A5027951848- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Global Maternal and Child Health
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Reforms
- Child Nutrition and Water Access
- Cervical Cancer and HPV Research
- Immune responses and vaccinations
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Emergency and Acute Care Studies
- Global Public Health Policies and Epidemiology
- Healthcare Policy and Management
- Global Health Care Issues
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- HIV/AIDS Impact and Responses
United Nations Children's Fund
2017-2025
London School of Hygiene & Tropical Medicine
2012-2023
University of London
2006-2023
United Nations Children's Fund Kosovo
2021-2023
United Nations Children's Fund Niger
2021-2023
University of Botswana
2023
United Nations Children's Fund India
2021-2023
United Nations Children's Fund Cameroon
2021-2023
Ministry of Health
2023
Faculty of Public Health
2011-2021
Significance To aid in prioritizing the development of tuberculosis (TB) vaccines most likely to reach 2050 TB elimination goal, we estimated impact and cost-effectiveness a range vaccine profiles low- middle-income countries. Using mathematical modeling, show that targeted at adolescents/adults could have much greater on burden over 2024–2050 time horizon than those infants. Such also be cost-effective, even with relatively high prices. Our results suggest achieve goals, future should focus...
The WHO health systems Building Blocks framework has become ubiquitous in research. However, it was not developed as a research instrument, but rather to facilitate investments of resources systems. In this paper, we reflect on the advantages and limitations using applied research, experienced three empirical vaccine studies have undertaken.We argue that while is valuable because its simplicity ability provide common language for researchers, suitable analysing dynamic, complex inter-linked...
To synthesise lessons learnt and determinants of success from human papillomavirus (HPV) vaccine demonstration projects national programmes in low- middle-income countries (LAMICs).Interviews were conducted with 56 key informants. A systematic literature review identified 2936 abstracts five databases; after screening 61 full texts included. Unpublished literature, including evaluation reports, was solicited country representatives; 188 documents received. data extraction tool interview...
Background: Childhood immunisation services have been disrupted by the COVID-19 pandemic. WHO recommends considering outbreak risk using epidemiological criteria when deciding whether to conduct preventive vaccination campaigns during Methods: We used two three models per infection estimate health impact of 50% reduced routine coverage in 2020 and delay campaign from 2021 for measles Bangladesh, Chad, Ethiopia, Kenya, Nigeria, South Sudan, meningococcal A Burkina Faso, Niger, yellow fever...
Knowledge of treatment cost is essential in assessing effectiveness healthcare. Evidence the potential impact implementing available interventions against childhood illnesses developing countries challenges us to define costs treating these diseases. The purpose this study describe total associated with pneumonia, malaria and meningitis children less than five years seven Kenyan hospitals.Patient resource use data were obtained from largely prospective evaluation medical records household...
The diagnosis and treatment of malaria is often based on syndromic presentation (presumptive treatment) microscopic examination blood films. Treatment approach has been found to be costly, contributes the development drug resistance, while time-consuming labour-intensive. Also, there lack trained microscopists reliable equipment especially in rural areas Nigeria. However, although rapid diagnostic tests (RDTs) have improved ease appropriate diagnosis, cost-effectiveness RDTs case management...
Introduction In recent years, an unprecedented emphasis has been given to the control of neglected tropical diseases, including soil-transmitted helminths (STHs). The mainstay STH is school-based deworming (SBD), but mathematical modelling shown that in all very low transmission settings, SBD unlikely interrupt transmission, and new treatment strategies are required. This study seeks answer question: it possible STH, and, if so, what most cost-effective strategy delivery system achieve this...
In May, 1974, WHO launched the Expanded Programme on Immunization—the global programme to immunise children worldwide with a set of (at time) six core vaccines. 40 years on, GAVI Alliance has brought us together, group 29 leading technical experts in health and development economics, cognitive development, epidemiology, disease burden, economic modelling review understand broader outcomes vaccines beyond morbidity mortality, identify research opportunities, create agenda that will help...
As more new and improved vaccines become available, decisions on which to adopt into routine programmes frequent complex. This qualitative study aimed explore processes of national decision-making around vaccine adoption understand the factors affecting these decisions. Ninety-five key informant interviews were conducted in seven low- middle-income countries: Bangladesh, Cameroon, Ethiopia, Guatemala, Kenya, Mali South Africa. Framework analysis was used issues both within between countries....
Estimates of the burden disease in adults sub-Saharan Africa largely rely on models sparse data. We aimed to measure living a rural area coastal Kenya with use linked clinical and demographic surveillance data.We used data from 18,712 admitted Kilifi District Hospital (Kilifi, Kenya) between Jan 1, 2007, Dec 31, 2012, 790,635 person-years observation within Health Demographic Surveillance System, establish rates major causes admission hospital. These were also model disease-specific...
From 2012 to 2016, Gavi, the Vaccine Alliance, provided support for countries conduct small-scale demonstration projects introduction of human papillomavirus vaccine, with aim determining which vaccine delivery strategies might be effective and sustainable upon national scale-up. This study reports on operational costs cost determinants different vaccination within these across twelve using a standardized micro-costing tool. The World Health Organization Cervical Cancer Prevention Control...
Abstract There are marked differences in methods used for undertaking economic evaluations across low‐income, middle‐income, and high‐income countries. We outline the most apparent dissimilarities reflect on their underlying reasons. randomly sampled 50 studies from each of three country income groups a comprehensive database 2844 published between January 2012 May 2014. Data were extracted ten methodological areas: (i) availability guidelines; (ii) research questions; (iii) perspective;...
Objective To evaluate the effectiveness and cost of pan-London pharmacy initiative, a programme that allows administration seasonal influenza vaccination to eligible patients at pharmacies. Design We analysed 2013–2015 data on uptake in pharmacies via Sonar reporting system, total 2011–2015 ImmForm general practitioner (GP) system data. conducted an online survey London pharmacists who participate assess time use data, vaccine choice, investment costs opinions about programme. GPs choice...
People with diabetes have an increased risk of developing active tuberculosis (TB) and are more likely to poor TB-treatment outcomes, which may impact on control TB as the prevalence is increasing worldwide. Blood transcriptomes altered in patients relative healthy individuals. The effects intermediate hyperglycemia (IH) this transcriptomic signature were investigated enhance understanding immunological susceptibility diabetes-TB comorbidity.Whole blood samples collected from (glycated...
The development, distribution and delivery of COVID-19 vaccines following the outbreak global coronavirus pandemic in February 2020 is largest immunization action history. To assist with planning resource mobilization efforts, a global-level model was used to estimate expected vaccine costs employing data from literature on childhood adult flu delivery. However, country-level studies were needed validate these estimates, learn lessons for future pandemics, plan forthcoming vaccination...