A5010527305- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Prenatal Substance Exposure Effects
- Neuroscience and Neuropharmacology Research
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Neonatal and fetal brain pathology
- Neurotransmitter Receptor Influence on Behavior
- Cancer Risks and Factors
- Economic and Financial Impacts of Cancer
- Adenosine and Purinergic Signaling
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Cancer survivorship and care
- Advances in Oncology and Radiotherapy
- Receptor Mechanisms and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Birth, Development, and Health
- Cancer Genomics and Diagnostics
- Primary Care and Health Outcomes
- Nerve injury and regeneration
- Global Health and Surgery
- Women's cancer prevention and management
- Cannabis and Cannabinoid Research
Henry Ford Health System
2018-2024
Michigan State University
2024
Henry Ford Health + Michigan State University Health Sciences
2024
Henry Ford Hospital
2020
John D. Dingell VA Medical Center
2007-2018
Wayne State University
2007-2018
University of Michigan
2017
Michigan United
2016
Eugene Applebaum College of Pharmacy and Health Sciences
2008-2009
BackgroundPneumonia and bloodstream infections (BSI) due to extensively drug-resistant (XDR) Acinetobacter baumannii, XDR Pseudomonas aeruginosa, carbapenem-resistant Enterobacterales (CRE) are associated with high mortality rates, therapeutic options remain limited. This trial assessed whether combination therapy colistin meropenem was superior monotherapy for the treatment of these infections.MethodsThe OVERCOME (Colistin Monotherapy versus Combination Therapy) an international,...
Altered alcohol consumption patterns after traumatic brain injury (TBI) can lead to significant impairments in TBI recovery. Few preclinical models have been used examine use across distinct phases of the post-injury period, leaving mechanistic questions unanswered. To address this, aim this study was describe histological and behavioral outcomes a noncontusive closed-head mouse, which sensitivity were quantified, addition dopaminergic signaling markers. We hypothesized that would alter...
Abstract The histone deacetylase (HDAC) inhibitor trichostatin A (TSA) has recently been shown to inhibit deleterious effects of cytokines on β‐cells, but it is unable protect β‐cells from death due its own cytotoxicity. Herein, we investigated novel HDAC inhibitors for their cytoprotective against IL‐1β‐induced damage isolated β‐cells. We report that three compounds (THS‐73–44, THS‐72–5 and THS‐78–5) significantly inhibited activity increased the acetylation H4 in Further, these exerted no...
The histone deacetylase (HDAC) inhibitor trichostatin A (TSA) has recently been shown to inhibit deleterious effects of cytokines on beta-cells, but it is unable protect beta-cells from death due its own cytotoxicity. Herein, we investigated novel HDAC inhibitors for their cytoprotective against IL-1beta-induced damage isolated beta-cells. We report that three compounds (THS-73-44, THS-72-5 and THS-78-5) significantly inhibited activity increased the acetylation H4 in Further, these exerted...
Abstract The cAMP /protein kinase A pathway regulates methamphetamine ( METH )‐induced neuroplasticity underlying behavioral sensitization. We hypothesize that adenylyl cyclases AC ) 1/8 mediate these neuroplastic events and associated striatal dopamine regulation. Locomotor responses to (1 5 mg/kg) function were evaluated in mice lacking DKO wild‐type WT mice. Only mg/kg induced an acute locomotor response mice, which was significantly attenuated versus controls. showed a marked attenuation...
Abstract Histone (de)acetylases control gene transcription via modification of the chromatin structure. Herein, we investigated potential roles for histone deacetylation (or hypoacetylation) in interleukin‐1β (IL‐1β)‐mediated inducible nitric oxide synthase (iNOS) and (NO) release insulin‐secreting INS 832/13 (INS) cells. Western blot analysis suggested localization members Class 1 2 families deacetylases (HDACs) these Trichostatin A (TSA), a known inhibitor HDACs, markedly reduced...
Background Fetal exposure to alcohol can have multiple deleterious effects, including learning disorders and behavioral executive functioning abnormalities, collectively termed fetal spectrum disorders. Neonatal mice lacking both calcium‐/calmodulin‐stimulated adenylyl cyclases ( AC s) 1 8 demonstrate increased vulnerability ethanol (EtOH)‐induced neurotoxicity in the striatum compared with wild‐type WT ) controls. However, developmental impact on surviving neurons is still unclear. Methods...
Impaired striatal neuroplasticity may underlie increased alcoholism documented in those with posttraumatic stress disorder (PTSD). Cannabinoid receptor-1 (CB1) is sensitive to the effects of ethanol (EtOH) and traumatic stress, a critical regulator plasticity. To investigate CB1 involvement PTSD-alcohol interaction, this study measured using model PTSD, mouse single-prolonged (mSPS), on EtOH-induced locomotor sensitization levels.
Background Breast cancer mortality rates are 39% higher in the African-American (AA) women compared to White-American (WA) despite advances overall breast screening and treatments. Several studies have undertaken identify factors leading this disparity United States with possible effects of lower socioeconomic status underlying aggressive biology. Methods A retrospective analysis was done using a prospectively maintained database metropolitan health system. Patients were selected based on...
Neuroadaptive responses to chronic ethanol, such as behavioral sensitization, are associated with <i>N</i>-methyl-D-aspartate receptor (NMDAR) recruitment. Ethanol enhances GluN2B-containing NMDAR function and phosphorylation (Tyr-1472) of the GluN2B-NMDAR subunit in dorsal medial striatum (DMS) through a protein kinase A (PKA)–dependent pathway. Ethanol-induced PKA substrates is partially mediated by calcium-stimulated adenylyl cyclase 1 (AC1), which enriched striatum. As such, AC1 poised...
Evidence suggests a predictive link between elevated basal activity within reward-related networks (e.g., cortico-basal ganglia-thalamic networks) and vulnerability for alcoholism. Both calcium channel function cyclic adenosine monophosphate (cAMP)/protein kinase A-mediated signaling are critical modulators of reward neurocircuitry behaviors. Calcium/calmodulin-stimulated adenylyl cyclases (AC) 1 8 sensitive to activity-dependent increases in intracellular catalyze cAMP production....
The optimal structure for survivorship care plan (SCP) programs and methodology generating treatment summaries (TSs) has not yet been defined, but the Commission on Cancer National Accreditation Program Breast Centers both mandate that participating oncology implement SCP-TS processes patients have completed treatment.We used Institute Healthcare Improvement's Plan-Do-Study-Act model conducting a quality improvement project evaluating two different implemented at Henry Ford Health...
This study analyzes a survey conducted at gathering of clinicians who specialize in breast cancer sub-Saharan Africa to better understand what they need from international collaborators.
We evaluated 328 patients (34.8% African American [AA]; 65.2% White [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA WA, respectively) were similar, BMI was higher (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution similar- 8.3% 5.9% WA high RS (≥31). No significant differences observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months 33.4 distant recurrence occurred...
Abstract Objective We aimed to describe preliminary dietary intake results using DietID ™ for assessment during pregnancy. A sub-sample of participants in the Research Enterprise Advance Children’s Health (REACH) prospective birth cohort from Detroit, MI received a unique web link complete multiple times present first completed pregnancy by each participant. uses an image-based algorithm estimate nutrient intake, patterns, and diet quality provides immediate participants. Descriptive...
Navigating health and social care in the United States can be difficult for people of all ages, but older adults often have multiple problems, chronic illnesses, disabilities that increase complexities their care. To assist adult patients and/or caregivers with coordinating care, providing information, advocacy, resources, Henry Ford Health (HFH) implemented a Senior Care Navigation Program (SCNP). Older HFH or were referred to SCNP either by provider another member team. A senior navigator...