A5041918314- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Patient Satisfaction in Healthcare
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Healthcare Systems and Technology
- Botulinum Toxin and Related Neurological Disorders
- Reproductive tract infections research
- Vibrio bacteria research studies
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Streptococcal Infections and Treatments
- Healthcare Policy and Management
- Clinical Nutrition and Gastroenterology
- Neutropenia and Cancer Infections
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Infections and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Social Media in Health Education
- Telemedicine and Telehealth Implementation
- Mycobacterium research and diagnosis
Washington State Department of Health
2015-2025
Museum of Heilongjiang Province
2021
Centers for Disease Control and Prevention
2020
Snohomish Health District
2020
Public Health – Seattle & King County
2020
University of Washington
2020
National Center for Immunization and Respiratory Diseases
2020
Federico II University Hospital
2018
University of California, Davis
1992
BACKGROUND We identified an outbreak of AmpC–producing Escherichia coli infections resistant to third-generation cephalosporins and carbapenems (CR) among 7 patients who had undergone endoscopic retrograde cholangiopancreatography at hospital A during November 2012–August 2013. Gene sequencing revealed a shared novel mutation in bla CMY gene distinctive fumC/ fimH typing profile. OBJECTIVE To determine the extent epidemiologic characteristics outbreak, identify potential sources...
Data on monkeypox in children and adolescents aged <18 years are limited (1,2). During May 17–September 24, 2022, a total of 25,038 cases were reported the United States,† primarily among adult gay, bisexual, other men who have sex with (3). this period, CDC U.S. jurisdictional health departments identified Monkeypox virus (MPXV) infections 83 persons years, accounting for 0.3% cases. Among 28 0–12 monkeypox, 64% boys, most had direct skin-to-skin contact an was caring child household...
Abstract Background Carbapenemase-producing, carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) are extensively drug-resistant bacteria. We investigated the source of a multistate CP-CRPA outbreak. Methods Cases were defined as US patient's first isolation P. sequence type 1203 with carbapenemase gene blaVIM-80 and cephalosporinase blaGES-9 from any specimen collected reported to Centers for Disease Control Prevention during 1 January 2022–15 May 2023. conducted 1:1 matched case-control...
<h3>Objective</h3> To assess the relationship between selected maternal and infant characteristics risk of type 1 diabetes mellitus, specifically identified from birth records that may pertain to hygiene or overload hypotheses. <h3>Design</h3> Population-based case-control study. <h3>Setting</h3> Washington State 1987 2005. <h3>Participants</h3> All children younger than 19 years hospitalized for (<i>International Classification Diseases, Ninth Revision</i>codes 250.x1 250.x3) (n = 1852)...
Abstract In the United States, New Delhi metallo-beta-lactamase (NDM)-producing carbapenem-resistant Enterobacterales (CRE) are frequently associated with healthcare encounters. From September 2021 to 2022, 21 patients NDM-CRE identified from urine and without exposure were reported Centers for Disease Control Prevention. Isolates genetically similar healthcare-associated strains.
was isolated from the Salish Sea (Puget Sound) ecosystem, including samples of marine and fresh water, wildlife dependent on this environment.
Purpose – Antibiotic resistance (AR) is a global health crisis that attracting focussed attention from healthcare, public health, governmental agencies, the public, and food producers. The purpose of this paper to describe work in Washington State combat promote antimicrobial stewardship one perspective. Design/methodology/approach In 2014, Department Health convened One Steering Committee two workgroups focus on AR, Antimicrobial Stewardship group Resistance Surveillance group. organized...
During January 22-March 23, 2018, a local health department in Washington was notified of two patients who received diagnosis acute hepatitis C virus (HCV) infection. Neither patient had behavioral risk factors associated with HCV acquisition; however, both injectable narcotic (opioid) drugs from the same nurse during separate visits to an emergency (ED) at hospital on December 6 and 16, 2017. Investigation revealed that accessed automated drug dispensing system higher frequency than other...
Abstract We describe the contact investigation for an early confirmed case of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), in United States. Contacts case-patient were identified, actively monitored symptoms, interviewed a detailed exposure history, and tested SARS-CoV-2 infection real-time reverse transcription PCR (rRT-PCR) ELISA. Fifty contacts identified 38 (76%) interviewed, whom 11 (29%) reported unprotected face-to-face interaction with...
Abstract Background Management of acute, uncomplicated cystitis in outpatients benefits from knowledge drug resistance patterns the population. However, antibiograms are often not available for outpatient setting, and role host factors such as sex age assessing likelihood well understood. We investigated whether antibiotic urinary Escherichia coli isolates vary by group a large database susceptibility test (AST) results Washington State. Methods retrospectively analyzed AST data E. State...
Abstract Background Historically, United States’ carbapenem-resistant Enterobacterales (CRE) surveillance and mechanism testing focused on three genera: Escherichia, Klebsiella, Enterobacter (EsKE); however, other genera can harbour mobile carbapenemases associated with CRE spread. Objectives From January through May 2018, we conducted a 10 state evaluation to assess the contribution of less common (LCG) carbapenemase-producing (CP) CRE. Methods State public health laboratories (SPHLs)...
The Centers for Disease Control and Prevention (CDC) have outlined core elements of effective antimicrobial stewardship programs (ASPs). However, many smaller community “critical access hospitals” (CAHs) lack resources necessary to fully implement these programs. Tele-antimicrobial is highlighted in the Federal Register as a potential solution such situations. In January 2017 we implemented UW-TASP/ECHO, remotely-based electronic answer problem limited ASPs at CAHs. This interdisciplinary...
Abstract The MITIGATE toolkit was developed to assist urgent care and emergency departments in the development of antimicrobial stewardship programs. At University Washington, we adopted 10 centers, 9 primary clinics, 1 department. We encountered overcame challenges: a complex data build, choosing feasible outcomes measure, issues with accurate coding, maintaining positive relationships. Herein, discuss solutions challenges provide guidance for those considering using this toolkit.
Wound botulism arising from skin and soft tissue infection is rare in children, most cases being reported adult intravenous drug users. Cranial nerve palsies are the primary presenting sign, followed by descending neuromuscular weakness. Diagnosis relies on isolation of either toxigenic Clostridium botulinum species or toxin wound blood samples. We present an unusual case a pediatric patient with intent to inform reader improve time diagnosis such cases.
Antibiotic-resistant E. coli infections represent a major cause of morbidity and mortality pose challenge to antibiotic stewardship. We analyzed large outpatient data set urinary isolates determine whether resistance patterns vary between types practices. Using deidentified from clinical reference laboratory over 5 years logistic regression, we examined the association with practice type, controlling for testing year, patient sex, age. The odds were significantly higher in urology/nephrology...
We appreciate the report by O'Leary et al. 1 summarizing hospitals' progress in implementing antimicrobial stewardship (AS) as tracked National Healthcare Safety Network (NHSN) annual hospital survey.We also support request Ryder for stratification of NHSN survey data facility type and geographic location (e.g., state region) 2 wanted to share our own state-specific findings.Critical access hospitals (CAHs) face unique challenges compared larger acute care (ACHs) 2,3 .Based on efforts...
Background: An overall decrease of prescriptions for outpatient fluoroquinolones (FQs) following the FDA’s release boxed warnings in 2016 was shown a previous analysis1. additional study found that this decline held true when further broken down by specialty 2. We sought to determine which different clinician specialties Washington State (WA) continue prescribe FQs and if these rates are congruent with previously conducted national analyses. Methods: comprehensive analysis Medicare Part D...
Among Washington State emergency and family medicine physicians, high prescribers of opioids were 2.9 times more likely to be antibiotics in the Medicare Part D population. The inverse relationship showed same association. Antimicrobial opioid stewards should collaborate on shared goals implement effective interventions.
Abstract Background: Carbapenem-resistant Enterobacterales (CRE) are common causes of healthcare-associated infections and often multidrug resistant with limited therapeutic options. Additionally, CRE can spread within between healthcare facilities, amplifying potential harms. Objective: To better understand the burden, risk factors, source acquisition carbapenemase genes in clinical Escherichia coli Klebsiella spp isolates from patients Washington to guide prevention efforts. Design:...
Abstract Background Between 15–50% of patients seen in ambulatory settings are prescribed an antibiotic. At least one third this usage is considered unnecessary. In 2019, our institution implemented the MITIGATE Toolkit, endorsed by Centers for Disease Control and Prevention to reduce inappropriate antibiotic prescribing viral respiratory infections emergency urgent care settings. February 2020 we identified first hospitalized patient with SARS-CoV(2). March, efforts limit person-to-person...
Despite proven benefit to mothers and infants, influenza Tdap vaccination for pregnant women remain suboptimal. We conducted an email survey physicians (MDs) licensed midwives (LMs) in Washington assess practices. The State Department of Health University Washington, Obstetrics Gynecology, created electronic sent it 644 providers. used chi-square statistic comparisons, with Fisher’s exact test cell size smaller than 5. received responses from 121 (19%), 106 whom provided prenatal or...