A5047589734- HIV/AIDS Research and Interventions
- Pancreatic function and diabetes
- Advanced Text Analysis Techniques
- Syphilis Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Reproductive tract infections research
- HIV/AIDS drug development and treatment
- Apelin-related biomedical research
- Epigenetics and DNA Methylation
- Computational and Text Analysis Methods
- COVID-19 Impact on Reproduction
- Liver physiology and pathology
- HIV Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Pharmacological Effects and Toxicity Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Cells and Metastasis
- Immunotoxicology and immune responses
- Toxin Mechanisms and Immunotoxins
- COVID-19 epidemiological studies
- Information Technology Governance and Strategy
- Antifungal resistance and susceptibility
- Alcohol Consumption and Health Effects
- Genetic Syndromes and Imprinting
Technical University of Munich
2008-2025
Klinikum rechts der Isar
2008-2025
München Klinik
2025
Birkbeck, University of London
2022-2024
London School of Economics and Political Science
2024
Tsinghua University
2024
German Center for Infection Research
2020
Ludwig-Maximilians-Universität München
2014
The Notch pathway is an evolutionary conserved, intercellular signaling that plays important role in cell fate specification and the embryonic development of many organs, including liver. In humans, mutations receptor ligand Jagged1 gene result defective intrahepatic bile duct (IHBD) Alagille syndrome. Developmental abnormalities IHBD mice doubly heterozygous for Notch2 propose interactions its are crucial normal development. Because different types liver involved morphogenesis,...
Pancreatic cancer is one of the most fatal malignancies lacking effective therapies. Notch signaling a key regulator cell fate specification and pancreatic development; however, role individual receptors downstream largely unknown. Here, we show that Notch2 predominantly expressed in ductal cells intraepithelial neoplasia (PanIN) lesions. Using genetically engineered mice, demonstrate effect conditional receptor ablation Kras G12D -driven carcinogenesis. Deficiency but not Notch1 stops PanIN...
Abstract Notch signaling through the Notch2 receptor is essential for normal biliary tubulogenesis during liver development. However, events downstream of critical this process are less well defined. Furthermore, whether also underlies adult hepatic cell fate decisions largely unknown. By implementing different genetic mouse models, we provide a comprehensive analysis that defines role in control developing and liver. We show cell-specific activation by Notch2IC ( N2IC ) transgene leads to...
Abstract Purpose Doxycycline post-exposure prophylaxis (Doxy-PEP) reduces the likelihood of Chlamydia and early syphilis by approximately two-thirds. Currently, data on frequency Doxy-PEP use in men who have sex with (MSM) are limited. This study aimed to assess knowledge, attitude towards, among MSM Germany. Methods We conducted a national online survey Germany from summer fall 2023, recruiting transgender women. Participants were invited complete through social media, dating platforms,...
Sexually transmitted infections (STIs) are increasing among men who have sex with (MSM). Screening can improve the detection and outcome of asymptomatic STIs in high-risk populations. Self-sampling may be a resource-optimized strategy; however, its diagnostic reliability compared to testing by healthcare professionals (HCPs) requires further investigation. In this prospective, multicenter cohort study high-income country, MSM sexual risk profile for were included. Sequential swabs STI...
A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) suicidal intention. On admission, the did not show any clinical signs intoxication laboratory findings were unremarkable. After 6 hours intensive care monitoring, referred to a psychiatric clinic. 5 days day intoxication, serum...
At the beginning of COVID-19 pandemic, when mortality was high, social distance only option to prevent transmission SARS-CoV-2 and prohibit uncontrolled spreading. As impact distancing on sexual behavior unclear, we aimed assess influence risk seroconversion in HIV pre-exposition prophylaxis (PrEP) users after declaration pandemic.Prospective study IgG-antibody rate over time men having sex with (MSM) using PrEP at a single tertiary university hospital Munich, Germany, during quarterly (Q)...
Data on ocular syphilis (OS) and its clinical presentation are currently insufficient. This study aimed to investigate the characteristics of a cohort with high OS incidence at university hospital in Germany, focusing OS.This single-center retrospectively analyzed data 90 patients 109 episodes between 2008 2018. Cases were identified additionally reevaluated through study-specific secondary assessment by an ophthalmologist specializing uveitis.Twenty-three (26%) diagnosed OS, 16 (70%) whom...
Stocks returns are moved by many risk factors. Thematic stock indices try to represent these factors, but limited the fact that factors not directly observable. This paper shows a method uncover hidden through text analysis. It applies dynamic variant of Latent Dirichlet Allocation (LDA) model annual and quarterly reports find topic distribution for each stock. is then interpreted as factor partition transformed into standard normal basis which corresponds pure The weights indicate...
Symptoms of primary HIV infection, including fever, rash, and headache, are nonspecific often described as flu-like. COVID-19 vaccination side effects, such which occur in up to 10% people following vaccination, can make the diagnosis acute infection even more challenging.A 26-year-old man presented with fever headache vaccination. The symptoms were initially thought be vaccine effects. A diagnostic workup was conducted due persisting > 72 h he diagnosed Fiebig stage II 3 weeks after having...
A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose his antiretroviral therapy (ART) comprising dolutegravir (DTG -Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) suicidal intention.On admission, the did not show any clinical signs intoxication laboratory findings were unremarkable.After 6 hours intensive care monitoring, referred to a psychiatric clinic.5 days day intoxication, serum creatinine...
Stocks' returns are moved by many risk factors. Thematic stock indices try to represent these factors but limited the fact that not directly observable. This paper shows a method uncover hidden through text analysis. It applies dynamic variant of Latent Dirichlet Allocation (LDA) model annual and quarterly reports find topic distribution for each stock. is then interpreted as factor partition transformed into standard normal basis which corresponds pure The weights indicate proportions...
Abstract BackgroundSymptoms of primary HIV infection, including fever, rash, and headache, are nonspecific often described as flu-like. COVID-19 vaccination side effects, such which occur in up to 10% people following vaccination, can make the diagnosis acute infection even more challenging.Case PresentationA 26-year-old man presented with fever headache vaccination. The symptoms were initially thought be vaccine effects. A diagnostic workup was conducted due persisting > 72 hours he...
Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in United States and, to date, without effective treatment. PDAC develops through defined preneoplastic lesions which pancreatic intraepithelial neoplasia (PanIN) are most common precursors. Acinar-to-ductal metaplasia (ADM) appears be an important prerequisite for PanIN development, especially under inflammatory conditions. The Notch signaling pathway plays a key role cell fate...