A5045782833- Inflammatory Bowel Disease
- Microscopic Colitis
- Vitamin D Research Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Reproductive System and Pregnancy
- Gastroesophageal reflux and treatments
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Anorectal Disease Treatments and Outcomes
- Liver Disease Diagnosis and Treatment
- Complement system in diseases
- Digestive system and related health
- HIV Research and Treatment
- Infant Nutrition and Health
- Pelvic floor disorders treatments
- Systemic Lupus Erythematosus Research
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders Research
- HIV/AIDS Research and Interventions
Aarhus University Hospital
2014-2023
New York University Press
2021
Cambridge University Press
2021
Nanjing Medical University
2020
Jiangsu Province Hospital
2020
Creative Research Enterprises (United States)
2020
Aarhus University
2001-2017
GTx (United States)
2004
Danish National Research Foundation
2004
Aalborg University Hospital
1986-1990
Vitamin D has immune-regulatory functions in experimental colitis, and low vitamin levels are present Crohn's disease.To assess the effectiveness of D3 treatment disease with regard to improved course.We performed a randomized double-blind placebo-controlled trial benefits oral disease. We included 108 patients remission, which fourteen were excluded later. Patients receive either 1200 IU (n = 46) or placebo 48) once daily during 12 months. The primary endpoint was clinical relapse.Oral...
Via cytoplasmic signal transduction pathways, cytokines induce a variety of biological responses and modulate the outcome inflammatory diseases malignancies. Crohn's disease is chronic bowel unknown etiology. Perturbation intestinal cytokine homeostasis believed to play pivotal role, but pathogenesis not fully understood. Here, we study T cells from healthy volunteers. We show that STAT3 STAT4 are constitutively activated in patients The activation specific, because other STAT proteins...
Background and aims: Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure murine models of intestinal inflammation have demonstrated beneficial effects 1,25-(OH)2 treatment, we hypothesised that activity is associated low levels.
Recently, the intestinal microbiota has been emphasised as an important contributor to development of metabolic syndrome. Dietary fibre may exert beneficial effects through modulation and end products. We investigated a diet enriched with two different dietary fibres, arabinoxylan resistant starch type 2, on gut microbiome faecal short-chain fatty acids. Nineteen adults syndrome completed this randomised crossover study 4-week interventions low-fibre Western-style diet. Faecal samples were...
Treatment with latency reversing agents (LRAs) enhances human immunodeficiency virus type 1 (HIV-1) transcription in vivo but leads to only modest reductions the size of reservoir, possibly due insufficient immune-mediated elimination infected cells. We hypothesized that a single drug molecule—a novel Toll-like receptor 9 (TLR9) agonist, MGN1703—could function as an enhancer innate immunity and LRA vivo. conducted single-arm, open-label study which 15 virologically suppressed HIV-1–infected...
Abstract Background Motorized spiral enteroscopy (MSE) has been shown to be safe and effective for deep in studies performed at expert centers with limited numbers of patients without previous abdominal surgery. This study aimed investigate the safety, efficacy, learning curve associated MSE a real-life scenario, inclusion after surgery altered anatomy. Methods Patients indications were enrolled prospective observational multicenter study. The primary objective was serious adverse event...
OBJECTIVES: Inflammatory activation of resident hepatic macrophages (Kupffer cells) by portal-derived lipopolysaccharide (LPS) has a primary role in animal models alcoholic liver disease, but it not been systematically or longitudinally studied human hepatitis (AH). METHODS: We followed 50 patients with AH for 30 days. 26 stable cirrhosis and 20 healthy individuals were controls. measured the plasma (P) concentrations soluble CD163 (sCD163; specific marker inflammatory macrophage activation)...
BackgroundWhether infliximab therapy can be successfully discontinued after patients with Crohn’s disease have attained sustained, clinical, biochemical, and endoscopic remission is unknown.MethodsWe conducted a multicenter, randomized, double-blind, placebo-controlled withdrawal study of in who were standard maintenance for at least 1 year. Patients randomly assigned 1:1 to continue or receive matching placebo 48 weeks. The primary end point was time relapse.ResultsThis 115 either the...
Th17 cells, a subset of CD4+ T cells that produce interleukin (IL)-17A, IL-17F, IL-21, IL-22, IL-26, and the chemokine CCL20 are critically involved in mucosal inflammation observed Crohn's disease (CD). However, their role as mediators CD has been questioned by recent clinical trial which anti-IL-17A (secukinumab) treatment was ineffective. Besides being pro-inflammatory, Th17-related cytokines mediate protective functions. We aimed to investigate inflammation.Blood samples from 26 patients...
Gastrointestinal (GI) dysmotility may present secondary to inflammatory bowel disease. The main aim of this study was investigate GI motility in ulcerative colitis (UC) patients during severe disease activity.Twenty with UC were studied a novel telemetric capsule system (3D-Transit) designed for minimally invasive, ambulatory assessment total and regional transit times. Ten available follow-up remission. Data compared those 20 healthy subjects (HS).Total time significantly longer (median...
Summary CD4+CD25+ regulatory T cells (Tregs) are involved in the maintenance of peripheral tolerance and ensure a balanced immune response competent fighting pathogens at same time recognizing commensals as harmless. This feature is lost Crohn's disease (CD). The forkhead/winged helix transcription factor FoxP3 master gene for Treg function defects lead to clinical picture similar inflammatory bowel (IBD). Murine colitis can be cured by adoptive transfer Tregs ex vivo-generated gut-specific...
Abstract In Crohn's disease (CD) mucosal T‐cells produce increased interferon‐ γ (IFN‐ ) and tumour necrosis factor‐ α (TNF‐ levels TNF‐ antibody treatment [Infliximab (Ifx)] is effective. Osteopontin (OPN), a glycoprotein stimulating activated T‐lymphocytes, may be involved in the disturbed immune‐regulation but also normal immune‐homeostasis repair, since it expressed many tissues present human milk. This study investigates plasma‐OPN CD patients during Ifx vitro effect of OPN on...
Summary Background Excessive amounts of bile acids entering the colon due to acid malabsorption cause chronic diarrhoea. Diagnosis is possible by measuring retention fraction orally ingested 75 Selenium homotaurocholic (Se HCAT ). The knowledge long‐term effects medical treatment sparse. Aim To describe diarrhoea, adherence treatment, and quality life in a large, well‐defined cohort patients with Methods A retrospective survey was performed among 594 verified Se scans at our unit between...
Aliment Pharmacol Ther 2010; 32: 1364–1372 Summary Background Vitamin D3 has shown immune‐modulating effects in CD4+ T cells from Crohn’s disease patients vitro . Aim To investigate the of vivo vitamin treatment on patients. Methods Peripheral blood mononuclear (PBMC) were isolated at week 0 and 26 10 D3‐ placebo‐treated participating a randomized, placebo‐controlled, clinical trial study. Monocyte‐depleted PBMC stimulated with anti‐CD3 anti‐CD28, cultured for 7, days, to T‐cell...
Toll-like receptor 9 (TLR9) agonists are being developed for treatment of colorectal and other cancers, yet the impact these drugs on human intestines remains unknown. This, together with fact that there additional potential indications TLR9 agonist therapy (e.g., autoimmune infectious diseases), led us to investigate MGN1703 (Lefitolimod) intestinal homeostasis viral persistence in HIV-positive individuals. Colonic sigmoid biopsies were collected (baseline week four) from 11 HIV+...