berbasis nuklir. 99mTc-Kanamycin merupakan kit potensial untuk dikembangkan menjadi senyawa bertanda dapat digunakan dalam mendiagnosis penyakit infeksi. Kanamycin adalah sebuah antibiotik berspektrum kerja luas telah lama pertumbuhan bakteri baik itu Gram positif maupun negatif. Selain harus memenuhi standar sifat...
We synthesised and biologically evaluated two new hybrid probes [131I]BPF-01 [131I]BPF-02 which were built from three structural entities: benzothiazole-phenyl, fluorescein isothiocyanate (FITC), iodine-131. These designed for potential applications in assisting surgical procedures of solid cancers. The cytotoxicity study demonstrated that fluorescent BPF-01 (31.23 μg/mL) BPF-02 (250 relatively not toxic to normal immortalized human keratinocytes (HaCaT) cells, as indicated by the percentage...
Photodynamic therapy has been recognized as a viable approach for lung cancer treatment. The use of photosensitizer agents to improve treatment efficacy raised interest further study. nanoparticles drug delivery and offers various advantages because their rapid cellular accumulation distribution into target organs. Based on properties, several trigger adverse effects during cytotoxicity new HApZr candidates photodynamic demonstrated in A549 cells. This nanoparticle also increased the...
The labeled compound 131I-Hippuran has been known for a long time and was still being used by some hospitals as medical kit the study of dynamics kidney function. application Labelled begins intravenous injection to patients, then monitor process biodistribution, secretion, excretion using Renographs. Bandung TRIGA 2000 reactor obtained an operating license from BAPETEN in 2017, at 800 kW irradiate various elements including Tellurium produce radioisotope Iodine-131. Iodine-131 material...