A5105927227- Antifungal resistance and susceptibility
- Plant Pathogens and Fungal Diseases
- Microbial infections and disease research
- Bacterial biofilms and quorum sensing
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Use and Resistance
- Complementary and Alternative Medicine Studies
- Cystic Fibrosis Research Advances
- Fungal Infections and Studies
- Infections and bacterial resistance
- Fungal Biology and Applications
- Mycotoxins in Agriculture and Food
- Fungal and yeast genetics research
- Gastrointestinal disorders and treatments
- Oral and gingival health research
- Pharmaceutical Practices and Patient Outcomes
- Antibiotic Resistance in Bacteria
- Plant-Microbe Interactions and Immunity
- Intracranial Aneurysms: Treatment and Complications
- Intestinal and Peritoneal Adhesions
- Infectious Diseases and Mycology
- Metabolomics and Mass Spectrometry Studies
- Psoriasis: Treatment and Pathogenesis
- Diet, Metabolism, and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Thomas Jefferson University Hospital
2024-2025
Neurological Surgery
2024-2025
Beirut Arab University
2018-2025
Thomas Jefferson University
2024-2025
Mayo Clinic
2024
WinnMed
2024
Centre Hospitalier Universitaire d'Angers
2022
Université d'Angers
2014-2022
Massachusetts Institute of Technology
2019
Université Bretagne Loire
2018
Background Scedosporium species are filamentous fungi causing a wide spectrum of infections in healthy and debilitated individuals. Despite their clinical significance, the ecology remains understudied, particularly Middle East. Methods In this context, we conducted an environmental study to elucidate distribution ecological preferences North Lebanon. One hundred fifty-five soil samples were collected from different areas analyzed for several chemical parameters. isolates then selected...
BACKGROUND AND OBJECTIVES: Mechanical thrombectomy (MT) is the standard of care in patients with large vessel occlusion (LVO). Despite successful recanalization, about 5% are at risk for developing recurrent LVO. Our study identifies predictors LVO and outcomes after repeat MT. METHODS: This was a retrospective multicenter who underwent MT Cases were developed recanalization (thrombolysis cerebral infarction ≥2b) controls did not develop Descriptive statistics univariate analyses used to...
Scedosporium boydii is an opportunistic filamentous fungus which may be responsible for a wide variety of infections in immunocompetent and immunocompromised individuals. This belongs to the apiospermum species complex, usually ranks second among fungi colonizing airways patients with cystic fibrosis (CF) lead allergic bronchopulmonary mycoses, sensitization, or respiratory infections. Upon microbial infection, host phagocytic cells release reactive oxygen (ROS), such as hydrogen peroxide,...
Helicobacter pylori (H. pylori) infection occurs among half of the general population worldwide, with high geographic variability. Even though H. is leading cause several gastric diseases, ranging from gastritis and peptic ulcers to malignancies, such as cancer mucosa-associated lymphoid tissue lymphoma, most infections remain asymptomatic. Early detection eradication can definitely prevent severe long-term diseases associated pylori. In Lebanon, prevalence not well documented, especially in...
<abstract><sec> <title>Background</title> <p>Extended-spectrum beta-lactamase (ESBL)-producing <italic>Enterobacteriaceae</italic> including <italic>Escherichia coli</italic> (<italic>E. coli</italic>), are recognized as a global public health threat due to their multidrug-resistant (MDR) phenotypes and rapid dissemination in aquatic environments. Nevertheless, studies investigating the prevalence antimicrobial resistance...
Urbanization has caused severe negative impacts on intra-urban river water worldwide. In this study, the WHO drinking standards (2024) were used as reference to assess physicochemical properties, heavy metals (HMs) content and microbial load in sediment samples collected from 25 locations along Rachiine River, located Northern Lebanon, during wet dry periods. Multivariate statistical analysis was applied evaluate seasonal variations quality, determine pollution sources. The assessment...
Early assessment of adverse drug effects in humans is critical to avoid long-lasting harm. However, current approaches for early detection still lack predictive and organ-specific biomarkers evaluate undesired responses humans. Microphysiological systems (MPSs) are vitro representations human tissues provide translational insights physiological processes. In this study, a brain MPS was utilized assess molecular signatures neurotoxic non-neurotoxic compounds using targeted untargeted...
The slowing-down de novo drug-discovery emphasized the importance of repurposing old drugs. This is particularly true when combating infections caused by therapy-refractory microorganisms, such as Scedosporium species and Lomentospora prolificans. Recent studies on responses to oxidative stress underscored targeting underlying mechanisms. Auranofin, ebselen, PX-12, honokiol, a lesser extent, conoidin A are known disturb redox-homeostasis systems in many organisms. Their antifungal activity...
<ns4:p>Background <ns4:italic>Helicobacter pylori</ns4:italic> and intestinal parasites are well-known for their high prevalence in children, especially developing countries. However, concomitant infections poorly documented. In this study, we aimed to evaluate the association between <ns4:italic>H. among hospitalized children adolescents with upper gastrointestinal complaints Northern Lebanon. Methods A cross-sectional study was conducted involving 297 pediatric patients, aged 1 15 years,...
Scedosporium species are opportunistic filamentous fungi found in human-impacted areas. Clinically relevant species, such as S. apiospermum, rank the second most frequent colonizers of airways patients with cystic fibrosis (CF), which characterized by persistent oxidative stress. This raises question how abate conditions imposed hostile environments. Since High Osmolarity Glycerol (HOG) pathway plays a central role fungal adaptation to stress, we aimed pheno-profile involvement response...
Aim of the study Since beginning COVID-19 pandemic, empirical antibiotics prescription has increased globally in patients with for suspected or confirmed bacterial infection. Hence, concerns have been raised about potential rise antibiotic resistance that will create further challenges antimicrobial stewardship. This descriptive cross-sectional was conducted to assess healthcare workers attitudes and practices regarding during pandemic Lebanon. Methods used conduct The survey distributed...
Helicobacter pylori and intestinal parasites are well-known for their high prevalence in children, especially developing countries. However, concomitant infections poorly documented. In this study, we aimed to evaluate the association between H. among hospitalized children adolescents with upper gastrointestinal complaints Northern Lebanon. A cross-sectional study was conducted involving 297 pediatric patients, aged 1 15 years, who presented symptoms. The socio-demographic, lifestyle,...