A5080643346- Endometrial and Cervical Cancer Treatments
- Breast Cancer Treatment Studies
- Uterine Myomas and Treatments
- Breast Implant and Reconstruction
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Endometriosis Research and Treatment
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Minimally Invasive Surgical Techniques
- Lymphatic System and Diseases
- Health, Medicine and Society
- Cardiac and Coronary Surgery Techniques
- Cholinesterase and Neurodegenerative Diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Coronary Interventions and Diagnostics
- Healthcare Systems and Practices
- Appendicitis Diagnosis and Management
- Sarcoma Diagnosis and Treatment
- Gynecological conditions and treatments
- Colorectal and Anal Carcinomas
Breast Center
2021-2024
University Hospital of Lausanne
2018-2024
University of Lausanne
2021-2024
Centre Hospitalier Universitaire de Toulouse
2017-2021
Hôpital de Sion
2017-2018
Hôpital du Valais
2017
Centre National de la Recherche Scientifique
2015
Université Paris Cité
2015
Hôpital Necker-Enfants Malades
2014
Hôpital Purpan
2011
Abstract Expansion of antigen-experienced CD8 + T cells is critical for the success tumour-infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer 1 . Interleukin-2 (IL-2) acts as a key regulator cytotoxic functions by promoting expansion and capability 2,3 Therefore, it essential to comprehend mechanistic barriers IL-2 sensing tumour microenvironment implement strategies reinvigorate responsiveness antitumour responses. Here we report that prostaglandin E2 (PGE 2...
We developed tailored axillary surgery (TAS) to reduce the tumor volume in patients with clinically node-positive breast cancer point where radiotherapy can control it. The aim of this study was quantify extent load reduction achieved by TAS.
Importance The role of axillary lymph node dissection (ALND) to determine nodal burden inform systemic therapy recommendations in patients with clinically (cN)–positive breast cancer (BC) is currently unknown. Objective To address the association ALND cN-positive BC upfront surgery setting and after neoadjuvant chemotherapy (NACT). Design, Setting, Participants This was a prospective, observational, cohort study conducted from August 2018 June 2022. preplanned within phase 3 randomized...
Objectives To assess the morbidity from closed laparoscopic access and define role of previous surgery on occurrence these complications. Design Methods We prospectively recorded data all procedures between January 2000 2001. compared results patients without abdominal (group I) with prior II). The insertion site for Verres needle was trans‐umbilical in group I left upper quadrant II. Setting Gynaecology department a University Hospital. Population All Main outcome measures Results Four...
TPS611 Background: Axillary lymph node dissection (ALND) is standard of care for most patients with clinically node-positive breast cancer (cN+BC), either in the adjuvant setting or case residual nodal disease after neoadjuvant chemotherapy (NACT). At least one quarter experience long term morbidity ALND. The TAXIS trial was designed to investigate if axillary radiotherapy (ART) can replace ALND cN+ BC who underwent tailored surgery (TAS), which recognized as important uncertainties and...
The aim of this study was to evaluate clinical practice heterogeneity in use neoadjuvant systemic therapy (NST) for patients with clinically node-positive breast cancer Europe.The preplanned the international multicenter phase-III OPBC-03/TAXIS trial (ClinicalTrials.gov Identifier: NCT03513614) include first 500 randomized confirmed nodal disease at time surgery. TAXIS study's pragmatic design allowed both and adjuvant setting according preferences local investigators who were encouraged...
Background. Vaginal hysterectomy (VH) is being performed increasingly by gynecologic surgeons. Thus, enlarged uteri are more frequently removed vaginally, requiring reducing techniques to allow vaginal extraction. Material and methods. We designed a randomized prospective study compare bisection–morcellation myometrial coring. Patients scheduled for VH or laparoscopically assisted (LAVH) were offered entry into the study. Endometrial cancer was an exclusion criterion. Uterine size not...
<i>Objective:</i> To assess the feasibility, tolerance and diagnostic accuracy of endometrial biopsy (EB) during sonohysterography (SH) compared to EB after hysteroscopy (HSC) in disorders. <i>Methods:</i> 105 consecutive patients with irregular uterine bleeding were included prospectively calendar year 2001. SH flexible HSC performed an office setting, subsequently a random order, by two different practitioners blind former experiment. SH-EB was using 3.1-mm...
To assess the effect of laparoscopy on circulating tumor cell (CTC) detection in case carcinosis.We compared versus laparotomy blood release an animal model ovarian carcinosis obtained by intraperitoneal inoculation IGR-OV1 cells nude rats. Animals were randomly assigned to one following groups: CO(2) (L), gasless (GL), midline (ML), or general anesthesia as control (C). A 0.5 ml sample was taken each before and after experiment tested with a novel assay, ISET (isolation size epithelial...
In gynecological surgery to date, two distinct types of endoscopic accesses have been used perform para-aortic lymphadenectomies: transperitoneal and extraperitoneal, each with advantages disadvantages.1 We propose develop a new mini-invasive access an extraperitoneal lymphadenectomy via single-port umbilical device that, our knowledge, has never described. This innovative approach combines both intraperitoneal procedure the same incision using one single trocar. A 3–4 cm trans-umbilical is...