A5045209802- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Congenital Anomalies and Fetal Surgery
- Liver Disease Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Appendicitis Diagnosis and Management
- Pancreatitis Pathology and Treatment
- Abdominal Trauma and Injuries
- Clinical Nutrition and Gastroenterology
- Gastrointestinal disorders and treatments
- Immune Response and Inflammation
- Neuroendocrine Tumor Research Advances
- Urological Disorders and Treatments
- Esophageal and GI Pathology
- Infant Nutrition and Health
- Amoebic Infections and Treatments
- Seedling growth and survival studies
- Forest Management and Policy
- History of Medical Practice
Mater Hospital
2001-2021
University of Southampton
2020
University of Ulster
2016
Belfast City Hospital
2016
Belfast Health and Social Care Trust
2013
Queen's University Belfast
1990-2013
Mater Health Services
1999-2012
Louisiana State University
2003-2006
Mater Misericordiae University Hospital
1997
Hôpital Paul-Brousse
1992-1993
Objective Currently, there is considerable controversy about the place of transplantation in treatment hepatocellular carcinoma (HCC). This study compared resection to cirrhotic patients with HCC order determine reasonable indications each treatment. Summary Background Data The usual procedure resect when feasible and transplant other cases. Methods Three-year survival without recurrence was analyzed 60 who underwent transplantation. Several prognostic factors, such as size, number nodules,...
Between 1960 and 1990, resection was performed in 23 of 122 patients who underwent surgical treatment for hilar cholangio-carcinoma. Local excision the lesion alone 10 cases (43%). Hepatic tumor extending to secondary bile ducts or hepatic parenchyma 13 (57%): extended right hepatectomy (3), (1), left (6), (2), lobectectomy (1). In three other cases, by total liver transplantation performed, but these were not included analysis results resection. Significant operative complications occurred...
BackgroundThe interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction progression-free survival allocated to cetuximab plus chemotherapy compared those given alone. The focus present was assess effect on overall survival.MethodsNew multicentre, open-label, randomised, controlled, phase 3 trial. Adult (aged ≥18 years) KRAS wild-type (codons 12, 13, and 61) or suboptimally metastases WHO performance status 0–2...
Abstract Intestinal mucosal barrier function in obstructive jaundice was assessed an animal model and patients. The effect of internal biliary drainage patients also examined. Bile duct ligation for 1 week the rat resulted significant bacterial translocation (in seven 12 animals following versus none sham-operated controls, P<0·01). permeability, measured by urinary recovery orally administered polyethylene glycol, significantly increased (+ 66·2 per cent −11·6 sham, A prospective...
This study aimed to determine the effect of LP229v on intestinal permeability and tumour necrosis factor (TNF) p55 receptor concentrations in patients with obstructive jaundice undergoing biliary drainage.Patients drainage were recruited randomized into three groups receive Lactobacillus plantarum 299v (LP299v), inactivated LP299v (placebo) or water. These administered daily at noon until 7 days after drainage. Intestinal was measured using lactulose/mannitol (L/M) dual sugar absorption test...
Systemic endotoxaemia is implicated in the development of complications associated with obstructive jaundice. The aims these studies were to assess systemic immune response intervention patients jaundice and compare effects surgical non-surgical biliary drainage on host function gut barrier function.In first study, 18 jaundiced 12 control studied responses before after intervention. In second assessed following non-operative decompression 45 jaundice.Endotoxin antibody concentrations fell...
Citations of articles published from 1990 to 2002 faculty teaching at selected southern universities are counted and analyzed form a core list the most highly cited journals for field forestry. Core lists developed assistant, associate, full professors; citation differences among three groups analyzed. The is compared with primary forestry serials compiled by Cornell Agricultural Literature Project. analysis focuses on similarities both studies, discusses importance ecological...
Extrahepatic biliary obstruction is associated with the failure of intestinal barrier function, allowing bacteria and other substances from intestine to enter circulation initiate a systemic inflammatory response, causing impairment organ function. Probiotic have been shown beneficial effects on function in conditions, but their never studied obstruction.This study examined enteral administration Lactobacillus plantarum species 299 (LP299) oatmeal fibre compared sterile water or alone an...
Introduction An exaggerated proinflammatory response to endotoxaemia can occur in obstructive jaundice. The aims of this study were determine the hepatic and anti-inflammatory cytokine experimental biliary obstruction source interleukin-6 (IL-6) using immunohistochemistry. Methodology Male Wistar rats randomized into three groups: bile duct ligation (BDL), sham operation, control groups. They weighed before surgery after 1 week. On day 8, perfusion was performed with endotoxin (Escherichia...
A transcription regulatory complex (TRC) that includes Ets1, Ets2, PEA3 and β-catenin/T-cell factors regulates osteopontin (OPN) is implicated in colorectal cancer (CRC) dissemination. The consistency of OPN transcriptional control between primary CRC metastases unclear. This study investigates expression prognostic significance the OPN–TRC human associated liver (CRLM). Osteopontin–TRC were assayed by digital microscopy 38 CRCs matched CRLM specimens assessed against clinical prognosis. In...
<i>Objective:</i> To determine the effects of enteral administration glutamine on intestinal barrier function in experimental biliary obstruction. <i>Background:</i> Extrahepatic obstruction is associated with failure function, allowing bacteria and other substances from intestine to enter circulation initiate a systemic inflammatory response, causing impairment multiple organs. The amino acid has been shown improve conditions, but its have not fully examined....
Fusobacterium nucleatum is a periodontal commensal and pathogen. In rare cases, these anaerobic gram-negative bacilli have been reported to cause pyogenic liver abscesses (PLAs). We describe patient who developed abscess during the COVID-19 pandemic was unable access restricted General Dental Services at this time. She subsequently F. bacteraemia abscess. The non-specific signs symptoms experienced meant self-isolated due suspected infection presentation hospital delayed. also include...
Two novel antiendotoxin peptides, P6 and C1, may reduce the inflammatory response. This study aimed to determine effect of endotoxin on hepatic cytokine response assess C1-related attenuation proinflammatory endotoxemia, in experimental biliary obstruction.15 Male Wistar rats were randomized one three groups: bile duct ligation (BDL)+P6 (n=5), BDL+C1 BDL+no peptide (n=5). Rats weighed underwent BDL surgery day 1. On 8, reweighed isolated perfusion was carried out. or C1 (10 μmol/l)...