A5078627364- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Chronic Myeloid Leukemia Treatments
- Pharmacological Effects of Natural Compounds
- Sarcoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Ginseng Biological Effects and Applications
- Pathogenesis and Treatment of Hiccups
- Complementary and Alternative Medicine Studies
- Cancer Treatment and Pharmacology
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Neurofibromatosis and Schwannoma Cases
- Cancer Immunotherapy and Biomarkers
- IgG4-Related and Inflammatory Diseases
- Herbal Medicine Research Studies
- Pancreatitis Pathology and Treatment
- Acute Kidney Injury Research
- Gastrointestinal motility and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Effects of Radiation Exposure
- Cancer Genomics and Diagnostics
- Ginger and Zingiberaceae research
Universitätsmedizin Göttingen
2015-2024
University of Göttingen
2013-2023
Sheffield Teaching Hospitals NHS Foundation Trust
2023
Novartis (United States)
2013
Bayreuth Medical Center
2012
Endokrinologikum
2007
Endocrinology Research Center
2005
Bridge University
2005
Royal Perth Hospital
1974
American Medical Association
1974
Little is known about whether the duration of adjuvant imatinib influences prognostic significance KIT proto-oncogene receptor tyrosine kinase (KIT) and platelet-derived growth factor α (PDGFRA) mutations.To investigate effect PDGFRA mutations on recurrence-free survival (RFS) in patients with gastrointestinal stromal tumors (GISTs) treated surgery imatinib.This exploratory study based Scandinavian Sarcoma Group VIII/Arbeitsgemeinschaft Internistische Onkologie (SSGXVIII/AIO) multicenter...
<h3>Importance</h3> Adjuvant imatinib is associated with improved recurrence-free survival (RFS) when administered after surgery to patients operable gastrointestinal stromal tumor (GIST), but its influence on overall (OS) has remained uncertain. <h3>Objective</h3> To evaluate the effect of adjuvant OS who have a high estimated risk for GIST recurrence macroscopically complete surgery. <h3>Design, Setting, and Participants</h3> In this open-label, randomized (1:1), multicenter phase 3...
Context: Carney triad (CT) describes the association of paragangliomas (PGLs) with gastrointestinal stromal tumors (GISTs) and pulmonary chondromas. Inactivating mutations mitochondrial complex II succinate dehydrogenase (SDH) enzyme subunits SDHB, SDHC, SDHD are found in PGLs, gain-of-function c-kit (KIT), platelet-derived growth factor receptor A (PDGFRA) GISTs. Objective: Our objective was to investigate possibility that patients CT and/or their may harbor SDHD, KIT, PDGFRA genes identify...
The liver is the largest parenchymatous organ of body and central for intermediate metabolism. Its close contact to portal blood streaming back from gut systemic circulation a prerequisite various processes ongoing on cellular level. spatial relationship hepatocytes with different structures liver, such as fenestrated sinusoidal endothelial cells, Kupffer bile canaliculi important organization performance metabolism nutrients (proteins, glucose fatty acids), clearance toxic or infectious...
Objective Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis—Microbiome As Predictor Severity; P-MAPS) early at hospital admission. Design Buccal and rectal microbial swabs were collected from 424 patients with within 72 hours admission 15 European centres. All samples sequenced by full-length 16S rRNA metagenomic sequencing using Oxford Nanopore Technologies. Primary endpoint was...
The duodenum as primary site for gastrointestinal stromal tumors (GISTs) is rare and mitotic rate, tumor size, type of mutation number chromosomal aberrations have prognostic implications.We analyzed the outcome 13 patients with duodenal GISTs who underwent surgical resection. Either segmental duodenectomy or pylorus-preserving duodenopancreatectomy was performed. were histopathologically examined risk progression assessed based on size count. Additionally, analysis KIT PDGFRA receptor...
Single-dose thioacetamide (TAA) administration induces inflammation and acute liver damage. The mechanism of inflammatory cell recruitment in the is still unclear. aim this study was to examine sequence cells different regions relation CXC- CC-chemokine cytokine expression during injury. TAA administered rats intraperitoneally, animals were killed at time points thereafter. Serum tissue taken frozen immediately. Tissue used for immunostaining cryostat sections, RNA, protein extraction....
Capsule endoscopy (CE) opened a new method for visualization of the small intestine. We here further explore its clinical implications. retrospectively analyzed benefit CE in view medical history, diagnostics, and therapy. Our patient collective consisted 203 patients. was investigated context bleeding, anemia, abdominal pain, diarrhea, Crohn's disease, suspected tumors. The study 118 male 85 female patients with mean age 58 years (range 8–90 years). Complete bowel transit took place 82%...
Limited data are available about the influence of KIT and PDGFRA mutations on overall survival (OS) patients with gastrointestinal stromal tumor (GIST) treated adjuvant imatinib.The Scandinavian Sarcoma Group XVIII/AIO multicenter trial accrued 400 a high risk for GIST recurrence after macroscopically complete surgery between February 4, 2004, September 29, 2008. The received imatinib mg/day either 1 year or 3 years based random allocation. We analyzed using conventional sequencing centrally...
Abstract Background Patients with ruptured gastrointestinal stromal tumour (GIST) have poor prognosis. Little information is available about how adjuvant imatinib influences survival. Methods We explored recurrence-free survival (RFS) and overall (OS) of patients GIST who participated in a randomised trial (SSG XVIII/AIO), where 400 high-risk were allocated to for either 1 year or 3 years after surgery. Of the 358 confirmed localised GIST, 73 (20%) had rupture reported. The ruptures...
Although BCR-ABL1 tyrosine kinase inhibitors reliably induce disease remission for patients with chronic myeloid leukaemia (CML), unlimited extension of therapy is necessary to prevent relapse from persistent leukaemic cells. Here, we analysed model cell lines and primary CML cells the expression functions ABC transporter A3 (ABCA3) as well embryonic stem cell-associated transcription factor SALL4. ABCA3 protected cytotoxic effects imatinib, dasatinib, nilotinib. In surviving cells, exposure...
Objectives: Loss-of-function mutations in TP53 and CDKN2A have been found at varying frequencies gastrointestinal stromal tumors (GISTs), while no of RB1 reported to date. The aim the current study was determine mutation frequency TP53, RB1, GISTs. Methods: A cohort 83 primary untreated GISTs analyzed for by massive parallel sequencing. Tumors with were fluorescence situ hybridization corresponding gene loci. Results: Two harbored inactivating two other displayed TP53. All four KIT mutant...
Introduction Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of gastrointestinal tract. They regarded as having relatively uniform histology, although their potential for malignant behavior varies. Despite a strong promoting role tumor-infiltrating innate immune cells in neoplastic progression, presence GISTs has not yet been studied. Methods A total 47 untreated, c-kit-positive primary were immunohistochemically analyzed to distinguish histiocytic and dendritic (DCs)...
Loss of chromosome 9p is a reliable predictor malignant behaviour in gastrointestinal stromal tumours (GISTs). p16INK4A located at 9p21 inhibits the CDK4/6/cyclin D complex from phosphorylating RB. Phosphorylation RB through early G(1) phase frees transcription factor E2F1 and enables mRNA genes essential for G(1)/S transition. This study aims to determine impact loss on protein expression further key cell cycle regulators different phases cycle. Sixty primary GISTs previously characterized...
Objectives: Trough total imatinib (t-IM) concentrations have been reported to be associated with therapeutic and toxic responses in patients chronic myelogenous leukemia (CML) gastrointestinal stromal tumor (GIST). Little is known about the relationships between effects of either unbound (f-IM) or imatinib's major metabolite, N-desmethyl (NDI). In part, this because lack a single, validated, well-described clinically useful assay for these measurements. The authors report development...
Hereditary hemorrhagic telangiectasia is characterized by mucocutaneous and visceral involves several organs with vascular malformations. It an autosomal dominant disease distinguished into three types, which are due to mutations in different genes. The common symptom anemia, causing a continous need of blood transfusion. Depending on the severity manifestation, there various forms therapy ranging from local activities operations or drug therapy. Here we describe dramatic improvement patient...
Gastrointestinal stromal tumors (GISTs) have distinct gene expression patterns according to localization, genotype and aggressiveness. DNA methylation at CpG dinucleotides is an important mechanism for regulation of expression. We performed targeted analysis 1.505 loci in 807 cancer‐related genes a cohort 76 GISTs, combined with genome‐wide mRNA 22 identify signatures associated clinicopathological parameters prognosis. Principal component revealed anatomical genotype, mitotic counts...