A5102982820- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Inflammatory mediators and NSAID effects
- Fatty Acid Research and Health
- Irrigation Practices and Water Management
- Stroke Rehabilitation and Recovery
- Eicosanoids and Hypertension Pharmacology
- Virology and Viral Diseases
- Healthcare Systems and Reforms
- Parasitic infections in humans and animals
- Estrogen and related hormone effects
- Global Health Care Issues
- Muscle activation and electromyography studies
- Global Health and Epidemiology
- Immune responses and vaccinations
- Plant Water Relations and Carbon Dynamics
- Tuberculosis Research and Epidemiology
- Synthesis and biological activity
- Parasites and Host Interactions
- Neurological disorders and treatments
- Global Public Health Policies and Epidemiology
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Balance, Gait, and Falls Prevention
Bangladesh Council of Scientific and Industrial Research
2022-2023
Berkshire College of Agriculture
2023
International Centre for Diarrhoeal Disease Research
2011-2021
Columbia University
2013-2019
Columbia University Irving Medical Center
2017-2019
PAREXEL International (United Kingdom)
2017
University of Southern Queensland
2014
University of Southern California
2004-2013
Brigham and Women's Hospital
2013
Harvard University
2013
We recently uncovered two new families of potent docosahexaenoic acid-derived mediators, termed D series resolvins (Rv; resolution phase interaction products) and protectins. Here, we assign the stereochemistry conjugated double bonds chirality alcohols present in resolvin D1 (RvD1) its aspirin-triggered 17R epimer (AT-RvD1) with compounds prepared by total organic synthesis. In addition, acid was converted a single lipoxygenase “one-pot” reaction to RvD1 vitro. The synthetic matched...
The resolvins (Rv) are lipid mediators derived from omega-3 polyunsaturated fatty acids that act within a local inflammatory milieu to stop leukocyte recruitment and promote resolution. Resolvin E1 (RvE1; (5S,12R,18R)-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid) is an oxygenase product eicosapentaenoic acid displays potent anti-inflammation/pro-resolution actions in vivo. Here, we determined whether oxidoreductase enzymes catalyze the conversion of RvE1 assessed biological activity...
Thymidine kinase 2, encoded by the nuclear gene TK2, is required for mitochondrial DNA maintenance. Autosomal recessive TK2 mutations cause depletion and multiple deletions of mtDNA that manifest predominantly as a myopathy usually beginning in childhood progressing relentlessly. We investigated safety efficacy deoxynucleoside monophosphate therapies.We administered monophosphates to 16 TK2-deficient patients under compassionate use program.In 5 with early onset severe disease, survival...
ABSTRACT The heritability of sodium and potassium transport to the xylem was measured by regression F n+1 , on n means in two segregating breeding populations rice ( Oryza sativa L.). narrow‐sense heritabilities shoot concentration were 0.42 0.43 populations, respectively, corresponding values for 0.46 0.52. sodium: ratio apparently heritable (0.36 0.40) because it regressed positively negatively concentration. There no significant relationship between concentrations themselves. It is...
Abstract The proteasome inhibitor bortezomib (Velcade) is known to trigger endoplasmic reticulum (ER) stress via the accumulation of obsolete and damaged proteins. selective cyclooxygenase-2 (COX-2) celecoxib (Celebrex) causes ER through a different mechanism (i.e., by causing leakage calcium from into cytosol). Each these two mechanisms has been implicated in anticancer effects respective drug. We therefore investigated whether combination drugs would lead further increased enhance their...
Abstract A drawback of extensive coxib use for antitumor purposes is the risk life-threatening side effects that are thought to be a class effect and probably due resulting imbalance eicosanoid levels. 2,5-Dimethyl-celecoxib (DMC) close structural analogue selective cyclooxygenase-2 inhibitor celecoxib lacks cyclooxygenase-2–inhibitory function but nonetheless able potently mimic in vitro vivo. To further establish potential usefulness DMC as an anticancer agent, we compared various coxibs...
Abstract Background In endemic countries such as Bangladesh, consequences of cholera place an enormous financial and social burden on patients their families. Cholera vaccines not only provide health benefits to susceptible populations but also have effects the earning capabilities stability family. Community-based research evaluations are necessary understand perceptions about practices community relating oral vaccines. This may help identify ways in which be successfully introduced, other...
Abstract Background 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex ® ) that lacks COX-2-inhibitory function. However, despite its inability to block COX-2 activity, DMC able potently mimic anti-tumor effects in vitro and vivo, indicating both these drugs are involve targets other than exert their recognized cytotoxic effects. molecular components involved mediating drugs' apoptosis-stimulatory consequences...
As more new and improved vaccines become available, decisions on which to adopt into routine programmes frequent complex. This qualitative study aimed explore processes of national decision-making around vaccine adoption understand the factors affecting these decisions. Ninety-five key informant interviews were conducted in seven low- middle-income countries: Bangladesh, Cameroon, Ethiopia, Guatemala, Kenya, Mali South Africa. Framework analysis was used issues both within between countries....
The objective of this study was to assess the readiness health facilities for diabetes and cardiovascular services in Bangladesh.This a cross-sectional survey.This used data from nationwide Bangladesh Health Facility Survey conducted by Ministry Social Welfare 2014.A total 319 delivering focused on diseases (CVD) were included survey. Some these run public sector while others managed private non-governmental organisations. It mix primary secondary care facilities.The outcome services. We...
Background. After stroke, recovery of movement in proximal and distal upper extremity (UE) muscles appears to follow different time courses, suggesting differences their neural substrates. Objective. We sought determine if presence or absence motor evoked potentials (MEPs) differentially influences volitional contraction strength an arm muscle versus intrinsic hand muscle. also related MEP status interjoint coordination fractionation, as measured by the Fugl-Meyer Assessment (FMA). Methods....
Background: Functional upper extremity (UE) motion enables humans to execute activities of daily living (ADLs). There currently exists no universal language systematically characterize this type or its fundamental building blocks, called primitives. Without a standardized classification approach, pooling mechanistic knowledge and unpacking rehabilitation content will remain challenging. Methods: We created taxonomy functional UE motions occurring during ADLs, classifying them by presence,...
Tuberculosis is characterized by granuloma formation and caseous necrosis, but the factors causing tissue destruction are poorly understood. Matrix metalloproteinase (MMP)-9 (92-kDa gelatinase) secretion from monocytes stimulated Mycobacterium tuberculosis (M. tb) associated with local injury in patients. We demonstrate strong immunohistochemical MMP-9 staining monocytic cells at center of adjacent to necrosis M. tb-infected patient lymph nodes. Minimal inhibitor MMPs-1 indicated that...
CCL5 (or RANTES (regulated upon activation, normal T cell expressed and secreted)) recruits lymphocytes monocytes. The source regulation of in pulmonary tuberculosis are unclear. Infection the human alveolar epithelial line (A549) by Mycobacterium caused no secretion little monocyte secretion. Conditioned medium from tuberculosis-infected monocytes (CoMTB) stimulated significant A549 cells primary alveolar, but not upper airway, cells. Differential responsiveness small airway bronchial to...
AbstractThe non-steroidal anti-inflammatory drug (NSAID) celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that has shown some promising results as an anti-cancer drug. However, the question arose to whether or not its COX-2-inhibitory function required for anti-tumorigenic properties. We therefore employed dimethyl-celecoxib (DMC), which close structural analog of lacks function, investigate this question. By performing combination in vitro and vivo studies with Burkitt’s lymphoma...
Background. One of the key concerns in determining appropriateness establishing a measles eradication goal is its potential impact on routine immunization services and overall health system. The objective this study was to evaluate accelerated elimination activities (AMEAs) systems 6 countries: Bangladesh, Brazil, Cameroon, Ethiopia, Tajikistan, Vietnam.
The first total synthesis of stereochemically pure resolvin D3 and aspirin-triggered is reported. These enzymatic metabolites docosahexaenoic acid (DHA) have potent anti-inflammatory pro-resolving actions. convergent synthetic strategy based on enantiomerically starting materials, it highly stereocontrolled.
Mobile phone-based technology has been used in improving the delivery of healthcare services many countries. However, data on effects this primary resource-poor settings are limited. The aim study is to develop and test a mobile system improve health, population nutrition rural Bangladesh evaluate its impact service delivery.The will use quasi-experimental pre-post design, with intervention comparison areas. Outcome indicators include: antenatal care (ANC), care, postnatal (PNC), neonatal...