A5005026426- Neurotransmitter Receptor Influence on Behavior
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Eating Disorders and Behaviors
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Diet and metabolism studies
- Obsessive-Compulsive Spectrum Disorders
- Species Distribution and Climate Change
- Obesity, Physical Activity, Diet
- Attention Deficit Hyperactivity Disorder
- Hypothalamic control of reproductive hormones
- Nicotinic Acetylcholine Receptors Study
- Primate Behavior and Ecology
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- CRISPR and Genetic Engineering
- Animal Vocal Communication and Behavior
- Neural and Behavioral Psychology Studies
- Schizophrenia research and treatment
University of Michigan
2015-2024
Michigan United
2012-2022
Wayne State University
2017
John D. Dingell VA Medical Center
2017
Regional West Medical Center
2015
Rosalind Franklin University of Medicine and Science
2009-2012
Franklin University
2009-2010
Urges to eat are influenced by stimuli in the environment that associated with food (food cues). Obese people more sensitive cues, reporting stronger craving and consuming larger portions after cue exposure. The nucleus accumbens (NAc) mediates cue-triggered motivational responses, activations NAc triggered cues who susceptible obesity. This has led idea alterations function similar those underlying drug addiction may contribute obesity, particularly obesity-susceptible individuals....
Quantifying animal behavior is important for biological research. Identifying behaviors the prerequisite of quantifying them. Current computational tools behavioral quantification typically use high-level properties such as body poses to identify behaviors, which constrains information available a holistic assessment. Here we report
Microdialysis sampling was coupled on-line to micellar electrokinetic chromatography (MEKC) monitor extracellular dopamine concentration in the brains of rats. probes were perfused at 0.3 μL/min and dialysate mixed with 6 mM naphthalene-2,3-dicarboxaldehye 10 potassium cyanide pumped 0.12 each into a reaction capillary. The mixture delivered flow-gated interface separated 90-s intervals. MEKC separation buffer consisted 30 phosphate, 6.5 SDS, 2 HP-β-CD pH 7.4, electric field 850 V/cm applied...
The spread of certain diseases can be promoted, in some cases substantially, by prior infection with another disease. One example is that HIV, whose immunosuppressant effects significantly increase the chances other pathogens. Such coinfection processes, when combined nontrivial structure contact networks over which spread, lead to complex patterns epidemiological behavior. Here we consider a mathematical model two spreading through single population, where one disease dependent on other. We...
Brain-derived neurotrophic factor (BDNF) contributes to diverse types of plasticity, including cocaine addiction. We investigated the role BDNF in rat nucleus accumbens (NAc) incubation craving over 3 months withdrawal from extended access self-administration. First, we confirmed by immunoblotting that levels are elevated after this regimen on day 45 (WD45) and showed mRNA not altered. Next, explored time course expression using immunohistochemistry. Elevation NAc core was detected WD45...
Studies in humans suggest that stronger incentive motivational responses to Pavlovian food cues may drive over-consumption leading and maintaining obesity, particularly susceptible individuals. However, whether this enhanced motivation emerges as a consequence of obesity or rather precedes is unknown. Moreover, while human imaging studies have provided important information about differences striatal responsiveness between non-susceptible individuals, the neural mechanisms mediating these...
Abstract The amygdala is an essential neural substrate for Pavlovian fear conditioning. Nevertheless, long‐term synaptic plasticity in amygdaloid afferents, such as the auditory thalamus, may contribute to formation of memories. We therefore compared influence protein synthesis inhibition and thalamus on consolidation conditioning Long–Evans rats. Rats received three tone‐footshock trials a novel chamber. Immediately after conditioning, rats were infused intra‐cranially with inhibitor,...
Behavioral sensitization is an animal model for aspects of cocaine addiction. Cocaine-sensitized rats exhibit increased AMPA receptor (AMPAR) surface expression in the nucleus accumbens (NAc) which may turn enhance drug seeking. To identify signaling pathways contributing to AMPAR up-regulation, we measured and pathway activation NAc cocaine-sensitized rats, cocaine-exposed that failed sensitize saline controls on withdrawal days (WD) 1, 7, 21. We focused calcium/calmodulin-dependent protein...
Abstract Trafficking of neurotransmitter receptors between intracellular and cell surface compartments is important for regulating neurotransmission. We developed a method determining if an in vivo treatment has altered receptor distribution particular region rodent brain. After the treatment, brain slices are rapidly prepared from interest. Then, surface–expressed proteins covalently cross‐linked using membrane‐impermeable, bifunctional cross‐linker bis(sulfosuccinimidyl)suberate (BS 3 )....
Naturally occurring alterations in estradiol influence food intake females. However, how motivational responses to cues are affected by the estrous cycle or ovarian hormones is unknown. In addition, while individual susceptibility obesity accompanied enhanced incentive and increased NAc intrinsic excitability males, studies females absent. Therefore, we examined basal differences of obesity-prone vs. obesity-resistant determined conditioned approach (a measure cue-triggered motivation),...
Human fMRI studies show that insulin influences brain activity in regions mediate reward and motivation, including the nucleus accumbens (NAc). Insulin receptors are expressed by NAc medium spiny neurons (MSNs), of cultured cortical hippocampal suggest excitatory transmission via presynaptic postsynaptic mechanisms. However, nothing is known about how NAc. Furthermore, dysregulation accompanying obesity linked to cognitive decline, depression, anxiety, altered motivation rely on...
ABSTRACT Analyzing social behaviors is critical for many fields, including neuroscience, psychology, and ecology. While computational tools have been developed to analyze videos containing animals engaging in limited interactions under specific experimental conditions, automated identification of the roles freely moving individuals a multi-animal group remains unresolved. Here we describe deep-learning-based system – named LabGym2 identifying quantifying groups. This uses subject-aware...