Frank-Rainer Klefisch

ORCID: 0000-0003-4064-7768
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About
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Research Areas
  • Intensive Care Unit Cognitive Disorders
  • Family and Patient Care in Intensive Care Units
  • Antifungal resistance and susceptibility
  • Fungal Infections and Studies
  • Acute Myocardial Infarction Research
  • Enterobacteriaceae and Cronobacter Research
  • Infective Endocarditis Diagnosis and Management
  • Nail Diseases and Treatments
  • Medical Device Sterilization and Disinfection
  • Antibiotic Resistance in Bacteria
  • Cardiovascular Effects of Exercise
  • Cardiac Imaging and Diagnostics
  • Health, psychology, and well-being
  • Nosocomial Infections in ICU
  • Antimicrobial Resistance in Staphylococcus
  • Adipokines, Inflammation, and Metabolic Diseases
  • Asthma and respiratory diseases
  • Hemodynamic Monitoring and Therapy
  • Mycobacterium research and diagnosis
  • Emergency and Acute Care Studies
  • Sepsis Diagnosis and Treatment
  • Psychiatric care and mental health services
  • Viral Infections and Immunology Research
  • Venous Thromboembolism Diagnosis and Management
  • Pneumocystis jirovecii pneumonia detection and treatment

University Medical Center Hamburg-Eppendorf
2025

Universität Hamburg
2025

München Klinik
2025

LMU Klinikum
2025

Ludwig-Maximilians-Universität München
2025

Schön Klinik Bad Aibling
2025

Sana Klinikum
2024

Unfallkrankenhaus Berlin
2019

Charité - Universitätsmedizin Berlin
2000-2004

Humboldt-Universität zu Berlin
1997-2000

Carbapenem-resistant Enterobacteriaceae (CRE) cause health care-associated infections worldwide, and they are of severe concern due to limited treatment options. We report an outbreak KPC-2-producing CRE that was caused by horizontal transmission a promiscuous plasmid across different genera bacteria hospitals in Germany. Eleven isolates (8 Citrobacter freundii, 2 Klebsiella oxytoca, 1 Escherichia coli) were obtained from seven critically ill patients during the six months 2016. One patient...

10.3389/fmicb.2019.00276 article EN cc-by Frontiers in Microbiology 2019-02-19

Fluconazole-resistant Candida parapsilosis has emerged as a significant health-care-associated pathogen with propensity to spread patient and cause nosocomial outbreaks, similar auris. This study investigates long-lasting outbreak of fluconazole-resistant C that was initially detected in December, 2018, January, 2019, officially declared November, 2019; lasted multiple years; involved several health-care centres Berlin, Germany.

10.1016/j.lanmic.2024.07.012 article EN cc-by The Lancet Microbe 2024-11-01
Antina Beutel Linda Sanftenberg Chris M. Friemel Robert P. Kosilek Maggie Schauer and 95 more Thomas Elbert Ulf‐Dietrich Reips Tomke Schubert Sabine Gehrke-Beck Konrad Schmidt Jochen Gensichen Christine Adrion Matthias Angstwurm Antje Bergmann Gerhard Bielmeier Andrea Bischhoff Ralph Bogdanski Franz Brettner Christian Brettschneider Josef Briegel Martin Bürkle Johanna Dohmann Peter Falkai Thomas W. Felbinger Richard Fisch Hans Förstl Benjamin Fohr Martin Franz Patrick Friederich Jürgen Gallinat Herwig Gerlach Andreas Güldner Hanna Hardt Christoph Heintze Andreas Heinz Axel R. Heller Christian von Heymann Petra Hoppmann Volker Huge Michael Irlbeck Ulrich Jaschinski Dominik Jarczak Stefanie Joos Elisabeth Kaiser Melanie Kerinn Frank-Rainer Klefisch Stefan Kluge Roland Koch Thea Koch Michelle Kowalski Hans‐Helmut König Robert P. Kosilek Peter Lackermeier Karl‐Ludwig Laugwitz Tri Le Yvonne Lemke Achim Lies Klaus Linde Daniela Lindemann Dagmar Lühmann S. W. MAY Ludwig Ney Jan Hendrik Oltrogge Wulf Pankow Sergi Papiol Maximilian Ragaller Nikolaus Rank Lorenz Reill Hans‐Peter Richter Reimer Rießen Grit Ringeis Ann Rüchhardt Gustav Schelling Jörg Schelling André Scherag Martin Scherer Antonius Schneider Gerhard Schneider Jürgen Schneider Julia Schnurr Susanne Schultz Thomas G. Schulze Karin Schumacher John Singhammer Peter M. Spieth K. Theisen Franka Thurm Thomas P. Vogl Karen Voigt Andreas Walther Dietmar Wassilowsky Cornelia Wäscher Regina Wehrstedt Björn Weiß Roland Weierstall‐Pust Marion Weis G. Weiß Harald Well Zöllner Christian Bernhard Zwißler

Abstract Background Approximately 20–25% of patients who survive medical treatment at an intensive care unit (ICU) develop post-traumatic stress symptoms. There is currently a gap in follow-up for them. As part the PICTURE study, general practitioners (GPs) carried out brief interview-based intervention. The aim this sub-study to record most distressing memories ICU from patient’s perspective and their evaluation GP-based psychological Methods Participants were recruited intervention group...

10.1186/s12875-024-02698-6 article EN cc-by BMC Primary Care 2025-01-15

Summary Background Fluconazole-resistant Candida parapsilosis has emerged as a significant healthcare-associated pathogen with propensity to spread patient-to-patient and cause nosocomial outbreaks, similar auris . This study investigates prolonged outbreak of fluconazole-resistant C. across multiple years healthcare centers in Berlin, Germany. Methods In this retrospective observational study, we used whole-genome sequencing isolates from the Berlin other regions within Germany compared...

10.1101/2024.02.22.24302918 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2024-02-24
Linda Sanftenberg Antina Beutel Chris M. Friemel Robert P. Kosilek Maggie Schauer and 92 more Thomas Elbert Ulf‐Dietrich Reips Sabine Gehrke-Beck Tomke Schubert Konrad Schmidt Jochen Gensichen Christine Adrion Matthias Angstwurm Antje Bergmann Gerhard Bielmeier Andrea Bischhoff Ralph Bogdanski Franz Brettner Christian Brettschneider Josef Briegel Martin Bürkle Johanna Dohmann Peter Falkai Thomas W. Felbinger Richard Fisch Hans Förstl Benjamin Fohr Martin Franz Patrick Friederich Chris M. Friemel Jürgen Gallinat Herwig Gerlach Andreas Güldner Hanna Hardt Christoph Heintze Andreas Heinz Axel R. Heller Christian von Heymann Petra Hoppmann Volker Huge Michael Irlbeck Ulrich Jaschinski Dominik Jarczak Stefanie Joos Elisabeth Kaiser Melanie Kerinn Frank-Rainer Klefisch Stefan Kluge Roland Koch Thea Koch Michelle Kowalski Hans-Helmut König Peter Lackermeier Karl‐Ludwig Laugwitz Yvonne Lemke Achim Lies Klaus Linde Daniela Lindemann Dagmar Lühmann S. W. MAY Ludwig Ney Jan Hendrik Oltrogge Wulf Pankow Sergi Papiol Maximilian Ragaller Nikolaus Rank Lorenz Reill Hans‐Peter Richter Reimer Rießen Grit Ringeis Ann Rüchhardt Gustav Schelling Jörg Schelling André Scherag Martin Scherer Antonius Schneider Gerhard Schneider Jürgen Schneider Julia Schnurr Susanne Schultz Thomas G. Schulze Karin Schumacher Peter M. Spieth Franka Thurm Thomas P. Vogl Karen Voigt Andreas Walther Dietmar Wassilowsky Cornelia Wäscher Steffen Weber‐Carstens Regina Wehrstedt Roland Weierstall‐Pust Marion Weis G. Weiß Harald Well Christian Zöllner Bernhard Zwißler

The results of critical illness and life-saving invasive measures during intensive care unit treatment can sometimes lead to lasting physical psychological impairments. A multicentre randomized controlled trial from Germany (PICTURE) aims test a brief intervention, based on narrative exposure therapy, for post-traumatic stress disorder symptoms following in the primary setting. qualitative analysis was conducted understand feasibility acceptance intervention beyond quantitative main outcomes...

10.1186/s12875-023-02046-0 article EN cc-by BMC Primary Care 2023-05-06

Background: The clinical significance of the detection Candida albicans on mucous membranes respiratory or intestinal tract from patients in intensive care units is still not finally clarified. Many reveal colonization, although, despite increased risk, there are only a few invasive infections detectable. Therefore, antimycotic therapy this setting strongly discouraged. In reality, however, many receive antimycotics as pre-emptive therapy. To elucidate point, literature research was...

10.4236/pp.2011.24046 article EN cc-by Pharmacology &amp Pharmacy 2011-01-01
Linda Sanftenberg Julia Krevet Robert P. Kosilek Daniela Lindemann Konrad Schmidt and 95 more Christoph Heintze Thomas Elbert Maggie Schauer Ulf‐Dietrich Reips Jochen Gensichen Christine Adrion Matthias Angstwurm Cora Ballmann Antje Bergmann Antina Beutel Gerhard Bielmeier Andréa Bischoff Ralph Bogdanski Franz Brettner Christian Brettschneider Josef Briegel Martin Bürkle Johanna Dohmann Thomas Elbert Peter Falkai Thomas W. Felbinger Richard Fisch Hans Förstl Benjamin Fohr Martin Franz Patrick Friederich Chris-Maria Friemel Jürgen Gallinat Sabine Gehrke-Beck Jochen Gensichen Herwig Gerlach Andreas Güldner Hanna Hardt Christoph Heintze Andreas Heinz Axel R. Heller Christian von Heymann Petra Hoppmann Volker Huge Michael Irlbeck Ulrich Jaschinski Dominik Jarczak Stefanie Joos Elisabeth Kaiser Melanie Kerinn Frank-Rainer Klefisch Stefan Kluge Roland Koch Thea Koch Michelle Kowalski Hans-Helmut König Robert P. Kosilek Peter Lackermeier Karl‐Ludwig Laugwitz Yvonne Lemke Achim Lies Klaus Linde Daniela Lindemann Dagmar Lühmann S. W. MAY Ludwig Ney Jan Hendrik Oltrogge Wulf Pankow Sergi Papiol Maximilian Ragaller Nikolaus Rank Lorenz Reill Ulf‐Dietrich Reips Hans‐Peter Richter Reimer Rießen Grit Ringeis David Rösgen Ann Rüchhardt Linda Sanftenberg Maggie Schauer Gustav Schelling Jörg Schelling André Scherag Martin Scherer Tomke Schubert Konrad Schmidt Antonius Schneider Gerhard Schneider Jürgen Schneider Julia Schnurr Susanne Schultz Thomas G. Schulze Karin Schumacher Peter M. Spieth Franka Thurm Thomas P. Vogl Karen Voigt Andreas Walther Dietmar Wassilowsky Cornelia Wäscher

Zusammenfassung Hintergrund Intensivmedizinische Aufenthalte führen bei vorbelasteten Menschen häufig zu Symptomen einer posttraumatischen Belastungsstörung (Post-ICU-PTBS). In der Nachsorge spielen HausärztInnen eine wichtige Rolle. Falldarstellung Eine 58-jährige Patientin entwickelt nach erlebter Sepsis Post-ICU-PTBS. Sie erhält durch ihre Hausärztin Kurzform Narrativen Expositionstherapie (NET) und erfährt deutliche Symptombesserung. Schlussfolgerung Die angewandte NET kann für die...

10.1007/s44266-023-00167-4 article DE cc-by Zeitschrift für Allgemeinmedizin 2024-01-25

Abstract Background For clinicians treating patients with infective endocarditis (IE), identifying the causative microorganisms poses a critical diagnostic challenge. Standard techniques including blood and heart valve cultures often yield inconclusive results. According to recent 2023 Duke-ISCVID Criteria, molecular methods represent potent tools enhance this aspect of IE diagnostics guide subsequent therapeutic strategies. Methods We retrospectively analyzed data from 124 consecutive who...

10.1093/ofid/ofae716 article EN cc-by-nc-nd Open Forum Infectious Diseases 2024-12-10

Key words Superoxide - bronchial asthma oxidative stress spirometry hyperreactivity

10.1055/s-2008-1061876 article EN Physikalische Medizin Rehabilitationsmedizin Kurortmedizin 1997-08-01

Eichstaedt, H. W.; Danne, O.; Moeckel, M.; Klefisch, F.; Amthauer, H.; Jochens, R.; Moersler, J.; Schumacher, T.; Stoerk, T. Author Information

10.1097/00006231-199704000-00167 article EN Nuclear Medicine Communications 1997-04-01
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