Daniel Thomas-Rüddel
A5030902987- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Antifungal resistance and susceptibility
- Long-Term Effects of COVID-19
- Emergency and Acute Care Studies
- Clinical practice guidelines implementation
- Vitamin C and Antioxidants Research
- Neonatal and Maternal Infections
- Traumatic Brain Injury and Neurovascular Disturbances
- Clinical Reasoning and Diagnostic Skills
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Health Systems, Economic Evaluations, Quality of Life
- Spectroscopy Techniques in Biomedical and Chemical Research
- Airway Management and Intubation Techniques
- Healthcare cost, quality, practices
Jena University Hospital
2014-2024
Friedrich Schiller University Jena
2012-2023
University Medical Center
2019
Charité - Universitätsmedizin Berlin
2019
German Center for Lung Research
2016
Medizinische Hochschule Hannover
2016
Dr. A. Ramachandran's Diabetes Hospitals
2016
University of Freiburg
2004
Background: Sepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around world.To date, adequate data on incidence and mortality sepsis in Germany have been lacking.Methods: Nationwide case-related hospital DRG statistics for years 2007-2013 were used determine in-hospital sepsis.Cases identified basis clinical pathogen-based ICD-10 codes sepsis.The statistical evaluation was standardized age sex carried out separately each group.Results:...
Abstract Introduction Current sepsis guidelines recommend antimicrobial treatment (AT) within one hour after onset of sepsis-related organ dysfunction (OD) and surgical source control 12 hours. The objective this study was to explore the association between initial infection management according recommendations patient outcome. Methods In a prospective observational multi-center cohort in 44 German ICUs, we studied 1,011 patients with severe or septic shock regarding times AT, control,...
This study aimed to evaluate the accuracy of procalcitonin (PCT) serum concentrations diagnose Gram-negative bacteremia and association PCT with more specific pathogens focus infection. Secondary analysis prospectively collected patient-level dataset from a cluster randomized quality improvement trial was performed. The included sepsis patients organ dysfunction treated in participating intensive care units 2011 2015. Test performance for prediction assessed by receiver operating curve...
Objectives: Perceiving nonbeneficial treatment is stressful for ICU staff and may be associated with burnout. We aimed to investigate predictors consequences of perceived compare nurses junior senior physicians. Design: Cross-sectional, multicenter paper-pencil survey on personal work-related characteristics, treatment, burnout, intention leave the job. Setting: Convenience sample 23 German ICUs. Subjects: Interventions: None. Measurements Main Results: A total 847 questionnaires were...
Abstract Background Timely antimicrobial treatment and source control are strongly recommended by sepsis guidelines, however, their impact on clinical outcomes is uncertain. Methods We performed a planned secondary analysis of cluster-randomized trial conducted from July 2011 to May 2015 including forty German hospitals. All adult patients with treated in the participating ICUs were included. Primary exposures timing therapy delay surgical during first 48 h after onset. endpoint was 28-day...
Rationale: Diaphragm dysfunction is frequently observed in critically ill patients with difficult weaning from mechanical ventilation. Objectives: To evaluate the effects of temporary transvenous diaphragm neurostimulation on outcome and maximal inspiratory pressure. Methods: Multicenter, open-label, randomized, controlled study. Patients aged ⩾18 years invasive ventilation for ⩾4 days having failed at least two attempts received using a multielectrode stimulating central venous catheter...
Introduction Administrative data are used to generate estimates of sepsis epidemiology and can serve as source for quality indicators. Aim was compare on incidence mortality based different ICD-code abstraction strategies assess their validity case identification a patient sample not pre-selected presence codes. Materials methods We the national DRG-statistics assessment population-level mortality. Cases were identified by three previously published International Statistical Classification...
Abstract Background Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates. Methods We did a secondary analysis of large clinical dataset from quality improvement trial. A binary logistic regression model was calculated assess the association thermal response with outcome multinomial factors associated fever or hypothermia. Results With 6542 analyzable cases we bimodal temperature characterized by hypothermia, normothermia...
To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk invasive Candida infection (ICI). Multicenter, randomized, controlled trial carried out between September 2016 2019 in 18 intensive care units enrolling adult at for ICI. Patients the control group received targeted driven by culture results. In addition therapy, BDG antifungals if least one two consecutive samples taken during first...
Germany has more intensive care unit (ICU) beds per capita than the USA, but utilization of these resources at end life is unknown.
This study assessed differences in interprofessional collaboration, perception of nonbeneficial care, and staff well-being between critical care palliative teams. In six German hospitals, a survey was conducted December 2013 March 2015 among nurses physicians intensive units. To allow comparability unit types, matching performed for demographic characteristics staff. N = 313 79 participated, which 72 each were successfully matched. Critical perceived the poorest overall quality collaboration...
Disease heterogeneity in coronavirus disease 2019 (COVID-19) may render the current one-size-fits-all treatment approach suboptimal. We aimed to identify and immunologically characterize clinical phenotypes among critically ill COVID-19 patients, assess of corticosteroid effect. applied consensus k-means clustering on 21 parameters obtained within 24 h after admission intensive care unit (ICU) from 13,279 patients admitted 82 Dutch ICUs February 2020 2022. Derived were reproduced 6225 ICU...
Abstract Background Stress hyperglycaemia (SHG) is a common complication in sepsis associated with poor outcome. Chemerin an adipocytokine inflammation and impaired glucose homeostasis metabolic diseases such as type 2 diabetes (T2D). We aimed to investigate how alterations of circulating chemerin levels corresponding visceral adipose tissue (VAT) expression are linked metabolism prognosis sepsis. Methods Clinical data samples were taken from cross-sectional study including control, T2D...
OBJECTIVES: Worldwide, more than half of all sepsis cases occur in pediatric and adolescent patients, particularly neonates. Previous population-based studies these age groups often were limited to either neonatal or patients admitted ICUs. We aimed investigate the overall age-specific incidence case fatality children Germany, a high-income country with total population 82 million. DESIGN: Retrospective observational study based on German Diagnosis-related Groups statistics years 2010–2016....
Objectives: Leukocytes are first responders to infection. Their activation state can reveal information about specific host immune response and identify dysregulation in sepsis. This study aims use the Raman spectroscopic fingerprints of blood-derived leukocytes differentiate inflammation, infection, sepsis hospitalized patients. Diagnostic sensitivity specificity shall demonstrate added value direct characterization leukocyte’s phenotype. Design: Prospective nonrandomized, single-center,...