A5083871163- Public Health and Nutrition
- Cervical Cancer and HPV Research
- Radiopharmaceutical Chemistry and Applications
- Ovarian cancer diagnosis and treatment
- Legal and Policy Analysis in Indonesia
- Healthcare Quality and Satisfaction
- Endometrial and Cervical Cancer Treatments
- Nanoplatforms for cancer theranostics
- Mental Health and Well-being
- Preterm Birth and Chorioamnionitis
- Bone Tissue Engineering Materials
- Medical Imaging and Pathology Studies
- COVID-19 Prevention and Impact
- Epigenetics and DNA Methylation
- Pregnancy-related medical research
- Cancer-related Molecular Pathways
- PARP inhibition in cancer therapy
- Estrogen and related hormone effects
- Ectopic Pregnancy Diagnosis and Management
- Inflammatory Biomarkers in Disease Prognosis
- Health and Education Studies
- Autoimmune Neurological Disorders and Treatments
- Boron Compounds in Chemistry
- CNS Lymphoma Diagnosis and Treatment
- Bone health and treatments
National Research and Innovation Agency
2021-2025
National Nuclear Energy Agency of Indonesia
2016-2024
Udayana University
2015-2024
Rumah Sakit Umum Pusat Sanglah Denpasar
2015-2024
Theranostics (New Zealand)
2023
Gunma University
2020-2021
Diponegoro University
2021
Nuclear Energy Agency
2018
Propulsion Science and Technology (United States)
2017
This study aimed to synthesize cetuximab (CTX) conjugated hydroxyapatite zirconium (HApZr-CTX) as a nanocarrier for active delivery of photosensitizer and therapeutic radionuclide. The system enabled targeted radioenhancer in X-ray dynamic therapy radioimmunotherapy lung cancer. results showed that HApZr-CTX had the main characteristics crystal powder diffraction (XRD), with particle size twice bigger, according DLS-PSA TEM measurements. Cellular ROS generation was elevated almost three...
Persalinan preterm merupakan persalinan yang terjadi pada usia kehamilan antara 20 minggu sampai 37 minggu. dapat kapan dan dimana saja karena kelahiran masalah global. Etiologi patofisiologi bersifat multifaktorial, hal ini menyebabkan sulitnya mengetahui penyebab pasti dari tersebut. Sebagai tenaga medis diperlukannya pemahaman mengenai karakteristik agar mampu memberikan pencegahan penanganan sehingga menurunkan angka kematian ibu bayi. Penelitian penelitian deskriptif retrospektif dengan...
The coronavirus disease 2019 (COVID-19) has become a substantial threat to the international health sector and global economy. As of 26 December 2021, number mortalities resulting from COVID-19 exceeded 5.3 million worldwide. absence an effective non-vaccine treatment prompted quest for prophylactic agents that can be used combat COVID-19. This study presents feasibility chicken egg yolk antibody (IgY) anti-receptor-binding domain (RBD) spike SARS-CoV-2 as strong candidate neutralize virus...
Alzheimer's disease (AD) often leads to dementia, causing cognitive decline and increased care needs. Rivastigmine (RV) is a key AD treatment, but its brain delivery limited by the blood-brain barrier (BBB). Aside from oral, olfactory, intradermal injection (i.d.) routes, application of polymeric microneedles via trigeminal nerve on facial skin as pretreatment, followed solid lipid nanoparticle RV-loaded thermosensitive gel (PMN-SLN-RV-TG), an alternative deal with problems. This study aims...
Agricultural waste, particularly lignocellulose, has been used in the second generation of biogas. Coffee pulp and chicken feathers can be developed as biogas raw materials because their suitability a substrate. This study investigates effect percentage total solids (TS), carbon to nitrogen ratio (C/N, g/g), delignification pretreatment on production from coffee feathers, aims compose kinetics using modified Gompertz model. The results show that adjusting TS at low-level speeds up...
: Objective: Periodontal dressing is a protective material that used on post-surgical periodontal to protect the surface of wound and provides comfort sense patient. This study was conducted determine effect dressings containing silver nanoparticles by evaluating inflammatory parameters using 99mTc-ciprofloxacin; radiopharmaceutical can be for diagnosing infection inflammation. Methods: research carried out purely experimental 24 male Sprague Dawley rats divided into 4 groups. First group...
Abstract Chemotherapy-induced cognitive impairment (CICI) is an of memory, learning power, concentration, reasoning, executive function, attention, and visuospatial during after chemotherapy exposures. No proven safe effective therapeutic regimen are available to improve function in CICI patients. To evaluate the safety effectiveness curcumin extract This study was a double-blind randomized controlled trial clinical patients with cervical carcinoma who underwent carboplatin-paclitaxel from...
Summary Polycystic ovary syndrome (PCOS) is a condition that affects fertility. There are two types of PCOS; the normal/lean type and overweight/obese type. The aim this study was to assess baseline characteristics, ovarian response, quality oocytes, embryos, pregnancy, implantation live birth rates in patients with PCOS undergoing ICSI compared without PCOS. This retrospective case–control analytical included 38 17 PCOS, 98 Parameters were observed based on response dosage duration...
To characterize HPV16 E6/E7 mutation and its association with p53 expression among Indonesian women cervical cancer.This is a cross-sectional study involving 31 pathologically proven cancer infection. Data about the clinical characteristics of population were obtained from medical records. Biopsy specimen mass each participant was for DNA isolation. The ORFs E6 E7 genes amplified using specific primer designed according to K02718/HPV16R gene sequence GenBank. Sequencing performed software...
There are challenges related to cancer treatment, namely, targeting and biocompatibility associated with a drug vehicle. This research aims prepare theranostic vehicle based on porous silica nanoparticles (PSN) controllable nanoparticle size, supporting properties, biocompatible. The synthesis method combined the Stöber process liquid crystal templating using dispersant pore expander. Triethanolamine (TEA) Pluronic F-127 were as steric stabilizer dispersing agent, while n-hexane was used...
Objective: To understand the basic mechanism and dynamic regulation that underlies epithelial-to-mesenchymal transition (EMT) in ovarian cancer (OC) cells. Mechanism: A literature review using evidences from several data bases (i.e., PubMed, EMBASE, Web of Science, Medline, Cochrane, Science Direct, Google Scholar) were conducted to describe EMT OC Finding Brief: is a complex epigenetic reprogramming orchestrated by specific transcription factors (TFs) multiple upstream activators...
Background: Cervical cancer is the most common gynecologic in women. It main cause of cancer-related death women developing countries. Indonesia second affecting Indonesian and prevalence relatively stable last 30 years. was closely related to histologic type itself. A squamous cell carcinoma has a specific route local spreading lymphatic route. The sample this study are cervical patients who underwent radical hysterectomy from January 1 December 31, 2015 Sanglah Hospital Denpasar, Bali. aim...
BACKGROUND: The need for clinically useful biomarkers which can predict the surgical outcome after primary debulking surgery (PDS) in patients with advance ovarian cancer (AOC) is really important. Insulin-like growth factor-binding protein 2 (IGFBP2) main binding expressed by cells, plays a prominent role promoting proliferation, driving invasion, and suppressing apoptosis. This study was conducted to assess performance of IGFBP2 predicting PDS AOC.METHODS: Twenty-four subjects AOC (Stage...
BACKGROUND: Malignant Ovarian Germ Cell Tumors (MOGCT) most commonly occur in young women the reproductive age group. Timely antenatal diagnosis and treatment of tumour to enhance maternal perinatal outcomes are main challenges confronting obstetrician gyne-oncologist.
 CASE PRESENTATION: Here we present three cases pregnancy complicated with MOGCTs. The first case (immature teratoma) was by psychological symptoms consistent stress histopathological examination confirmed premature...
Aim: This study aims to determine the relationship between beta-hCG level in vaginal washing fluid with incidence of premature rupture membranes (PROM) and cut-off value predicting occurrence PROM Materials Methods: diagnostic was carried out delivery room Emergency Ward, Sanglah Hospital, Denpasar from May 2020 July 2020. The wash taken after then examined at Clinical Pathology Laboratory, Udayana University/Sanglah General Hospital Bali. Results: Thirty-five subjects that had met inclusion...
Brain imaging is a technique that scientists and physicians use to view monitor brain areas diagnose abnormalities in the brain. This study aimed develop potential labeled compound for non-invasive imaging. Pramipexole (a drug thµat has ability penetrate blood-brain barrier) been successfully iodine-131 (131I) through diazonium salt reaction, followed by sandmeyer reaction at room temperature, physicochemical characterization carried out. The parameters studied were computation simulation,...
High-Z ion doped hydroxyapatite, including zirconium hydroxyapatite has prospects as drug candidates for x-ray induced dynamic therapy (XDT) in cancer therapy. Its nanosized combined with could assist accumulates cell compared to non hydroxyapatite. However the mechanism of internalization is currentle unknown. In this study, scandium-46 (46Sc) labeled (HApZr) and 46Sc (HAp) A549 lung line was carried out understand effect doping into HAp. Docking study HApZr HAp binding energy several...
The therapy uses beta-ray (β-) base radiopharmaceutical was the main option in developing countries but has obsolete advanced like United States of America and many Europe countries. alpha (α) a substitute radioisotope that used for various therapies. To follow novelty trend, Indonesian research will build cyclotron Jogjakarta with code name DECY-13 to produce new radioisotopes. preliminary study should be carried out prepare when finished commissioned it producing radioisotopes optimally....
The preclinical study is an important stage in drug discovery and development. One of the keys to developing therapeutic methods selecting animal model that suitable capable answering research questions. Animal models are required develop cancer diagnostics therapies, particularly for prostate cancer. Due their ability as diagnostic tools, radiopharmaceuticals one alternative therapies currently gaining significant interest. In this study, we generated a syngenic mice using C57BL/6 which...