A5037319451- Education, Psychology, and Social Research
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Renal cell carcinoma treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- SARS-CoV-2 and COVID-19 Research
- Economic and Financial Impacts of Cancer
- Anesthesia and Sedative Agents
- Neuroendocrine Tumor Research Advances
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Chronic Lymphocytic Leukemia Research
- Pancreatitis Pathology and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Pain Management
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Cancer Risks and Factors
Masaryk University
2016-2025
Institute of Health Information and Statistics
2015-2025
Prokhorov General Physics Institute
2024
Zero to Three
2024
Pirogov Russian National Research Medical University
2024
Russian Academy of Sciences
2024
University Hospital Plzen
2021
University Hospital Brno
2018
University of Ostrava
2016
University Hospital Ostrava
2016
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades immunity conferred by vaccines and previous infections.We used a Cox proportional hazards model logistic regression on individual-level population-wide data from the Czech Republic to estimate risks infection hospitalization, including states.A recent (≤2 months) full vaccination reached vaccine effectiveness (VE) 43% (95% confidence interval [CI], 42%-44%) against compared 73% CI, 72%-74%) Delta. A...
To study associations of bullous pemphigoid (BP) with internal diseases, we conducted a retrospective case control assessing the frequency selected diseases - diabetes mellitus, neurological malignant tumors, benign prostate hyperplasia, hypertension and ischemic heart disease in patients BP. 89 BP, whose data were retrieved from register Centre period 1991-2006, matched controls same age gender, recruited treated for other skin diseases. The at time onset BP was evaluated by unconditional...
Background:The Czech Republic ranks among the countries with highest cancer burden in Europe as well worldwide.The purpose of this study is to summarize long-term trends and provide up-to-date estimates incidence mortality rates after 2011.Data Methods: The National Cancer Registry (CNCR) was instituted 1977 contains information collected over a 34-year period standardized registration covering 100% dia gnoses within entire population.The CNCR analysis supported by demographic data Death...
Studies demonstrating the waning of post-vaccination and post-infection immunity against covid-19 generally analyzed a limited range vaccines or subsets populations. Using Czech national health data from beginning pandemic till November 20, 2021 we estimated risks reinfection, breakthrough infection, hospitalization death by Cox regression adjusted for sex, age, vaccine type vaccination status. Vaccine effectiveness infection declined 87% at 0-2 months after second dose to 53% 7-8 BNT162b2...
The Omicron variant of the SARS-CoV-2 virus carries mutations, which enable it to evade immunity conferred by vaccines and previous infections. We used a Cox proportional hazards model logistic regression on individual-level data all laboratory-confirmed infections in Czech Republic estimate relative risk infection, hospitalization, including severe states, for Delta variants, adjusting sex, age, vaccine type vaccination status. A recent (<2 months) two-dose reached VE 43% (95% CI: 42-44)...
Background: The concurrence of obstructive sleep apnea (OSA) and chronic pulmonary disease (COPD) is generally identified as an overlap syndrome. Only limited evidence available on the prevalence OSA in patients with stable COPD, essentially no data hospitalized for COPD exacerbation. aims study were to determine ratio exacerbation identify confounders detected subjects. Methods: 101 at Department Respiratory Diseases course four months. Seventy-nine consecutive enrolled 35 these subjects...
Rocuronium for cesarean delivery under general anesthesia is an alternative to succinylcholine rapid-sequence induction of because the availability sugammadex reversal neuromuscular blockade. However, there are no large well-controlled studies in women undergoing delivery. The aim this noninferiority trial was determine whether rocuronium and confer benefit time tracheal intubation (primary outcome) other blockade outcomes compared with succinylcholine, rocuronium, neostigmine delivery.We...
Abstract Background To determine the benefit of contrast-enhanced ultrasound (CEUS) in assessment breast lesions. Methods A standardized was performed 230 lesions classified as BI-RADS category 3 to 5. All were subjected qualitative and quantitative analysis. MVI (MicroVascular Imaging) technique used derive analysis parameters; blood perfusion assessed (perfusion homogeneity, type vascularization, enhancement degree). Quantitative conducted estimate changes within drawn regions interest...
Mannose-binding lectin (MBL), activating protein of the pathway complement system, is an important component non-specific immune response. MBL2 gene polymorphisms, both in coding and promoter regions, lead to low or deficient serum MBL levels. Low levels were shown be associated with serious infectious complications, mainly patients whom other system barriers disturbed (granulocytopenia, cystic fibrosis). We have analysed two (-550 -221) three exon (codons 52, 54 57) polymorphisms a total 94...
Randomizované klinické studie jsou považovány za zlatý standard pro medicínu založenou na důkazech, avšak tyto nemusejí být vždy proveditelné nebo etické a vědci musejí spoléhat observační výzkumné databáze. Nicméně získání spolehlivých výsledků z těchto studií vyžaduje odstranění potenciálního vlivu dalších faktorů. Naštěstí existuje několik statistických metod schopných identifikovat snížit vliv Jednou nich je metoda propensity skóre, která v současné době často používána odhad...
Abstract Background and Aims The pathogenesis risk factors for early postoperative endoscopic recurrence of Crohn’s disease [CD] remain unclear. Thus, this study aimed to identify whether histological inflammation at the resection margins after an ileocaecal influences recurrence. Methods We have prospectively followed up patients with CD who underwent our hospital between January 2012 2018. specimens were histologically analysed both [ileal colonic]. evaluated results are correlated based...
Objectives The development of fundic gland polyps (FGPs) is the most common side effect long-term proton pump inhibitor (PPI) use; however, drug use characteristics and their impact on risk other gastric polyp remain unclear. We aimed to identify influence PPI administration, as well its duration dose, in polyps. Methods A prospective cohort study was conducted consecutive patients who underwent gastroscopy between September 2017 August 2019. Detailed polyps, Helicobacter pylori infection,...
S ummary Background Evidence is accumulating that the effectiveness of covid-19 vaccines against infection wanes, reaching relatively low values after 6 months. Published studies demonstrating this effect based their findings on a limited range or subset populations, and did not include booster vaccine doses immunity obtained due to infection. Here we evaluate vaccines, previous infection, hospital admission death for whole population in Czech Republic. Methods Data used study cover Republic...
The aim of the present retrospective study was to analyze clinical outcome and risk factors associated with treatment outcomes according KRAS status in patient metastatic colorectal cancer (mCRC) treated bevacizumab (bev) plus chemotherapy first-line setting. We performed observational on 1622 patients mCRC bev oxaliplatin- or irinotecan-based chemotherapy, correlated mutation status. primary endpoint progression-free survival (PFS) additionally overall (OS). Adverse events including...
The aim of the nationwide prospective seroconversion (PROSECO) study was to investigate dynamics anti-SARS-CoV-2 IgG antibodies in Czech population. Here we report on baseline prevalence from that study.The included first 30,054 persons who provided a blood sample between October 2020 and March 2021. Seroprevalence compared calendar periods, previous RT-PCR results other factors.The data show large increase seropositivity over time, 28% October/November 43% December 2020/January 2021 51%...
Objectives . To extend and revise the diagnostic value of contrast‐enhanced ultrasonography (CEUS) for differentiation between malignant benign thyroid nodules. Methods This single‐institution prospective study aims to compare CEUS qualitative objective quantitative parameters in Consecutive cohort 100 patients was examined by CEUS, 68 out them were further analysed detail. All included underwent cytological and/or histopathological verification diagnosis. Results Fifty‐five (81%) nodules...