A5015881036- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Antibiotic Resistance in Bacteria
- Helicobacter pylori-related gastroenterology studies
- Vibrio bacteria research studies
- Bacterial Identification and Susceptibility Testing
- Food Security and Health in Diverse Populations
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
Colorado Department of Public Health and Environment
2019-2025
Oregon Medical Research Center
2024
New York Proton Center
2024
University of Pittsburgh
2024
Communities In Schools of Orange County
2024
Lindsay Unified School District
2024
Abstract Objective: Patients tested for Clostridioides difficile infection (CDI) using a 2-step algorithm with nucleic acid amplification test (NAAT) followed by toxin assay are not reported to the National Healthcare Safety Network as laboratory-identified CDI event if they NAAT positive (+)/toxin negative (−). We compared NAAT+/toxin− and NAAT+/toxin+ patients identified factors associated treatment among patients. Design: Retrospective observational study. Setting: The study was conducted...
Abstract Background Active Clostridioides difficile infection (CDI) surveillance is conducted by the U.S. CDC’s Emerging Infections Program (EIP) and includes collection of a convenience sample stool specimens from C. positive cases. Accurate molecular epidemiology relies on recovering clinical specimens. We sought to determine whether CDI diagnostic testing approach was associated with likelihood culturing stool.Table 1.Characteristics collected identified through in Colorado Georgia,...
Because interventions are available to prevent further recurrence in patients with recurrent Clostridioides difficile infection (rCDI), we identified predictors of multiple rCDI (mrCDI) adults at the time presentation initial CDI (iCDI). iCDI was defined as a positive C test any clinical setting during January 2018-August 2019 person aged ≥18 years no known prior test. ≥14 days from previous within 180 after iCDI; mrCDI ≥2 rCDI. We performed multivariable logistic regression analysis. Of 18...
Abstract We evaluated the association between socioeconomic status (SES) and community-associated Clostridioides difficile infection (CA-CDI) incidence across 2474 census tracts in 10 states. Highly correlated community-level SES variables were transformed into distinct factors using factor analysis. found low communities associated with higher CA-CDI incidence.
We evaluated the association between census tract measures of socioeconomic status and Clostridioides difficile infection (CDI) rates in Denver metro area from 2016-2019. Social vulnerability index, poverty, race were associated with CDI. Findings may relate to differences chronic disease prevalence, antibiotic exposure, access quality care.
Abstract Among persons with an initial Clostridioides difficile infection (CDI) across 10 US sites in 2018 compared 2013, 18.3% versus 21.1% had ≥1 recurrent CDI (rCDI) within 180 days. We observed a 16% lower adjusted risk of rCDI 2013 (P < .0001).
The impact of environmental cleaning protocol featuring PX-UV in reducing the incidence multidrug-resistant gram-negative
Abstract Background U.S. laboratories are increasingly using a two-step algorithm to diagnose Clostridioides difficile infection (CDI) that starts with nucleic acid amplification test (NAAT), and if positive, reflexes toxin enzyme immunoassay. Here only NAAT+/toxin+ result is reported the Centers for Disease Control Prevention’s (CDC) National Healthcare Safety Network (NHSN) as CDI laboratory-identified (LabID) event, but limited data suggest NAAT+/toxin- results may also be considered by...
Background: Extended-spectrum β-lactamase–producing (ESBL) Escherichia coli infection incidence is increasing in the United States. This increase may be due to rapid expansion of ST131, which now predominant ESBL strain globally, often multidrug resistant, and has been shown establish longer-term human colonization than other E. strains. We assessed potential risk factors that distinguish ST131 from . Methods: From October 1 through December 31, 2017, 5 CDC Emerging Infections Program (EIP)...
Abstract Background Surveillance of C. difficile infection (CDI), one the most common U.S. healthcare-associated infections, is essential to inform public health response, characterize strains causing disease, and describe changes in strain prevalence over time. The CDC’s Emerging Infections Program (EIP) has conducted active CDI surveillance, including culturing from a convenience sample stool samples cases, since 2009. Cary-Blair transport medium (CBTM) used by some clinical laboratories...
Abstract Background Recent advancements in treating Clostridioides difficile infection (CDI) include therapeutics to prevent further recurrence patients with recurrent CDI (rCDI). However, little is known about which are at increased risk for multiple recurrences (≥ 2 rCDI). We sought identify predictors of rCDI (mrCDI) adults the time presentation initial (iCDI). Methods The Centers Disease Control and Prevention’s Emerging Infections Program (EIP) conducts population-based surveillance 10...
Abstract Background Interventions to reduce community-onset (CO) Clostridioides difficile Infection (CDI) are not usually hospital-based due the perception that they often acquired outside hospital. We determined proportion of admitted CO CDI might be associated with previous hospitalization. Methods The CDC’s Emerging Infections Program conducts population-based surveillance in 10 US sites. defined an incident case as a C. difficile-positive stool collected 2017 from person aged ≥ 1 year...